Cool site pour acheter des pilules http://achetermedicaments2014.com/ Ne pas se perdre venir sur.
Microsoft word - summary research lambertsmuehle.doc
SUMMARY RESEARCH LAMBERTSMüHLE
Location and applied sanitation system:
Lambertsmühle is a historical water mill in Bergischen Land in Burscheid (neighbourhood Köln).
During its renovation it was decided to apply a decentralised sanitation concept mainly because the
connection to the sewer was too expensive. The starting point was separation of wastewater streams
based on their characteristics and their separate treatment. It was the first project in Germany dealing
with a separate collection of urine so from this point of view it was strategically important to
guarantee its success ensuring further development of this new trend in sanitation.
There were 3 wastewater streams separately collected: Sub-stream
Urine from no-mix toilets and urinals with or without flushing water
Faeces with flush water (minimal contribution of urine)
The treatment system for all the streams is shown in the Figure, further not explained in detail.
Toilets Various no-mix toilets were used; usually consuming 0.2 L to flush urine and 3-5 L to flush feaces. Brown water was collected with so called ‘Rottesack’ for thickening and pre-stabilisation of the content. The filtrate was directed together with grey water to the wetland system. Feaces stored for 6-12 months were further composted together with solid kitchen waste. Constructed wetland (soil or sand filter) Constructed wetland (vertical flow) was used to treat grey water and filtrate from brown water ‘bags’. Reed (phragmites australis
) was planted. The surface was calculated with assumption that 2 m2 is needed for 1 population equivalent. The gravel used to fill the filter had diameter between 2 and 8 mm to prevent the clogging.
Urine was stored in glass-fiber tank. Urine flow (yellow water) was approximately 20 L per day. The
storage volume was 4 m3 giving max storage time of 200 days. Results only on fate of pharmaceuticals
The research was performed from the end of 2001 till the beginning of 2003 (a bit more than 1 year).
There were 14 pharmaceutically active compounds (common pharmaceuticals) and/or their
metabolites (Table 1) and 7 steroids (Table 2) selected. The analytical methods based on GC-MS and
HPLC-MS (different for different group of compounds) were developed to measure these compounds
in difficult matrix of urine and wastewater.
Important: the wastewater streams were not spiked with the selected compounds. The found
pharmaceuticals were naturally present in the wastewater (visitors of the museum, employees,
Table 1: Selected pharmaceutically active compounds Compound
Metabolite of clofibrate, lipid lowering agent
Table 2 Steroids and their metabolites compound
The fate of pharmaceuticals and steroids was monitored in the following points of the system: For yellow water:
storage tank content, 2 periods 2 different pH (pH of 2 attained by addition of acids and natural pH of 8-9). (approximately 20 to 30 samples were analysed).
For remaining wastewater (filter from feces bags and grey water)
influent to the constructed wetland system
effluent from the constructed wetland system (6 times every two months, composite sample)
In addition some batch tests were performed to see the effect of pH on urine storage (6 months
storage, 3 measurements every 2 months). Urine (yellow water) line
Carbamazepine, clofibric acid and fenoprofen were found only in some influent samples. Diclofenac
and ibuprofen were present in higher concentrations throughout the whole period. Ibuprofen
concentrations showed a lot of variations. End May, beginning June and end June 2002 peak values of
ibuprofen were measured (186, 381 and 720 µg/L). The highest values of diclofenac were 28, 53 and
67 µg/L. Bezafibrate, indometacin, pentoxifyllin, phenacetin and phenazon were not found in the
influent. From steroids only natural steroid estron and β-sitosterol were found in the influent. Storage tank:
Clofibric acid was found in the tank only till December 2001 and fenoprofen was measured for a
relatively short time of approx. 3 months (January till March 2002). Carbamazepine was detected in
the period of September 2001 untill middle August 2002; concentrations were in the range between
0.8 µg/L upto 6.5 µg/L. After emptying the tank in August 2002, carbamazepine was found only once.
Ibuprofen and diclofenac was found in almost all samples from the storage tank. Diclofenac
concentration was relatively stable throughout the whole time (except of one value). From August till
January 2003 the avg. value of diclofenac increased when comparing with the previous research
period. (not really clear from Table).
It can be related to the increased pH value in the storage tank
preventing degradation of diclofenac (???), reported elsewhere in the report.
The concentration of ibuprofen in storage tank underwent strong variations. The influence of the
influent concentrations were clear to see. Concentration of ibuprofen was on its average factor 10
higher than other monitored pharmaceuticals. The remaining pharmaceuticals (from Tab 1) were not
detected in any of the samples. Only natural steroid estron and β-sitosterol were found in the storage
tank content. Results from in- and effluent of the wetland system (soil- sand filter for grey water and filtrate
The in- and effluent of the soil filter was investigated for the presence of pharmaceuticals and steroids.
