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Microsoft word - muga, stephanie.doc

Stephanie J. Muga
Dept. of Biology & Geology, Chemistry & Physics
EDUCATION HISTORY
Dates

EMPLOYMENT HISTORY
Dates
USCA, Dept. of Biology. & Geology, Chemistry -Instructor MUSC, Dept. of Pharmacology, Charleston, SC USC School of Medicine, Dept. of Path, Micro. USC School of Medicine, Dept. of Dev. Biol. Univ. of Texas-Austin, Dept. of Human Ecology
HONORS AND AWARDS

• Sidney Kimmel Foundation for Cancer Research Nominee, 2002-2003. • Most Distinguished Postdoctoral Fellow for Excellence in Teaching. Univ. of Texas MD Anderson Cancer Center, Science Park Research Division. Smithville, TX, 1998-2000 • Postdoctoral Fellowship: NIH/NCI Training Grant in Carcinogenesis and Mutagenesis, Univ. of Texas, MD Anderson Cancer Center, Science Park-Research Division, Smithville, TX, 1996-1998 • AACR Molecular Biology and Pathology of Neoplasia Workshop Awardee, Keystone • Department of Education (GANN) Fellowship, University of Texas-Austin, Austin,TX, • Mathematics Internship Awardee, Univ. of North Carolina, Chapel Hill, NC, 1986 • Research Assistantship Awardee, Univ. of North Carolina, Institute of Marine Sciences,
PROFESSIONAL ORGANIZATIONS
• American Chemical Society: Member 1997-present • American Association for Cancer Research (AACR): Associate Member 1998-present • Women in Cancer Research (AACR): Member 1998-present • Molecular Epidemiology Working Group (AACR): Member 2001-present • South Carolina Cancer Alliance (SCCA) Member 2002-present • South Carolina Alliance for Cancer Chemoprevention (SCACC): Member 2002-present
EDITORIAL EXPERIENCE

Molecular Cancer Therapeutics, 2005-present
OTHER PROFESSIONAL ACTIVITIES
Grant
U.S. Civilian Research & Development Foundation (CRDF), for the Independent States of the Former Soviet Union, 2004-present. Ad Hoc Grant Reviewer American Cancer Society, 2001-present FORMAL TEACHING EXPERIENCE
University of Texas-Austin
1989-1991 Responsibilities: lectures and presentation of material, grading, tutorial exercises,
formulation and administration of exams. Courses:
Biochemistry Laboratory: basic principles of biochemistry and molecular
biology. Techniques: Southern, Northern and Western Analysis, Protein
Purification, Enzymatic Analysis and Kinetics, and PCR.
General Chemistry Laboratory: basic principles/techniques for chemical
analyses. Techniques and Topics; Acid/Base Chemistry, Titration Analysis,
Measurements and Weights, Calibration, Preparation of Buffers and Solutions.
Biophysical Principles of Biochemistry. Topics: applications of biophysical
analyses (i.e. spectroscopy, chromatography, crystallography, etc.) in understanding biochemical processes and functions within a cell. Introduction to Biochemistry; basic principles of biochemistry for pharmacy
students. Topics: DNA/RNA structure and analysis, protein
purification/analysis, enzyme kinetics, and introduction to genetic disorders in
human disease.
Biochemistry Laboratory for the Nursing Student: basic principles of
biochemistry. Topics: Acid/Base Chemistry, Preparation of Solutions,
Weights and Measurements, Titration analysis, DNA/RNA analysis, protein
analysis, and enzyme kinetics.

