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IHHS Health & Wellness Center
1607 South H Street, Bakersfield, CA 93304 Hormonal, Homeopathic, & Nutritional Services Office (661)-837-0453 FAX (661)-837-0560 PROGESTERONE USE IN MEN

Positive Progesterone Effects,
reduced stress and anxiety
enhanced cognitive function
facilitates thyroid hormone action
normalizes blood sugar levels
natural diuretic
normalizes blood sugar levels
normalizes zinc and copper levels
restores proper cell oxygenation levels
normalizes blood clotting
reduced anxiety
nerve growth
see information below towards the end for an even more information on actions of progesterone in men.
Negative Progesterone Effects are rare. Initially there may be lethargy and fatigue, but this passes as
one adapts to therapy. In the long run there may be abdominal weight gain or loss, depending on the
person.
Why progesterone for men?
Progesterone is commonly thought of as a 'female' sex hormone. This is misleading as it is vital to sustain
not just health but life itself in all mammals of both sexes.
As a man gets older testosterone is converted into di-hydrotestosterone (DHT), which some believe is the
cause of benign prostatic hyperplasia (BPH) and cancer, but some do not.
Oestrogen levels also increase as a man gets older. Oestrogen is known to stimulate cell growth.
Reading between the lines, because as yet, there is no definitive study done on this, it appears to be the
increased oestrogen level which is the problem and not the two testosterones. As progesterone is a
powerful counter-balance for estrogen, progesterone for men is essential.
If in fact testosterone were the culprit, then men aged 22 would have the highest incidence of BPH and
cancer, as testosterone levels are at their highest point in the early 20's, but of course they don't. From
the early twenty's to the late twenty's testosterone makes it's greatest drop, thereafter it continues to
decline, but at a slower rate.
BPH starts affecting a man in his fifties and interestingly oestradiol levels start climbing from the age of
fifty and are at their highest point in men in their late 60's, but during the same period progesterone levels
are declining. Progesterone for men becomes that much more important with age.
5-alpha reductase inhibitors such as finasteride are usually given to prevent the conversion of
testosterone to DHT, but research has found that progesterone is a natural inhibitor of 5-alpha reductase.
Progesterone also down regulates the action of oestrogen if used in a sufficiently high dose. The
endogenous oestrogen made by humans is now being supplemented by synthetic oestrogens found in
the environment. They are now found in food, air, water, plastics, skin care products, no one can avoid
them. Some authorities speculate this is the cause of the increase in problems such as hyperplasia or
cancers of any hormonally sensitive tissues, such as the prostate, endometrium, cervix and breasts. So,
despite often being, erroneously, thought of as a 'female' hormone progesterone for men is essential to
preserve masculinity!
It's safety for men is without question. It's now given via IV transfusions for over
70% of TBI victims are men.
Natural Treatment of excess estrogen man boobs. The safest route is to suppress oestrogen is with
progesterone.
IHHS Health & Wellness Center
1607 South H Street, Bakersfield, CA 93304 Hormonal, Homeopathic, & Nutritional Services Office (661)-837-0453 FAX (661)-837-0560 Progesterone is not a sex hormone, it plays no part in the secondary sexual characteristics which develop
at puberty. It is secreted primarily by the testes in men and the ovaries in females. Smaller amounts are
produced by the adrenal glands, the brain and glial cells.
There are no great quantitative differences between men and women (at least outside the woman's luteal
phase).
Progesterone is the precursor to the sex hormones oestrogen and testosterone, and to cortisol and
aldosterone.
Progesterone has several other advantages:
• unlike oestrogen which can exacerbate brain injury, especially in animal models of ischaemic stroke, progesterone can be given to both males and females without affecting gender and sexual functions • it's use iyielded extremely promising results and found no adverse • inhibits the mitogenic action of oestrogen • protects against breast cancer which is increasing in men • helps correct the hormonal imbalance commonly found in men with erectile dysfunction as it increases the production of nitric oxide. In much the same way as Viagra does, but with no adverse side affects • as an anti-inflammatory agent, progesterone has been shown to reduce the response of natural killer cells as well as other known initiators of inflammation. Hence it's benefit for mastalgia (breast pain/inflammation) • influences spermiogenesis, sperm capacitation/acrosome reaction and testosterone biosynthesis • is used in the treatment of benign prostate hyperplasia (BPH) in men via a transscrotal delivery • is used to lower dihydrotestosterone levels in men. The progesterone metabolite 17-0H- progesterone was found to have the highest inhibitory effect on the enzyme 5-alpha reductase which converts testosterone into DHT • is rapidly absorbed transdermally and its patterns of distribution and metabolism are comparable to those previously reported for intravascularly administered progesterone • the progesterone metabolite allopregnanolone reduces the brain's response to stress • progesterone regulates the secretion of catecholamines during stress • prevents lipid peroxidation • acutely inhibits cholesteryl ester formation which is associated with atherosclerosis • confers coronary vascular protection • improves sleep • promotes regeneration and myelination of axons • enhances remyelination in degenerative disorders • has a neuroprotective and antioxidant effect in an injured nervous system • has multiple effects on glial cells, it influences growth, differentiation and increases the expression of myelin-specific proteins in oligodendrocytes, and potentiates the formation of new myelin sheaths by Schwann cells in vivo • it reduces programmed cell death and the synthesis of inflammatory factors that can kill neurons hours to days after traumatic brain injury • systemic injections of the neurosteroid progesterone given after traumatic brain injury (TBI) have been shown to improve cognitive, sensory and motor recovery, enhancing both short and long term recovery IHHS Health & Wellness Center
1607 South H Street, Bakersfield, CA 93304 Hormonal, Homeopathic, & Nutritional Services Office (661)-837-0453 FAX (661)-837-0560 • readily crosses the blood brain barrier (BBB) reducing oedema to barely measurable levels in TBI • reduces lipid peroxidation and the generation of isoprostanes, which contribute to post-injury • produces metabolites which decrease pro-apoptotic and increases anti-apoptotic enzymes (in • reduces the expression of pro-inflammatory genes and their protein products (in TBI) • reduces the area of necrotic cell death and improves behavioural outcomes (in TBI) • protects neurons distal to the site of injury which would normally die after TBI • produces significant sparing of cognitive, sensory and spatial learning performance after bilateral It is rapidly absorbed transdermally and its patterns of distribution and metabolism are comparable to those previously reported for intravascularly administered progesterone. For this reason alone it is preferable to the other routes. Another advantage is that it can be applied anywhere. Although progesterone is circulated rapidly throughout the body, applying it to the afflicted part brings quicker relief. Steroidogenesis Pathways
Pregnenolone17Alpha-hydoxypregnenoloneDehydroepiandrosterone-Androstenediol Progesterone---->17Alpha-hydroxyprogesterone->Androstenedione===Testosterone Aldosterone (Note: Dehydroepiandrosterone (DHEA) is an alternative pathway to androstenedione and the gonadal hormones.)

Source: http://yourhomeopath.org/documents/services/Progesterone_in_Men.pdf