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Table of contents
Section I. Basic Principles 1. Introduction, Bertram G. Katzung 2. Drug Receptors & Pharmacodynamics, Mark von Zastrow and Henry R. Bourne 3. Pharmacokinetics & Pharmacodynamics: Rational Dosing & the Time Course of Drug Action, Nicholas H.G. Holford 4. Drug Biotransformation, Maria Almira Correia 5. Development and Regulation of Drugs, Barry A. Berkowitz Section II. Autonomic Drugs 6. Introduction to Autonomic Pharmacology, Bertram G. Katzung 7. Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs, Achilles J. Pappano 8. Cholinoceptor-Blocking Drugs, Achilles J. Pappano 9. Adrenoceptor Agonists & Sympathomimetic Drugs, Italo Biaggioni and David Robertson 10. Adrenoceptor Antagonist Drugs, David Robertson and Italo Biaggioni Section III. Cardiovascular-Renal Drugs 11. Antihypertensive Agents, Neal L. Benowitz 12. Vasodilators & the Treatment of Angina Pectoris, Bertram G. Katzung and Kanu Chatterjee 13. Drugs Used in Heart Failure, Bertram Katzung and William W. Parmley 14. Agents Used in Cardiac Arrhythmias, Joseph R. Hume and Augustus O. Grant 15. Diuretic Agents, Harlan E. Ives Section IV. Drugs With Important Actions on Smooth Muscle 16. Histamine, Serotonin, & the Ergot Alkaloids, Bertram G. Katzung 17. Vasoactive Peptides, Ian A. Reid 18. The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, & Related Compounds, Emer M. Smyth and Garret A. FitzGerald 19. Nitric Oxide, Samie R. Jaffrey 20. Drugs Used in Asthma, Homer A. Boushey Section V. Drugs That Act In The Central Nervous System 21. Introduction to the Pharmacology of CNS Drugs, Roger A. Nicoll 22. Sedative-Hypnotic Drugs, Anthony J. Trevor and Walter L. Way 23. The Alcohols, Susan B. Masters 24. Antiseizure Drugs, Roger J. Porter and Brian S. Meldrum 25. General Anesthetics, Paul F. White and Anthony J. Trevor 26. Local Anesthetics, Bertram G. Katzung and Paul F. White 27. Skeletal Muscle Relaxants, Paul F. White and Bertram G. Katzung 28. Pharmacologic Management of Parkinsonism & Other Movement Disorders, Michael J. Aminoff 29. Antipsychotic Agents & Lithium, Herbert Meltzer 30. Antidepressant Agents, Charles DeBattista 31. Opioid Analgesics & Antagonists, Mark A. Schumacher, Allan I. Basbaum, and Walter L. Way 32. Drugs of Abuse, Christian Luscher Section VI. Drugs Used to Treat Diseases of the Blood, Inflammation, & Gout 33. Agents Used in Anemias; Hematopoietic Growth Factors, Susan B. Masters 34. Drugs Used in Disorders of Coagulation, James L. Zehnder 35. Agents Used in Dyslipidemia, Mary J. Malloy and John P. Kane 36. Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, and Drugs Used in Gout, Daniel E. Furst, Robert W. Ulrich, and Cissy Varkey-Altamirano Section VII. Endocrine Drugs 37. Hypothalamic & Pituitary Hormones, Susan B. Masters 38. Thyroid & Antithyroid Drugs, Betty J. Dong and Francis S. Greenspan 39. Adrenocorticosteroids & Adrenocortical Antagonists, George P. Chrousos 40. The Gonadal Hormones & Inhibitors, George P. Chrousos 41. Pancreatic Hormones & Antidiabetic Druigs, Martha S. Nolte 42. Agents That Affect Bone Mineral Homeostasis, Daniel D. Bikle Section VIII. Chemotherapeutic Drugs 43. Beta-Lactam & Other Cell Wall- & Membrane Active Antibiotics, Henry F. Chambers and Daniel H. Deck 44. Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, & Oxazolidinones, Henry F. Chambers and Daniel H. Deck 45. Aminoglycosides & Spectinomycin, Henry F. Chambers and Daniel H. Deck 46. Sulfonamides, Trimethoprim, & Quinolones, Henry F. Chambers and Daniel H. Deck 47. Antimycobacterial Drugs, Henry F. Chambers and Daniel H. Deck 48. Antifungal Agents, Don Sheppard and Harry W. Lampiris 49. Antiviral Agents, Sharon Safrin 50. Miscellaneous Antimicrobial Agents; Disinfectants, Antiseptics, & Sterilants, Henry F. Chambers and Daniel H. Deck 51. Clinical Use of Antimicrobial Agents, Harry W. Lampiris and Daniel S. Maddix 52. Antiprotozoal Drugs, Philip J. Rosenthal 53. Clinical Pharmacology of the Antihelminthic Drugs, Philip J. Rosenthal 54. Cancer Chemotherapy, Edward Chu and Alan C. Sartorelli 55. Immunopharmacology, Douglas F. Lake, Adrienne D. Briggs, and Emmanuel T. Akporiaye Section IX. Toxicology 56. Introduction to Toxicology: Occupational & Environmental, Daniel T. Teitelbaum 57. Heavy Metal Intoxication & Chelators, Michael J. Kosnett 58. Management of the Poisoned Patient, Kent R. Olson Section X. Special Topics 59. Special Aspects of Perinatal & Pediatric Pharmacology, Gideon Koren 60. Special Aspects of Geriatric Pharmacology, Bertram G. Katzung 61. Dermatologic Pharmacology, Dirk B. Robertson and Howard I. Maibach 62. Drugs Used in the Treatment of Gastrointestinal Diseases, Kenneth R. McQuaid 63. Therapeutic & Toxic Potential of Over-the-Counter Agents, Robin L. Corelli 64. Dietary Supplements & Herbal Medications, Cathi E. Dennehy and Candy Tsourounis 65. Rational Prescribing & Prescription Writing, Paul W. Lofholm and Bertram G. Katzung 66. Important Drug Interactions & Their Mechanisms, John R. Horn Appendix: Vaccines, Immune Globulins, & Other Complex Biologic Products, Harry W. Palpiris and Daniel S. Maddix Index


AN EMERGING WASTING SYNDROME IN PEREGRINE FALCONS (Falco peregrinus) Richard Jones BVSc MSc MRCVS*,Neil Forbes BVetMed DipECZM(avian) FRCVS, Mark F. Stidworthy MA VetMB PhD FRCPath MRCVS and Tristan Cogan BSc PhD ABSTRACT Over the past 3 years approximately 30 adult peregrine and peregrine hybrid falcons from at least 3 separate collections as well as privately owned falconry birds in

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