1990-1996
Supervision of undergraduate, graduate students, and technicians on various projects including folate metabolism in yeast, mechanisms of defective zinc transport in acrodermatitis enteropathica, message expression of the interleukin-1 family of proteins in mouse skin carcinogenesis, promoter walking/analysis of 8(S)-lipoxygenase.
University of Texas-MD Anderson Cancer Center, Smithville, TX
1996-2000
Supervision of undergraduate, graduate students, and technicians on various projects including message expression of the interleukin-1 family of proteins in mouse skin carcinogenesis, promoter walking/analysis of 8(S)-lipoxygenase. Founder, Organizer, and Lecturer: 1998 Summer Carcinogenesis Lecture
Series. University of Texas, MD Anderson Cancer Center, Science Park-Research Division, Smithville, Texas. Founder, Organizer, Lecturer: 1999 Summer Carcinogenesis Lecture Series
University of Texas, MD Anderson Cancer Center, Science Park-Research Division, Smithville, Texas. Founder, Organizer, and Lecturer: 2000 Summer Carcinogenesis Lecture
Series University of Texas, MD Anderson Cancer Center, Science Park-Research Division, Smithville, Texas
University of South Carolina School of Medicine
Fall 2001
PHAR 735: Cancer Biochemistry and Pharmacology, University of South Carolina, College of Pharmacy. Lecturer: Cancer Chemoprevention.
PATH 760/EPID 746: Topics in Pathobiology: Cancer Causes and Control and Cancer Epidemiology. University of South Carolina, School of Medicine and Arnold School of Public Health. Lecturer: Skin Cancer: Mechanisms and
Prevention.
BMSC 702 General Cell Biology, University of South Carolina, School of Medicine. Lecturer: Apoptosis.
Spring 2004 PATH 710: Cancer Biochemistry, University of South Carolina, School of Medicine. Lecturer: Cancer Chemoprevention.
PATH 760: Topics in Pathobiology: Cancer Causes and Control and Cancer Epidemiology. University of South Carolina, School of Medicine and Arnold
School of Public Health. Lecturer: Skin Cancer: Mechanisms and
Chemoprevention.
Spring 2006 PATH 710 Neoplasia, University of South Carolina, University of South Carolina, School of Medicine. Lecturer: Skin Cancer, Mechanisms, Human
Relevance and Prevention.

Supervisory Teaching
University of Texas-Austin
Graduate Students
Lisa Thurman Hotchkiss (PhD, withdrew: medical reasons)
University of Texas-MD Anderson Cancer Center
Graduate Students:

University of South Carolina, School of Medicine, SC Cancer Center
a) Advisory Committee (Supervisory Professor)
Graduate Students
Kathy Dozier (MS, education; research component, 2003) Patrick Angelos (BS, 2002): Dept of Biology (former Lee Mangiante (BS, 2004): graduate student at UNC-CH Dept. of Pathology, Robert H Wagner & Pogue Jeffrey Kent (BS, 2007): Undergraduate Research
Claflin University
Advisory Committee (Supervisory Professor)
Undergraduate Students
Honors Thesis

UNIVERSITY SERVICE

Faculty
Oversee safety committee members; monitor general safety procedures; maintain Chemical Hygiene Safety Manual & MSDS Manuals Maintain USC policy for proper use, disposal, and cleanup of radioactive cmpds for the floor
RESEARCH SUPPORT

