Ogi.htm

Olaf-Georg Issinger: List of publications
138. Persson, T., Yde, C.W., Rasmussen, J.E., Rasmussen, T.L., Guerra, B., Issinger, O.-G., and Nielsen J. (2007) Carboxyl and arboxamide pyrazoles as protein kinase inhibitors in corrupt eukaryotic signal transduction: Induction of growth arrest in MCF-7 cancer cel s. Organic & Bioorganic Chemistry, in press 137. Yde, C.W., Frogne, T, Lykkesfeldt, AB, Fichtner, I., Issinger, O.-G., and Stenvang J. (2007) Induction of cel death in antiestrogen-resistant human breast cancer cel s by the protein kinase CK2 inhibitor 136. Yde, C.W., Gyrd-Hansen, M., Lykkesfeldt, A.E., Issinger, O.-G.and Stenvang, J. (2007) Breast
cancer cel s with acquired anti-estrogen resistance are sensitized to cisplatin-induced cel death.
Mol. Cancer Therapeutics, 6, 1869-1876.
135. Niefind, K., Yde, C.W., Ermakova, I, and Issinger, O.-G. (2007) Evolved to be active: CK2alpha and its exceptional role within the CMGC family of eukaryotic protein kinases.
134. Olsen, B.B., Neves-Petersen, T., Klitgaard, S., Issinger, O.-G., and Petersen S.B. (2007) UV-induced light il umination blocks EGFR signaling in human cancer cel lines. 133. Yde, C.W. and Issinger, O.-G. (2006) Protein profiling of different human breast cancer cel lines in
response to cisplatin treatment and validation of anti-apoptotic Bcl-2 as a target for enhancing cisplatin 132. Olsen, B.B., Pedersen J. and Issinger, O.-G. (2006) BID, substrate and interaction partner for 131. Olsen, B.B., Boldyreff B., Niefind, K., and Issinger, O.-G. (2006) Purification and characterization of the
CK2a'-based holoenzyme, an isozyme of CK2a: A comparative analysis. Protein Expression and Purification, 47, 651-661.
130. Skjøth, I.E.H. and Issinger, O.-G. (2006) Profiling of signaling molecules in four different human prostate carcinoma cel lines before and after induction of apoptosis. 129. Olsen, B., Niefind, K., and Issinger, O.-G. (2006) Inter- and Supramolecular Interactions of Protein Kinase CK2 and their Relevance for Genome Integrity in: Genome Dynamics and Stability, Facets of Genome Integrity, Springer Verlag, 315-342.
128. Seeber, S., Issinger, O.-G., Holm, T., Christensen, L.P., and Guerra, B. (2005) Validation of protein 127. Bjørling-Poulsen, M., Meek, D, and Issinger, O.-G. (2005) CHK2 and HDM2 interact in vitro and in mammalian cel s and HDM2 negatively affects the CHK2-mediated phosphorylation of p53.
126. Bjørling-Poulsen, M., Siehler,S., Wiesmül er, L., Meek, D., Niefind, K., and Issinger, O.-G. (2005) The
regulatory beta-subunit of protein kinase CK2 negatively influences p53-mediated al osteric effects on Olaf-Georg Issinger: List of publications
125. Rasmussen, T., Jensen H.H., Niefind, K., Boldyreff, B., and Issinger O.-G. (2005) Biochemical characterization of the human homologues of Drosophila andante and timekeeper proteins.
124. Blond, O., Jensen, H.H., Buchou, T., Cochet, C., Issinger, O.-G., and Boldyreff, B. (2005) Knocking
out the regulatory beta subunit of protein kinase CK2 in mice: gene dosage effects in ES cel s and 123. Niefind, K. and Issinger, O.-G. (2005) Neglected and overseen aspects of CK2 structure.
122.Yde C.W., Ermakova, I., Issinger, O.G., and Niefind K. (2005) Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a 121. Kristensen, LP., Larsen, M.R., Højrup, P., Issinger, O.-G., and Guerra,B. (2004) Phosphorylation of the regulatory beta-subunit of protein kinase CK2 by CHK1:identification of the in vitro CK2 beta 120. Ermakova, I., Boldyreff, B., Issinger, O.-G., Niefind, K. (2003) Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit 119. Olsen, B.B., Jessen V., Højrup, P., Issinger, O.-G., Boldyreff, B. (2003) Protein kinase CK2 phosphorylates the Fas-associated factor FAF1 in vivo and influences its transport into the nucleus.