The samples were taken in March 2002, in May, July, October, December, January 2002 mixed
weekly samples were taken. From pharmaceuticals, carbamazepin, diclofenac, ibuprofen, were
detected in the influent and effluent of the treatment unit. Phenazon was found just once, in both in-
and effluent samples.
Presence of these compounds in the soil filter can be explained by the presence of the examined
compounds also in feaces and/or not complete separation of urine from feces. Here, it has to be also
added that one conventional toilet was connected to the treatment system. Based on the ‘reduction’ of
investigated compounds in the soil filter, no final conclusions can be given, although the trend of very
low concentrations in the effluent is clear. From steroids, estron and β-sitosterol, were clearly present
in the influent. The estron concentrations between 1.6 and 10 µg/L were significantly lower than these
in urine storage tank. In the effluent the estron was hardly measured, meaning that it got almost
completely eliminated in the soil filter.
Based on the measurement of β-sitosterol in the in/ and effluent of the filter indicates its high
reduction, sometimes upto 80%. This result confirms the results obtained in municipal STPs.
Remarkable is a high increase of β-sitosterol in the influent to the wetland system starting from
October 2002. An explanation can be a use of another material for the compost bags for feaces (effect
Pharmaceuticals degradation in batch tests
In addition, batch tests into degradation of pharmaceuticals from urine in relation to pH. Urine
samples were put in batches at 2, 7 and 9. The samples were analysed in the beginning, after 3 and 6
months. A clear declining of measured pharmaceuticals was observed: For instance at pH = 2
indometacin was reduced with 30%, while carbamazepine, pentoxifyllin, phenazon, fenofibrate and
phenacetic between 45 – 70%. The diclofenac and ketoprofen were reduced up to 90%. Acetylsalicylic
acid was completely eliminated. Similar observations for other pH values. No comment on possible
transformations of considered compounds and/or abiotic changes. Conclusions and relevance to the research in Anderen
1. There were 14 (commonly used) pharmaceuticals and 7 steroids selected to follow their fate in
an alternative sanitation system comprising separate collection and treatment of three wastewater streams.
2. Analytical methods based on GC-MS were developed (two different procedures for sample
preparation both using solid phase extraction) for difficult matrix of urine and wastewater.
3. The influent was not spiked with pharmaceuticals
; pharmaceuticals and steroids were
naturally present (or not) in the influent.
4. No treatment system was used for urine (yellow water), only storage
5. Separate collection of (little diluted) urine allows to obtain the highest concentrations of
pharmaceutically active compounds and steroids (e.g. ibuprofen up to 700 µg/L) when comparing with traditional sanitation concept.
6. Pharmaceuticals were monitored in the influent to- and in the storage tank content,
where, in fact, not much is expected to happen.
7. Effect of pH on the selected compounds in separately collected urine was in addition
examined; expecting some effect on the reduction of the considered compounds; there is no comment on possible transformation of parent compound; the conditions of the experiment are not described in detail – possible other abiotic reaction may occur (e.g. photolysis).
8. In addition the influent and effluent from the sand filter (soil filter, constructed wetland with
reed plants) treating grey water and feaces filtrate was measured for presence (and reduction) of pharmaceuticals and steroids. Only few pharmaceuticals and 2 steroids were detected in low concentrations. Presence of pharmaceuticals and steroids in this treatment line can be explained by the fact that some pharmaceuticals and steroids are excreted also with feaces, the separation of urine in no-mix toilet is never complete and contribution of urine from one conventional toilet used in Lambertsmühle. Reduction of detected compounds was observed, sometimes significant.
9. The applied in Lambertsmühle wetland system is not comparable to soil filter with energy
crops to be applied in Anderen (e.g. large diameters of filter media, restricted depth, different type of crop, very different loading rate and composition of the influent- in Lambertsmuhle continuous inflow of wastewater containing little nutrients and micropollutants; Anderen – 1 a 2 times per year loaded + effect of rain).
Immunosuppressant treatment 1. Identification and description of the procedure The immunosuppressant treatment consists in administering pharmaceutical intravenously or orally amongthose corticoids, cyclophosphomide, azathioprine, mycophenalate, cycloseporine, chlorambucil, tacrolymus,rapamycin and others. Your team of nephrologists will have informed you of the disease you are sufferingfr
Kosttillskottet MSM – organiskt svaveloch metyl – tas bäst upp i kroppen omdet intas i pulverform. Av artikeln kom-mer det att framgå att det har en radpositivia effekter på många av kroppensfunktioner. MSM – organiskt svavel och metyl – viktigt näringsämne för hela kroppenDet finns ett ämne som gör håret starkare och mer levande, naglarnahud, hår och naglar. Hälften av