ONGOING
Center for Colon Cancer Research
Franklin G. Berger, PhD (Overall
Stephanie J. Muga, PhD (PI): 40% (until 3/1/06) The major goal is to increase the number of NIH funded biomedical researchers in the State of
South Carolina via formation of a multidisciplinary research group (senior researchers/mentors,
junior/target faculty, core facilities, etc.) dedicated to studying colorectal cancer, its therapy, and
its prevention.
R21-CA107138
Michael J. Wargovich, PhD (PI)
Cancer Prevention by Traditional Medicinal Plants from West Africa The major goal of this project is to discover novel anti-inflammatory compounds from medicinal plants used in West Africa. Compounds from these plants may provide new strategies for use in chemoprevention in the treatment of colon cancer. It is widely known that long-term use of anti-inflammatory agents (i.e. non-steroidal anti-inflammatory drugs, NSAIDs), significantly decreases risk for onset of colon cancer. Many of these native West African plants are used in traditional medicine for a wide variety of ailments and illnesses. Therefore, this grant will explore which compounds within these plants are responsible for inhibition of inflammatory processes.
PENDING
R21 None Assigned
Yanqing Deng (PI)
Terahertz Imaging: A New Diagnostic Tool for Cancer This proposal is focused on developing a novel in vivo cancer imaging technologies in response to the NIH RFA PA-04-045. The objective of the proposal is to explore and develop a sub-terahertz and terahertz imaging system for prognostication and treatment of melanoma, colon cancer, and breast cancer. The sub-terahertz and terahertz imaging system utilizes electromagnetic waves at sub-terahertz and terahertz frequency range that is sandwiched between microwave and infrared light to obtain biomedical images of cancer tumors. The findings and outcome of the proposed research will facilitate surgeons and physicians in diagnosing and treating melanoma, colon cancer, and breast cancer, three of the most prevalent cancers in the United States. The proposed research will illuminate a new direction for biomedical imaging, which is supplement to X-rays and ultrasound.
COMPLETED
None Assigned
James A. Carson, PhD (PI)
South Carolina Nutrition Research Consortium (SCNRC) Interactive Effects of Nutraceutical and Physical Activity Treatments on APC Mouse Intestinal Polyp Formation and Growth The overall objective of this proposal is to determine if nutraceutical supplementation (curcumin, green tea, and quercetin) in combination with a physical activity intervention can decrease the effective dose of both treatments needed for chemoprevention of colon cancer progression, and determine if gender affects this response.
Supplement to COBRE Grant (P20 RR01 7698)
Frank Berger, PhD (overall PI)
The goal of this supplemental grant was to obtain funds to purchase an in situ PCR hybridization machine so that we can co-localize message and protein levels simultaneously within the same tissue.
01B097-REV2
Michael J. Wargovich, PhD (PI)
Herbal Supplements and Prevention of Colon Cancer The major goals of this project are to determine if certain herbal dietary supplements act like NSAIDs and have the ability to regulate cyclooxygenase, thus preventing colon cancer in a rat model. Do the Effects of Exercise on Breast Cancer Prevention Vary with Environment?
Jane Teas, PhD (PI)
The major goals of this project are to determine those factors, which regulate incidence or recurrence of breast cancer. Does exercise have a significant impact on regulating VEGF and HIF-A1 (hypoxia inducible factor 1 alpha) levels and does this contribute to the preventive effects of vitamin D metabolism on breast tumor development? R00-U21
Michael J. Wargovich, PhD (PI)
Stephanie J. Muga, PhD (Co-PI): 5% SC Research Initiative Grants Cancer Prevention Drug Discovery for Breast and Colon Cancer The major goal of this project is to establish an academic research drug discovery group at the University of South Carolina. Can Hyperbaric Oxygen Therapy Reduce Breast Cancer Treatment Related
Lymphedema?
Dick Clark, CHT (PI)
Stephanie J. Muga, PhD (Consultant/Collaborator): Palmetto Health Alliance Foundation Total The major goal of this pilot study is to investigate therapeutic potential and associated
angiogenic and lymphagiogenic responses, of hyperbaric oxygen therapy in lymphedema.
PPAR activators as chemopreventive agents of UV-induced skin carcinogenesis.
Stephanie J. Muga, PhD (PI): 20%
The major goal of this project was to test the effectiveness of topical application of peroxisome proliferator activated receptor ligands and retinoic acid to prevent skin tumor formation following UV-exposure.
PUBLICATIONS
PEER REVIEWED PUBLICATIONS
1. Baltgalvis KA, Berger FG, Pena MM, Davis JM, Muga SJ, Carson JA (2008). Interleukin-6