118. Nastainczyk, W., Issinger, O.-G., Guerra, B. (2003) Identification of the antigenic determinant of monoclonal anti CK2alpha antibody 1AD9.
117. Bjørling-Poulsen, M. and Issinger, O.-G. (2003) cDNA array analysis in gene expression in the promyelotic leukemia cel line, HL60, after apoptosis induction with etoposide.
116. Guerra, B., Issinger, O.-G. and Wang, Y.J (2003) Modulation of human checkpoint kinase Chk1 by the regulatory $-subunit of protein kinase CK2.
115. Bjørling-Poulsen, M.,, L. Seitz, G., Guerra, B. and Issinger, O.-G. (2003) Fas-associated factor 1 is specifical y degraded in human stomach tumors.
114. Riera, M., Pages, M., Issinger O.-G, and Guerra, B. (2003) Purification and Characterization of recombinant Protein Kinase CK2 from Zea mays Expressed in E. coli.
Protein Expression and Purification, 29, 24-32.
113. Buchou T., Vernet, M., Blond, O., Jensen, H.H., Pointu, H., Olsen, B.B., Cochet, C., Issinger, O.-G., Boldyreff, B. (2003) Disruption of the regulatory beta-subunit of protein kinase CK2 in mice leads to a cel - Olaf-Georg Issinger: List of publications
autonomous defect and early embryonic lethality.
112. Tchorzewski, M., Krokowski, D., Rzeski, W., Issinger, O.-G. and Grankowski, N. (2003) The subcel ular distribution of the human ribosomal "stalk" components: P1, P2 and P0 proteins.
Int. J. Biochem. & Cel. Biol. 35, 203-211.
111. Andersen, T.E., Finsen, B., Goffinet, A.M., Issinger, O.-G., and Boldyreff B. (2002) A reeler mutant mouse with a new, spontaneous mutation in the reelin gene.
Brain Res. Molecular Brain Res. 105, 153-156.
110. Kalmykova, A.I., Shevelyov, Y.Y., Polesskaya, O.O., Dobritsa, A.A., Evstafieva, A.G., Boldyreff, B., Issinger, O.-G., and Gvozdev, V.A. (2002) CK2$tes gene encodes a testis-specific isoform of the regulatory subunit of casein kinase 2 in Drosophila melanogaster. 109. Guerra, B., Boldyreff, B., Issinger, O.-G. (2001) Fas-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction.
108. Guerra, B., Niefind, K., Ermakowa, I., and Issinger, O.-G. (2001) Characterization of CK2 holoenzyme variants with regards to crystal ization , 107. Niefind, K., Guerra, B., Ermakova, I., Issinger, O.-G. (2001) Structure of human CK2: insights into basic properties of the CK2 holoenzyme.
106. Hjerrild, M., Milne, D., Dumaz, N., Hay, T., Issinger, O.-G., and Meek, D. (2001) Phosphorylation of MDM2 at serine 267 by protein kinase CK2 in vitro and in cultured cel s.
105. Roher, N., Miro, F., Boldyreff, B., Plana, M., Issinger, O.-G., and Itarte, E. (2001) The carboxy-terminal domain of human grp94 protects the catalyutic subunit of protein kinase CK2 (CK2alpha) against thermal Eur. J. Biochem. 268, 423-436.
104. Kriajevska, M., Bronstein, I., Scott, D., Tarabykina, S., Fischer-Larsen, M., Issinger, O.-G, Lukanidin, E.(2000) Metastasis-associated Mts1 (S100A4) inhibits CK2-mediated phosphorylation and self-assembly of the heavy chain of nonmuscle myosin. Biochim. Biophys. Acta, 1498, 252-263.
103. Battistutta, R., Sarno, S., De Moliner, E., Marin, O., Issinger, O.-G., Zanotti, G., and Pinna, L.A. (2000) The dimeric structure of the alpha-subunit in complex with two beta-peptides reveals an intriguing 102. Niefind, K., Guerra, B., Ermakowa, I., and Issinger, O.-G. (2000) Crystal ization and Characterization of Crystals of Human Protein Kinase CK2 Holoenzyme.