and cachexia in ApcMin/+ mice. American Journal of Physiology Regulatory Integrative Comparative Physiology. 294:R393-R401. Issa AY, Volate S, Muga SJ, Nicheva D, Smith T, Wargovich MJ (2007) Green tea
selectively targets initial stages of intestinal carcinogenesis in the AOM-ApcMin mouse model. Carcinogenesis 28(9): 1978-1984. 3. Androulakis XM, Muga SJ, Chen F, Koita Y, Toure B, Wargovich MJ (2006)
Chemopreventive effects of Khaya senegalensis bark extract on human colorectal cancer. Anticancer Res. 26 (3B): 2397-405. 4. Peng G, Dixon D, Muga SJ, Wargovich MJ (2006) Green tea polyphenol (-)-
epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis. Molecular Carcinogenesis, 45(5): 309-319. 5. Meeh PF, King M, O'brien RL, Muga S, Buckhalts P, Neuberg R, Lamb LS Jr.
Characterization of the gammadelta T cell response to acute leukemia. (2005) Cancer Immunol Immunother. 23:1-9. 6. He G, Muga S, Thuillier P, Lubet RA, Fischer SM. The effect of PPARγ ligands on UV-or
chemically-induced carcinogenesis in mouse skin. (2005), Molecular Carcinogenesis, 43(4): 198-206. 7. The PPARγ Pro12Ala Polymorphism and risk for incident sporadic colorectal adenomas. Gong, Z., Xie, D., Deng, Z., Bostick, RM, Muga, SJ, Hurley, TJ, Hebert, JR., (2005)
Carcinogenesis, 26(3):579-85.
8. Modulation of Aberrant Crypt Foci and Apoptosis by Dietary Herbal Supplements (Quercetin, Curcumin, Silymarin, Ginseng and Rutin). Volate, S, Davenport, DM, Muga,
SJ
, Wargovich, MJ. (2005), Carcinogenesis, 26(8): 1450-6.
9. Identification and characterization of a phorbol ester responsive element in the murine 8S- lipoxygenase gene. Kim, E, Muga, SJ, Fischer, SM. (2004) J. Biol. Chem, 279(12):
11188-97.
10. Characterization of the rat cytoplasmic C1-tetrahydrofolate synthase gene and analysis of its expression in liver regeneration and fetal development. Howard, KM, Muga SJ, Zhang,
L, Thigpen, AE, Appling, DR. (2003) Gene 319:85-97.
11. Bol, D. K., Rowley, R. Bruce, Ho, C.-P., Pilz, B., Dell, J., Swerdel, M., Kiguchi, K., Muga,
S., Klein, R., and Fischer, S.M. (2002) COX-2 overexpression in the skin of transgenic
mice results in suppression of tumor development. Cancer Res., 62: 2516-2521.
12. Thuillier, P., Anchiraico, G. J., Nickel, K. P., Maldve, R. E., Giminez-Conti, I., Muga, S. J.,
Liu, Kai-Li, Fischer, S. M., and Belury, M. A. (2000) Peroxisome proliferator activated
receptor (PPAR) alpha activators inhibit mouse skin tumor promotion. Molecular
Carcinogenesis,
29: 134-142.
13. Kleymenova, E., Muga, S. J., Fischer, S. M., and Walker, C. L. (2000) Application of
HPLC-based DNA Fragment Analysis (HADF) to Molecular Carcinogenesis. Molecular
Carcinogenesis
, Oct. 29(2): 51-58.
14. Muga, S. J., Thuillier, P., Pavone, A., Rundhaug, J. E., Jisaka, M., Boeglin, W., Brash, A.
R., and Fischer, S. M. (2000) 8S-lipoxygenase products activate PPARα and induce
differentiation in murine keratinocytes. Cell Growth and Differentiation, 11: 447-454.
15. Maldve, R. E., Kim, Y., Muga, S. J., and Fischer, S. M. (2000) Prostaglandin E2 regulation
of cyclooxygenase expression in keratinocytes is mediated via cyclic nucleotide-linked
prostaglandin receptors. J. of Lipid Research, Jun; 41(6): 873-81.
16. La, E., Muga, S. J., Fischer, S. M., and Locniskar, M. F. (1999) The altered expression of
Interleukin-1 receptor antagonist in different stages of mouse skin carcinogenesis.
Molecular Carcinogenesis, 24(4): 276-86.
17. Muga, S. J., and Grider, A. (1999) Partial characterization of a human zinc-deficiency
syndrome by differential display. Biological Trace Elements. Apr; 68(1): 1-12.
18. Chang, C., Muga, S. J., and Grider, A. (1998) Zinc uptake into fibroblasts is inhibited by
probenecid. Biochem. Biophys. Acta 1368: 1-6.
19. Grider, A., Lin, Y., and Muga, S. J. (1998) Differences in the cellular zinc content and
5′nucleotidase activity of normal and Acrodermatitis enteropathica fibroblasts following
treatment with medium containing different zinc concentrations. Biol. Trace Elem. Res.
61: 1-8.
20. Houck, K. A., Zarnegar, R., Muga, S. J., and Michalopoulos, G. (1990) Acidic fibroblast
growth factor (HBGF-1) stimulates DNA synthesis in primary rat hepatocytes. Journal of
Cellular Physiology,
143, 129-132.
21. Zarnegar, R., Muga, S. J., Rahija, R., and Michalopoulos, G. (1990) Tissue distribution of
Hepatopoietin A: A heparin binding growth factor for hepatocytes. Proceedings of the
National Academy of Sciences,
87: 1252-1256.
22. Zarnegar, R., Muga, S. J., Enghild, J., and Michalopoulos, G. (1989) Amino-terminal
amino acid sequence of rabbit Hepatopoietin A, a heparin-binding polypeptide growth
factor for hepatocytes. Biochemical and Biophysical Research Communications, 163(3):
1370-1376.
23. Cruise, J. L., Muga, S. J., Lee, Y. S., and Michalopolulos, G. (1989) Regulation of
hepatocyte growth: alpha-1 adrenergic receptor and ras p21 changes in liver regeneration.
Journal of Cellular Physiology, 140: 195-201.

ABSTRACTS
AACR
1. Zhang Q, Ford HY, Hudson RS, Muga SJ (2005) The effect of conjugated linoleic acid on
5-fluorouracil mediated apoptosis in HT-29 colon cancer cells 2. Hudson RS, Muga SJ (2005) Conjugated linoleic acid modulates eicosanoid signaling and
3. Volate SR Issa AY, Muga SJ, Wargovich MJ. (2005) Oncostatic Effects of Melatonin on
MCF-7 (ER+) and MDA-MB-231 (ER-) Breast Cancer Cell 4. Issa A, Volate S, Muga SJ, Wargovich MJ (2005) Green tea inhibits the formation of new
intestinal adenomas but not established tumors in the AOM-MIN mouse model 5. Androulakis XO, Muga SJ, Chen F, Koita Y, Toure B, and Wargovich MJ (2005) Khaya
senegalensis inhibits proliferation and induces apoptosis in colon cancer cell lines. 6. Muga SJ, Thuillier P, Zhang Q, Husdon RS, Martin P, McCauley E, Mangiante L (2004)
Effect of Dietary Conjugated Linoleic Acid on Apoptosis and Gene Expression in Colon. Orlando, FL. 7. Meeh PF, Muga SJ, O’Brien R, March JC, Wofford C, Neuberg R, and Lamb Jr LS (2004)
Gamma delta T cells from acute leukemia patients show restricted CDR3 rearrangements suggestive of a directed immune response. Orlando, FL. 8. Hudson RS, Mangiante L, Crook TM, Zhang JW, Wargovich MJ, and Muga SJ (2003)
Expression of Cyclooxyenase-2 in Mammary Glands and Tumors of Wnt-1 Transgenic Mice. 9. Muga, S. J., Brame, R. (2002) The role of 15-lipoxygenase-2 in human keratinocyte
differentiation and skin carcinogenesis. AACR Annual Meeting, San Francisco, CA. 10. Cohen J., Woods, CJ, Muga, S. J., Chapman, J, and Wargovich MJ (2002) Rosiglitazone,
an anti-diabetic ligand of peroxisome proliferator activated receptor gamma, promotes the development of aberrant crypt foci in F344 rats. AACR Annual Meeting, San Francisco, CA. 11. Thuillier, P., Belury, M. A., Muga, S. J., Klein, R., and Fischer, S. M. (2001) Activators of
PPARα partially inhibit mouse skin tumor promotion and stimulate keratinocyte differentiation. AACR Annual Meeting, New Orleans, LA. 12. Bol, D. K., Rowley, B., Ho, C-p., Dell, J., Pilz, B., Swerdel, M., Muga, S, and Fischer, S.
M. (2001) Cox-2 overexpression in the skin of Transgenic Mice Results in Reversible Alopecia and Suppression of Tumor Formation. AACR Annual Meeting, New Orleans, LA. 13. Hollis, D., Muga, S., and Wargovich, M. (2001) Structure-Activity Relationships of Garlic
Compounds and the Inhibition of Hepatic CYP2E1. AACR Annual Meeting, New Orleans, LA. 14. Muga, S. J, Kim, E., and Fischer, S. M. 8S-lipoxygenase regulation in mouse skin.
Proceeedings of the American Association for Cancer Research, 41, 84. AACR 2000,
San Francisco, CA.
15. Thuillier, P., Muga, S. J., and Fischer, S. M. Peroxisome proliferator activated receptor α
(PPARα) and lipoxygenase products activate keratinocyte differentiation. Proceeedings
of the American Association for Cancer Research
, 41, 11. AACR 2000, San Francisco,
CA.
16. Rundhaug, J. R., Muga, S. J., Walker, A. B., Gimenez-Conti, I., and Fischer, S. M.
Characterization of transgenic mice with dominant negative type I transforming growth
factor receptor-β targeted to the epidermis. Proceeedings of the American Association for
Cancer Research
, 41, 387 AACR 2000, San Francisco, CA.
17. Muga, S. J., Thuillier, P., Pavone, A., Rundhaug, J. E., Jisaka, M., Brash, A. R., and
Fischer, S. M. The function and mechanism of action of the products of 8(S)-
lipoxygenase products in skin. Proceeedings of the American Association for Cancer
Research
, 40, 368. AACR 1999, Philiadelphia, PA.
18. Thuillier, P., Maldve, R. E., Muga, S. J., Belury, M. A., and Fischer, S. M. Peroxisome
proliferator activated receptor (PPAR) expresssion is elevated in murine skin tumors.
Proceeedings of the American Association for Cancer Research, 40, 130. AACR 1999,
Philiadelphia, PA.
19. Muga, S. J., Pavone, A., Brash, A. R., and Fischer, S. M. (1998) Differential expression of
the 8(S)-lipoxygenase gene in SENCAR and C57BL/6J mice in response to phorbol
esters. Proceedings of the American Association for Cancer Research 39, 484; AACR
1998, New Orleans, LA.
20. Muga, S. J., Trimble, S., La, E., Lau, C., Fischer, S. M., and Locniskar, M. F. (1997)
Message Expression of Members of the Interleukin-1 Family in Mouse Skin after Treatment with Various Tumor Promoters. Molecular Biology and Pathology of Neoplasia Workshop, AACR, Keystone Resort, Keystone, CO.
South Carolina Alliance for Cancer Chemoprevention
21. Ford, HY, Hudson RS, Zhang Q, Mangiante L, and Muga SJ (2005) CLA Modulates Cell
Growth and 5-FU Mediated Apoptosis. 2nd Place Winner for Best Scientific Poster
($100.00).