Acta Crystal ographica, Section D, 56, 1680-1684. 101. Tchorzewski, M., Boldyreff, B., Issinger, O.-G., and Grankowski, N. (2000) analysis of the protein- protein interactions between the human acidic ribosomal P-proteins: evaluation by the two hybrid system. Int. J. Biochem. & Cel. Biol. 32, 737-746.
Olaf-Georg Issinger: List of publications
100. Sayed, M., Kim, S. O., Baljinder, S. S., Issinger, O.-G., and Pelech, S. (2000) Stress Induced Activation of Protein Kinase CK2 by direct interaction with p38 MAP Kinase. 99. Nielsen, J., Lyngsø, L.O., and Issinger, O.-G. (1999) Benzoylaminopyrimidine derivatives as potential 98. Guerra, B., Siemer, S., Boldyreff, B. and Issinger, O.-G. (1999) Protein kinase CK2: evidence for a protein kinase CK2$-subunit fraction, devoid of the catalytic CK2"-subunit, in mouse brain and testicles. 97. Peracchia, G., Jensen, A.B., Culianez-Macia, F.A., Grosset, J., Goday, A., Issinger, O.-G., and Pages, M. (1999) Characterization, subcel ular localization and nuclear targeting of casein kinase 2 from Zea 96. Niefind, K., Puetter, M., Guerra, B., Issinger, O.-G. and Schomburg, D. (1999) GTP plus water mimics ATP in the active site of protein kinase CK2. Nature Structural Biology 6, 1100-1103.
95. Siemer, S., Ørnskov, D., Boldyreff, B., Guerra, B., and Issinger, O.-G. (1999) Cisplatin and carboplatin induce apoptosis in murine teratocarcinoma cel line F9: characterization of p53, MDM2 and protein kinase Int. J. of Biochem. & Cel Biol. 31, 661-670.
94. Guerra, B., Boldyreff, B., Sarno, S., Cesaro, L., Issinger, O.-G., and Pinna, L. A. (1999) CK2: A protein 93. Guerra, B. and Issinger, O.-G. (1998) p53 and the ribosomal protein L5 participate in high molecular mass complex formation with protein kinase CK2 in murine teratocarcinoma cel line F9 after serum stimulation and cisplatin treatment.
92. Kusk, M., Ahmed, R., Thomsen, B., Bendixen, C., Issinger, O.-G., and Boldyreff, B. (1998) Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins.
Molecular and Cel ular Biochemistry, 191, 51-58 92. Niefind, K., Guerra, B., Pinna, L.A., Issinger, O.-G., and Schomburg, D. (1998) Crystal structure of the catalytic subunit of protein kinase CK2 from Z. Mays at 2.1Å resolution.
91. Guerra, B., Niefind, K., Pinna, L.A., Schomburg, D., and Issinger O.-G. (1998) Expression, purification and crystal ization of the catalytic subunit of protein kinase CK2 from Zea Mays. 90. Winter, B., Kautzner, I., Issinger, O.-G., Arnold, H.-H. (1997) Two putative protein kinase CK2 phosphorylation sites are important for Myf-5 activity. 89. Sarno, S., Marin, O., Meggio, F., Issinger, O.-G. and Pinna, L.A. (1997) Basic residues in the 74-77 and 191-198 segments of protein kinase CK2 catalytic subunit are implicated in negative but not in positive Olaf-Georg Issinger: List of publications
88. Sarno, S., Vaglio, P., Marin, O., Issinger, O.-G., Ruffato, K., and Pinna, L.A. (1997) Mutational analysis of residues implicted in the interaction between protein kinase CK2 and peptide substrates. 87. Boldyreff, B. and Issinger, O.-G., (1997) The regulatory subunit of protein kinase CK2 is a specific 86. Guerra, B., Götz, C. Wagner, P., Montenarh, M, and Issinger, O.-G. (1997) The carboxy terminus of p53 mimicks the polylysine effect of protein kinaseCK2-catalyzed MDM2 phosphorylation. 85. Koenig, M. G., Sturm, D., Prowald, A., Issinger, O.-G. and Montenrah, M. (1997) Interaction of p53 with protein kinase CK2 during SV40 induced entrance of quiescent cel s into the cel cycle. 84. Sarno, S., Vaglio, P., Meggio, F., Issinger, O.-G., and Pinna, L. A. (1996) Protein kinase CK2 mutants defective in substrate recognition: purification and kinetic analysis.