22. Androulakis XQ, Muga SJ, Chen F, Koita Y, Toure B, Wargovich MJ (2005)
Chemopreventive Effects of Khaya snegalis bark extract on Colorectal Carcinoma Cells. 23. Zhang Q, Ford HY, Hudson RS, and Muga SJ (2005) The effect of CLA on 5-flurouracil-
mediated apoptosis in colon cancer cell lines. 24. Hudson RS, Wargovich MJ, and Muga SJ (2005) Conjugated Linoleic Acid modulates
prostaglandin signaling, ERK1/2 phosphorylation, and apoptosis in HCA-7 human colon cancer cells.
SC Nutrition Research Consortium Annual Meeting
25. Hudson RS, Muga SJ (2004) CLA Modulates Eicosanoid Signaling and ERK1/2
Phosphorylation in HCA-7 Cells. 1st Prize Winner for Best Scientific Poster ($75.00).
26. Zhang Q, Mangiante L, Muga SJ (2004) The effect of CLA on apoptosis and COX-2
27. Ford HY, Hudson RS, Zhang Q, Mangiante L, and Muga SJ (2004) CLA Modulates Cell
Growth and 5-FU-mediated apoptosis in Colon Cancer Cell Lines.

AICR (American Institute for Cancer Research) Annual Meeting

28. Ford HY, Hudson RS, Zhang Q, Mangiante L, Muga SJ (2004) Modulation of
Chemotherapy by Dietary Conjugated Linoleic Acid. Washington DC.
Keystone Symposium
29. Thuillier, P., Muga, S. J., Maldve, R. E., Belury, M., Brash, A. R., and Fischer, S. M. 8(S)-
lipoxygenase products activate PPARα and induce differentiation in murine keratinocytes. (1999) Keystone Symposia on Molecular & Cellular Biology. The PPARs: Transcriptional Links to Obesity, Diabetes, and Cardiovascular Disease. Keystone Resort, Keystone CO. 30. Thuillier, P., Belury, M. A., Muga, S. J., Klein, R., and Fischer, S. M. (2001) Activators of
PPARα partially inhibit mouse skin tumor promotion and stimulate keratinocyte differentiation. AACR Keystone Symposia, The PPARs: A Transcription Odyssey, Keystone Resort, Keystone, CO.
International Skin Carcinogenesis Conference
31. Thuillier, P., Belury, M. A., Muga, S. J., Klein, R., and Fischer, S. M. (2000) Activators of
PPARα partially inhibit mouse skin tumor promotion and stimulate keratinocyte differentiation. International Skin Carcinogenesis Conference, Tucson, AZ. 32. Rundhaug, J. E., Muga, S. J., Lee, M., Gimenez-Conti, I., and Fischer, S. M. (2000)
Expression of a truncated type I transforming growth factor-β (TGF-β) receptor in the skin of transgenic mice interferes with normal tail development. International Skin Carcinogenesis Conference, Tucson, AZ. 33. Fischer, S. M., Muga, S. J., Thuillier, P, Kim, E-J., and Brash, A. R. 8S-lipoxygenase
products activate peroxisome proliferator-activated receptor alpha, induce differentiation in murine keratinocytes, and causes progression of papillomas to carcinomas. International Skin Carcinogenesis Conference, 2000, Tucson, AZ.
Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Related Diseases
34. Muga, S. J., Thuillier, P., Pavone, A., Boeglin, W. R., Brash, A. R., and Fischer, S. M. 8S-
lipoxygenase products activate PPARα, induce differentiation, and enhance skin tumor development. Eicosanoid & Other Bioactive Lipids in Cancer, Inflammation, and Related Diseases. 6th International Conference, Boston, MA (1999) 35. Fischer, S. M., Thuillier, P., Muga, S. J., and Belury, M. A. PPAR expression and activity
in murine skin tumors. Eicosanoid & Other Bioactive Lipids in Cancer, Inflammation, and Related Diseases. 6th International Conference, Boston, MA (1999)