83. Siemer, S., Stalter, G., Ziegler, M., and Issinger, O.-G. (1996) Characterization of protein kinase CK2 in 82. Biondi, R.M., Engel, M., Sauane, M., Welter, C., Issinger, O.-G., Asua, L.J., and Passeron, S. (1996) Inhibition of nucleoside diphosphate kinase activity by in vitro phosphorylation by protein kinase CK2.
Differential phosphorylation of NDP kinases in HeLa cel s in culture. 81. Biondi, R. M., Walz, K., Issinger, O.-G., Engel, M., and Passeron, S. ( 1996) Discrimintion between acid and alkali labile phosphorylated residues on immobiol: phosphorylation sutdies for nucleoside diphosphate 80. Vaglio, P., Sarno, S., Marin, O., Meggio, F., Issinger, O.-G., and Pinna, L.A. (1996) Mapping the residues of protein kinase CK2 subunit responsible for responsiveness to polyanionic inhibitors.
79. Boldyreff, B., Mietens, U., and Issinger, O.-G. (1996) Structure of protein kinase CK2: dimerization of 78. Sarno, S., Vaglio, P., Meggio, F., Issinger, O.-G., and Pinna, L.A. (1996) Protein kinase CK2 mutants 77. Götz, C., Wagner, P., Issinger, O.-G., and Montenarh, M. (1996) p21WAF1/CIP1 interacts with protein Olaf-Georg Issinger: List of publications
76. Rosorius, O., Issinger, O.-G., and Braulke, T. (1996) Brain-specific interaction of a 91-kDa membrane-bound protein with the cytoplasmic tail of the 300-dDa mannose- 6-phosphate receptor.
Biochem. Biophys. Res. Commun. 221, 525-530 75. Issinger, O.-G. (1995) Casein kinase 2 (rmCK-2 , Zea mays), in : The Protein Kinase Factsbook, ed.
Hardie D.G. and Hanks, S.K., Academic Press.249-251 Olaf-Georg Issinger: List of publications
74. Siemer, S., Kriener, S., Remberger, K., and Issinger, O.-G. (1995) Influence of indomethacin and difluoromethylornithine on human tumor growth in nude mice. 73. Nastainczyk, W., Schmidt-Spaniol, I., Boldyreff, B. and Issinger, O.-G. (1995) Isolation and characterization of a monoclonal anti protein kinase CK2ß subunit antibody of the IgG class for the direct detection of CK2ß subunit in tissue cultures of various mammalian species and human tumors.
72. Boldyreff, B. and Issinger, O.-G. (1995) Structure of the gene encoding the murine protein kinase CK2.
71. Bozzetti, M. P., Massari, S., Finel i, P., Meggio, F., Pinna, L., Boldyreff, B., Issinger, O.-G., Palumbo, G., Ciriaco, C., Bonacorsi, S., and Pimpinel i, S. (1995) The Ste locus, a component of the cry-Ste selfish system of D. melanogaster, encodes a protein mimicking some properties of the ß-subunit of protein 70. Meggio, F., Boldyreff, B., Marin, O., Issinger, O.-G., and Pinna, L.A. (1995) Phosphorylation and activation of protein kinase CK2 by p34cdc2 are independent events.
69. Marin, O., Meggio, F., Boldyreff, B., Issinger, O.-G., and Pinna, L. A. (1995) Dissection of the dual function of the ß-subunit of protein kinase CK2 ("casein kinase-2"). A synthetic peptide reproducing the carboxyl terminal domain, mimicks the positive but not the negative effects of the whole protein.
68. Siemer, S., Ziegler, M., Remberger, K., and Issinger, O.-G. (1995) Influence of indomethacin and alpha-didluoromethylornithine on renal tumor growth and protein kinase CK2 activity in nude mice.
67. Sarno, S., Boldyreff, B., Marin, O., Guerra, B., Meggio,F., Issinger, O.-G., and Pinna, L. A. (1995) Mapping the residues of protein kinase CK2 implicated in substrate recognition. Alanine scan mutagenesis of conserved basic residues in the alpha-subunit. Biochem. Biophys. Res. Commun. 206, 171-179.
66. Hoffman, U., Boldyreff, B., and Issinger, O.-G. (1995) Characterization of three pseudogenes from Biochim. Biophys. Acta, 1260, 337-340.
65. Schmidt-Spaniol,I. and Issinger, O.-G. (1994) Bestimmung der Proliferation von CHO-AA8-Zel en nach cisplatin-Behandlung mit Hilfe des 5-Bromo-2'-deoxy-uridine Labeling and Detection Kit III. Boehringer Mannheim Biochemica Information 94, 16-17.
64. Engel, M., Issinger, O.-G., Lascu, I., Seib, T., Dooley, S., Zang, K.D., and Welter, C. (1994) Phosphorylation of NM23/nucleoside diphosphate kinase by CK2 in vitro.
Biochem. Biophys. Res. Commun. 199, 1041-1048.
63. Boldyreff, B., Meggio, F., Pinna, L.A., and Issinger, O.-G. (1994) Protein kinase CK2 structure-function relationship: effects of the ß- subunit on reconstitution and activity.
62. Küpper, M., Köster, M Schmidt-Spaniol, I., Wagner-Gil en, I, and Issinger, O.-G. (1994) Olaf-Georg Issinger: List of publications
Characterization of protein kinase CK2 protein subunits and p53 in F9 teratocarcioma cel s in the absence 61. Stalter, G., Siemer, S., Becht, E., Ziegler, M., Remberger, K., and Issinger, O.-G. (1994) Asymmetric distribution of CK-2 subunits in human kidney tumours when compared to the ipsilateral Biochem. Biophys. Res. Commun 202, 141-147 60. Schmidt-Spaniol, I. Grimm, B., and Issinger, O.-G. (1994) Subcel ular localization of CK-2 subunits Molecular and Cel ular Biology Research 39, 761-772 59. Meggio, F., Boldyreff, B., Issinger, O.-G., and Pinna, L. A. (1994) Calmodulin phosphorylation by CK-2 and responsiveness to polybasic effectors are deeply affected by mutations of the ß-subunit involving the 58. Singh, S., Jantke, I., Simon, M., Meybohm, I., Boldyreff, B., Issinger, O.-G., and Goedde, H. W. (1994) Pst1 identifies a bial elic DNA polymorphism of human casein kinase 2 gene.
57. Wagner, P., Appel, K., Issinger, O.-G. , and Montenarh, M. (1994) On the interaction of p53 with CK-2. International Journal of Oncology 4, 491-498 56. Boldyreff, B., Meggio, F., Pinna, L. A., and Issinger (1994):Efficient autophosphorylation and phosphorylation of the ß-subunit by CK-2 require the integrity of an acidic cluster 50 residues downstream 55. Mestres, P. Boldyreff, B., Epensberger, C., Hameister, H., and Issinger, O.-G., (1994): Expression of 54. Boldyreff, B., James, P., Staudenmann, W., and Issinger, O.-G.(1993) Ser2 is the autophosphorylation site in the ß-subunit from bicistronical y expressed human CK-2 and from native rat liver CK-2ß.
53. Boldyreff, B., Meggio, F., Pinna, L. A. and Issinger, O.-G. (1993): CK-2 structure-function relationship: Reconstitution of normal and hyperactivating forms of CK-2 ß by variably mutated 52. Grankowski, N., Gasior, E., and Issinger, O.-G. (1993)Synthetic peptides and ribosomal proteins as substrates for 60Sribosomal protein kinase from yeast cel s. 51. Rosorius, O., Issinger, O.-G., and Braulke, T. (1993) Phosphorylation of the cytoplasmic tail of the 300-kDa mannose 6-phosphate receptor is required for the interaction with a cytoplasmic protein.
50. Meggio, F., Boldyreff, B., Issinger, O.-G., and Pinna, L. A. (1993) The autophosphorylation and p34cdc2 phosphorylation sites of CK-2-ß-subunit are not essential for reconstituting ful y Olaf-Georg Issinger: List of publications
Biochim. Biophys. Acta, 1164, 223-225.
49. Rosorius, O., Mieskes, G., Issinger, O.-G., Körner, C., Schmidt, B., v. Figura, K., and Braulke, T. (1993) Characterization of phosphorylation sites in the cytoplasmic domain of the 300 kDa mannose 6-phosphate receptor. 48. Boldyreff, B., Meggio, F., Dobrowolska, G., Pinna, L. A., and Issinger, O. G. (1993): Expression and characterization of a recombinant maize CK-2 subunit. 47. Lorenz, A., Herrmann, C. P., Issinger, O. G., and Montenarh, M. (1992): Phosphorylation of wild-type and mutant phenotypes of p53 by an associated protein kinase. 46. Boldyreff, B., Meggio, F., Pinna, L. A., and Issinger, O. G. (1992): CK-2 structure function relationship: 1.
creation of a set of mutants of the ß-subunit that variably surrogate the Biochem. Biophys. Res.Commun. 188, 228-234.