Experimental Biology: FASEB
36. Muga, S. J., Trimble, S., La, E., Lau, C., Fischer, S. M., and Locniskar, M. F. (1997)
Message Expression of Members of the Interleukin-1 Family in Mouse Skin after
Treatment with Various Tumor Promoters. The Faseb Journal: Abstracts, 11(3), A193;
Experimental Biology 97, New Orleans, LA.
37. Grider, A., Chen, C. Y., and Muga, S. J. (1997) Probenecid inhibits Zinc Transport in
Human Fibroblasts. The Faseb Journal: Abstracts, 11(3), A193; Experimental Biology
97, New Orleans, LA.
38. Muga, S. J., Trimble, S., La, E., Lau, C., Fischer, S. M., and Locniskar, M. F. (1996) The
Interleukin-1 System in Carcinogenesis: A Molecular Approach. International Skin Carcinogenesis Conference, Univ. of Texas, MD Anderson Cancer Center, Science Park-Research Division, Smithville-Bastrop, TX. 39. Muga, S. J., and Grider, A. (1996) Characterization of the Acrodermatitis Enteropathica
(AE) Mutation in Fibroblasts by Differential Display. The Faseb Journal: Abstracts,
10(3), A529; Experimental Biology 96 Meetings, Washington, D. C.
40. Carpenter, J., Freeland-Graves, J., Grider, A., and Muga, S. J. (1996) Development of a
Micro-Method for the Determination of Serum Arginase. The Faseb Journal: Abstracts,
10(3), A787; Experimental Biology 96 Meetings, Washington, D. C.
41. Zarnegar, R, Muga, S. J., and Michalopoulos, G. (1989) Hepatopoietin A: Isolation and
biological Properties. Proceedings of the American Association for Cancer Research. 30:
75.
42. Cruise, J. L., Muga, S. J., and Michalopoulos, G. (1988) Alpha-1 Adrenergic Receptors and
Phosphoinositide Turnover in Liver Regeneration. Faseb Proceedings Journal, 2(4),
A387.

MD Anderson Cancer Symposium
43. Hotchkiss, L. T., Muga, S. J., Sanders, B. G., and Kline, K. (1996) Differential Display
Analysis of VES effects on Signal Transduction in C4#1 Cells. MD Anderson Cancer Symposium, Houston, TX.
Other
44. Cruise, J. L., Muga, S. J., Fleischacker, D., and Michalopoulos, G (1990) Early Alterations
in ras p21 proteins in membranes of Regenerating Rat Liver. Journal of Cellular
Biochemistry: Abstracts,
14C: 160.
45. Cruise, J. L., Muga, S. J., Houck, K. A., and Michalopoulos, G. (1989) Uncoupling of
Adrenergic Receptors and changes in ras p21 levels during liver regeneration. ASCB/ASBMB meetings: poster.
INVITED SEMINARS AND COMPETITIVELY SELECTED ABSTRACTS
Invited Talk, Ohio State University, College of Human Ecology, Dept. of Human Nutrition, OSU Comprehensive Cancer Center. Columbus, Ohio. Conjugated Linoleic Acid: Anti-tumorigenic Mechanisms and Role in Modulating Colorectal Cancer Chemotherapy. Invited Talk, US CLA Network Meeting. Modulation of Chemotherapy by Conjugated Linoleic Acid. Sponsored by Loders-Crocklaan and Cognis, Inc. Indian Lakes Resort, Bloomingdale, IL. Ford, HY, Hudson RS, Zhang Q, Mangiante L, and Muga SJ (2005) CLA
Modulates Cell Growth and 5-FU Mediated Apoptosis. South Carolina
Alliance for Cancer Chemoprevention, Clemson University. 2nd Place Winner
for Best Scientific Poster ($100.00).

Muga SJ (2004) CLA Modulates Eicosanoid Signaling and
ERK1/2 Phosphorylation in HCA-7 Cells. SC Nutrition Research Consrotium
Research Summit, Columbia, SC. 1st Prize Winner for Best Scientific Poster
($75.00).