45. Grässer, F. A., Göttel, S., Haiss, P., Boldyreff, B., Issinger, O. G., and Mül er-Lantzsch, N. (1992): Phosphorylation of the Epstein-Barr virus nuclear antigen 2. Biochem. Biophys. Res. Commun., 186, 1694-1701 .
44. Boldyreff, B., Wehr, K., Hecht, R., and Issinger, O. G. (1992): Identification of four genomic loci highly related to CK-2 cDNA and characterization of a CK-2 pseudogene within Biochem. Biophys. Res. Commun. 186, 723-730 43. Meggio, F., Boldyreff, B., Marin, O., Marchiori, F., Perich, J. W., Issinger, O. G., and Pinna, L. A. (1992): The effect of polylysine on CK-2 activity is influenced by both the structure of the protein/peptide substrates and subunit composition of the enzyme. 42. Boldyreff, B., Klett, C., Göttert, E., Geurts van Kessel, A., Hameister, H., and Issinger, O. G. (1992): Assigment of casein kinase 2 sequences to two different human chromosomes. 41. Schmidt-Spaniol, I., Boldyreff, B., and Issinger, O. G. (1992): Isolation and characterization of a monoclonal anti CK-2 -subunit of the IgG1 subclass. 40. Meggio, F., Boldyreff, B. S., Marin, O., Pinna, L. A. and Issinger, O. G. (1992): CK-2: role of the ß-subunit on the stability and specificity of the recombinant reconstituted 39. Issinger, O. G., Brockel, C., Boldyreff, B.S., and Pelton, J. T. (1992): Effects on the secondary structure of recombinant casein kinase II and beta subunits after reconstitution in 38. Dobrowolska, G., Boldyreff, B., and Issinger, O. G. (1991): Cloning and sequencing of CK-2 alpha - Olaf-Georg Issinger: List of publications
37. Grankowski, N., Boldyreff, B., and Issinger, O. G. (1991): Isolation and characterization of recombinant human CKII subunits and from bacteria. Eur. J. Biochem. 198, 25-30.
36. Boldyreff, B., Piontek, K., Schmidt-Spaniol, I., and Issinger, O. G. (1991): The beta-subunit of CK II: cloning of cDNAs from murine and porcine origin and expression of the porcine sequence as a fusion protein.
Biochim. Biophys. Acta 1088, 439-441.
35. Pistorius, K., Seitz, G., Remberger, K., and Issinger, O. G. (1991): CK II is sequential y elevated in colonic mucosa and neoplasias (adenoma/carcinoma sequence). 34. Menzel, A., Lagoda, P., and Issinger, O. G. (1990): Hypervariable individual-specific DNA banding pattern revealed by a 22mer promoter-specific oligonucleotide probe conteining an SP1 33. Türeci, Ö., Fischer, H., Lagoda, P., and Issinger, O. G. (1990): Characterization of human glioblastoma cel lines in vitro and their xenografts in nude mice by DNA fingerprinting. 32. Grankowski, N. and Issinger, O. G. (1990): Subcel ular localization of CK-1. Biochem. Biophys. Res. Commun. 167, 471-476 31. Münstermann, U., Fritz,G.,Seitz, G., Yiping, L., Schneider, H. R., and Issinger, O. G. (1990): CK II is elevated in solid tumours and rapidly proliferating non-neoplastic tissue. 30. Lagoda, P. J. L., Seitz, G., Epplen, T. J., and Issinger, O. G. (1989): Increased detectability of somatic changes in the DNA from human tumours after probing with "synthetic" and "genome-derived" hypervariable multilocus probes.
29. Schneider, H. R., and Issinger, O. G. (1989): Growth-dependent modulation of CK II in primary cel Biochim. Biophys. Acta 1014, 98-100.
28. Seitz, G., Münstermann, U., Schneider, H. R., and Issinger, O. G. (1989): Characterization of casein kinase II in human colonic tumours after heterotransplantation into nude mice. Biochem. Biophys. Res. Commun. 163, 635-641 27. Schneider, H. R., Mieskes, G., and Issinger, O. G. (1989): Specific dephosphorylation by phosphatases 1 and 2A of a nuclear protein structural y and immunological y related to nucleolin.
Possible influence on the regulation of rRNA synthesis. 26. Schneider, H. R., and Issinger, O. G. (1988): Nucleolin (C23), a physiological substrate for casein Biochem. Biophys. Res. Commun. 156, 1390-1397.
25. Issinger, O. G., Martin, T., Richter, W. W., Olson, M., and Fujiki, H. (1988): Hyperphosphorylation of N-60, a fragment of nucleolin after tumour treatment. Olaf-Georg Issinger: List of publications
24. Schneider, H. R., Reichert, G. H., and Issinger, O. G. (1986): Enhanced CK-II activity during mouse embryogenesis: identification of a 110 kDa phosphoprotein as the major phosphorylation product in mouse embryos and Krebs II mouse 23. Richter, W. W. and Issinger, O. G. (1986): Differential heat shock respone of primary human cel Biochem. Biophys. Res. Commun. 141, 46-52.
22. Rance, A., Thönnes, M., and Issinger, O.G. (1985): Ribosomal protein S6 phosphorylation and morphological changes in response to the tumour promoter TPA in primary and human tumour cel s, established and transformed cel lines.
21. Reichert, G. and Issinger, O.G.(1985): In vitro study on the biological activity of RNAs after incubation of hog liver, heart and brain tissue at room temperature. 20. Prowald, K., Fischer, H., and Issinger, O.G. (1984): Enhanced casein kinase II activity in human tumour 19. Unteregger, G., Zang, K. D., and Issinger, O. G. (1983): Nuclear proteins in human meningiomas. 18. Richter, W. W., Zang, K. D., and Issinger (1983): Influence of hyperthermia on the phosphorylation of ribosomal protein S6 from human skin fibroblasts and meningioma cel s. 17. Beier, H., Issinger, O.G., Deuschle, M. and Mundry, K.W. (1981): Translation of the RNA of cowpea severe mosaic virus in vitro and in cowpea protoplasts. 16. Reichert, G. and Issinger, O.G. (1981): Characterization of native 40S particles from Krebs II mouse ascites tumour cel s. Resolution, nomenclature, and molecular weight of the non Biochim. Biophys. Acta 654, 268-278.
15. Beier, H., Mundry, K. W., and Issinger, O. G. (1981): In vivo nd in vitro translation of the RNAs of four 14. Reichert, G., Schuck, J. and Issinger, O.G. (1981): Phosphorylation in vivo of non ribosomal proteins from native 40S ribosomal particles of Krebs II mouse ascites tumour cel s. 13. Issinger, O. G., Beier, H., Speichermann, S., Flokerzi, V., and Hofmann, F. (1980): Comparison of phosphorylation of ribosomal proteins from HeLa and Krebs II mouse ascites tumour cel s by cAMP- and Olaf-Georg Issinger: List of publications
12. Issinger, O. G. and Reichert, G. (1979): Characterization of native 40S particles from Krebs II mouse ascites tumour cel s. I. Phosphorylation in vitro of non ribosomal proteins by acAMP-independent protein Biochem. Biophys. Res. Commun. 88, 1275-1283.
11. Issinger, O. G. and Beier, H. (1978): Characterization of ribosomal proteins from HeLa and Krebs II mouse ascites tumour cel s by different two-dimensional polyacrylamide gel electrophoresis techniques. 10. Issinger, O. G. (1977): Purification and properties of a ribosomal casein kinase from rabbit reticulocytes. 9. Issinger, O.G. (1977): Phosphorylation of acidic proteins from rabbit reticulocytes by a Biochim. Biophys. Acta 477, 185-189.
8. Issinger, O. G. and Falk, H. (1976): Comparative studies of the structural proteins of T3 and T7 phages. 7. Issinger, O. G., Benne, R., Hershey, J. W. P., and Traut, R. R. (1976): Phosphorylation in vitro of eukaryotic initiation factors IF-2 and IF-3 by protein kinases. 6. Issinger, O. G., Kiefer, M. C., and Traut, R. R. (1975): Specificity of ATP-dependent and GTP-dependent protein kinases with respect to ribosomal proteins of E. coli. 5. Issinger, O. G. and Traut, R. R. (1974): Selective phosphorylation from GTP of proteins L7 and L12 of E.
coli 50S ribosomes by a protein kinase from rabbit reticulocytes. Biochem. Biophys. Res. Commun. 59, 829-836.