Invited Talk and Round Table Discussion: The PPARs and Eicosanoids in Skin Tumor Development, USC Dept. of Populations Studies and Epidemiology. Host: Dr. Roberd Bostick, University of South Carolina School of Medicine, SC Cancer Center, Columbia, South Carolina. 8S-lipoxygenase products activate PPARα, induce differentiation, and enhance tumor development in mouse skin. University of South Carolina at Columbia, School and Medicine and the South Carolina Cancer Center, Columbia, South Carolina. Hosts: Dr. Michael J. Wargovich, University of South Carolina at Columbia, School of Medicine and the South Carolina Cancer Center, Columbia, South Carolina. Summer Carcinogenesis Lecture Series, University of Texas, MD Anderson Cancer Center, Science Park-Research Division, Smithville, Texas. Faculty Sponsors: David Johnson, Ph.D. and Don Cook Lecture: Introduction to Cellular and Molecular Biology The function and mechanism of action of the products of 8(S)- lipoxygenase in skin. Experimental Skin Carcinogenesis Conference 1998, University of Texas, M. D. Anderson Cancer Center, Science Park-Research Division, Bastrop-Smithville, Texas. Hosts: Dr. Susan M. Fischer and Dr. Claudio Conti, University of Texas, MD Anderson Cancer Center, Science Park-Research Division, Smithville, Texas. Invited Talk: The role of 8(S)-lipoxygenase metabolic products in mouse skin carcinogenesis. University of Georgia, Athens, Georgia. Honorarium.Hosts: Dr. Roy Martin, Chairman and Director, Department of Foods and Nutrition, Dr. Arthur Grider, Assistant Professor, Department of Foods and Nutrition 1998 Summer Carcinogenesis Lecture Series, University of Texas, MD Anderson Cancer Center, Science Park-Research Division, Smithville, Texas. Faculty Sponsors: David Johnson, Ph.D. and Don Cook Lecture: Animal and Transgenic Animal Models in Carcinogenesis Interleukin-1: A Molecular Approach in Carcinogenesis. Molecular Biology Retreat, University of Texas, Institute of Cellular and Molecular Biology, Department of Microbiology, Bandera, Texas. Professional and Technical Consultation on Surgical Technique and Project Formulation and Experimentation. Hosts: Dr. Merle Olsen and Dr. Katherine M. Howard, Department of Biochemistry, University of Texas at San Antonio, Health Science Center, San Antonio, Texas. The Acrodermatitis enteropathica Mutation: A Model for Abnormal Zinc Transport. Host: Dr. Susan M. Fischer, Department of Carcinogenesis, University of Texas, MD Anderson Cancer Center, Science Park-Research Division, Smithville, Texas.

REFERENCES
DR. MICHAEL J. WARGOVICH, PHD
Director, Chemoprevention Program
SC Cancer Center
Professor, Department of Pathology, Microbiology & Immunology
University of South Carolina, School of Medicine
14 Medical Park, Suite 500
Columbia, SC 29202
Ph: 803.434.3925
FAX: 803.434.4359
Email: mwargovich@gw.mp.sc.edu

DR. LUCIA PIRISI-CREEK, MD
Interim Deputy Director for Research and Education
South Carolina Cancer Center
Senior Faculty Associate for Biomedical Research
USC Office of Research and Health Sciences
South Carolina Cancer Center Research Laboratories
14 Medical Park, Suite 500
Columbia, SC 29203-6877
Ph; .803.434.4278
Cell Phone: 803.269.8631
Fax: 803.434.3795
e-mail: Pirisi@med.sc.edu
DR. SUSAN M. FISCHER, PHD
Professor
Department of Carcinogenesis
University of Texas-MD Anderson Cancer Center
Science Park-Research Division
P.O. Box 389, 1808 Park Rd. 1C
Smithville, TX 78957
Ph: 512.237.9482
FAX: 512.237.9566
e-mail: smfischer@mdanderson.org

Source: http://www.usca.edu/biogeo/Vitae/MugaStephanie.pdf

All proposal (awarded_with co-i)original by lo.xls

List of Successful Projects in RGC GRF 2008-09Prof Sookja Kim Role of Epac1, cAMP-regulated guanine Mnucleotide exchange factor 1, in blood brain barrier maintenance, infarct and neurological deficits during ischemia/reperfusion injury probing their effects in glaucoma with transgenic mice over-expressing ET-1 in endothelial or glial cellsProf George Sai The role of STAT activation in regulati

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