4. Issinger, O. G. and Hausmann, R. (1973): Synthesis of bacteriophage-coded products during infection of E. coli with amber mutants of T3 and T7 defective in gene 1.
3. Issinger, O.G., Beier, H., und Hausmann, R. (1973): In vivo and in vitro phenotypic mixing with amber mutants of phages T3 and T7 defective in gene 1.
2. Issinger, O. G., Maass, I. und Clauß, M. (1971): Photosyntheseintensität der Stielregionen von 1. Dittrich, H. H. und Issinger, O. G. (1969): Zum Wirkungsmechanismus von Dichlofluanid. Zeitschrift für Pflanzenkrankheiten 76, 651-663. Olaf-Georg Issinger: List of publications
15. Guerra, B. and Issinger, O.-G. (1998) Protein kinase CK2 and its role in cel ular proliferation and 14. Issinger, O.-G. (1993) Casein Kinases, Pleiotropic Mediators of Cel ular Regulation Pharmaceuticals and Therapeutics 59, 1-30 13. Boldyreff, B. and Issinger, O.-G. (1993) Proteinkinase und zel uläre Proliferation. 12. Boldyreff, B., Lu, Y., and Issinger, O. G. (1991): CK II, eine proliferationsassozi erte Proteinkinase beim 11. Issinger, O.-G. and Boldyreff, B. (1992) Abnormal casein kinases in: Recent Adv. in Cel. & Mol. Biol. 4, 17-22.
10. Pinna, L. A., Meggio, F., Marin, O., Perich, J. W., Boldyreff, B., and Issinger, O. G. (1992): Casein kinases: an atypical class of ubiquitous and pleiotropic protein kinases. In: Adenine Nucleotides in Cel ular Energy Transfer and Signal Transduction, eds. S. Papa, A. Azzi & J. M.
Tager, Birkhäuser Verlag, Basel, Schweiz 9. Pistorius, K., Seitz, G., Remberger, K., and Issinger, O. G. (1990): Differntial CKII activities in human colonic mucosa, polyps and carcinomas.
In: Issinger, O. G., Henke, J., Driesel, A. J. (eds.) Advances in molecular genetics, Hüthig Verlag 8. Menzel, A., Lagoda, P. J. L., and Issinger, O. G. (1990): DNA fingerprinting by a 22mer promoter-specific oligonucleotide probe containing an SP1 binding site. In: Issinger, O. G., Henke, J., Driesel, A. J. (eds.) Advances in molecular genetics, Hüthig Verlag Heidelberg, 3, 147-159 7. Boldyreff, B., Grankowski, N., Gebhard, R., and Issinger, O. G. (1990): Cloning and expression of casein In: Issinger, O. G., Henke, J., Driesel, A. J. (eds.) Advances in molecular genetics, Hüthig Verlag 6. Boldyreff, B., Schneider, H. R., Traffa, K., Fritz, G., Seitz, G., and Issinger, O. G. (1990): CKII, a pleiotropic mediator of proliferation and oncogenesis. In: Kömpf, J., Henke, J., Driesel, A. J. (eds.). Advances in molecular genetics, Hüthig Verlag Heidelberg, 2, 91-98 5. Lagoda, P. L., and Issinger, O. G. (1989): Detection of possible DNA polymorphismus in human tumour biopsy material using different minisatel ite probes. Advances in molecular genetics, Hüthig Verlag Heidelberg, 1, 115-121 4. Schneider, H. R., and Issinger, O. G. (1989): CKII, a multifunctional protein kinase and its role during 3. Issinger, O. G., and Schneider, H. R. (1989): Proliferational control in human tumours and during The Journal of Clinical Laboratory 1, 94-103 Olaf-Georg Issinger: List of publications
2. Issinger, O. G., Martin T., amd Schneider, H. R. (1989): Protein phosphorylation, a first step during The Journal of Clinical Laboratory 1, 85-93 1. Issinger, O. G., and Lagoda, P. (1989): Detection of possible DNA polymorphismus in human tumour biopsy material using different minisatel ite probes. The Journal of Clinical Laboratory 1, 53-63

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