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Rabbit Polyclonal antibody to Human PDE11A.

CPBT-56268RH Rabbit(PDE11A)
PRODUCT INFORMATION
Product Overview
Rabbit Polyclonal antibody to Human PDE11A.
Antigen Description
The 3,5-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signaltransduction pathways. 3,5-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis ofcAMP and cGMP to the corresponding 5-monophosphates and provide a mechanism to downregulatecAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutationsin this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcriptvariants encoding different isoforms have been found for this gene.
specificity
Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor inpenis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2may be expressed in testis. Isoform 4 is expressed in adrenal cortex.
Target
Immunogen
Synthetic peptide (Human) (N terminal).
Host
Isotype
species
Purification
Applications
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family.Contains 2 GAF domains.
Cellular localization
Domain
The tandem GAF domains bind cGMP, and regulate enzyme activity. The binding of cGMP leading tostimulate the enzyme activity.
PACKAGING
Format
Buffer
Stabilization buffer with 0.02% thimerosal or merthiolate.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze /thaw cycles.
ANTIGEN GENE INFORMATION
Gene Name
Official Symbol
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45-16 Ramsey Road Shirley, NY 11967, USA Synonyms
PDE11A; phosphodiesterase 11A; dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A; 5-cyclic-AMP and -GMP phosphodiesterase 11A; cAMP and cGMP cyclic nucleotide phosphodiesterase 11A;cAMP and cGMP phosphodiesterase 11A; cAMP phosphodiesterase 11A; cGMP phosphodiesterase11A; Cyclic nucleotide phosphodiesterase 11A; Cyclic nucleotide phosphodiesterase 11A1; Dual 3 5cyclic AMP and GMP phosphodiesterase 11A; Dual 3; Dual 3,5-cyclic-AMP and -GMPphosphodiesterase 11A; FLJ23693; MGC133355; MGC133356; PDE 11A; pde11; PDE11_HUMAN;PDE11A; PDE11A1; pde11a2; Phosphodiesterase 11A; PPNAD2; OTTHUMP00000205269;OTTHUMP00000205270; OTTHUMP00000205271; OTTHUMP00000205272;OTTHUMP00000205273; cAMP and cGMP phosphodiesterase 11A; cyclic nucleotidephosphodiesterase 11A; cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; PPNAD2; GeneID
mRNA Refseq
Protein Refseq
MIM
UniProt ID
Chromosome Location 2q31.3
Pathway
G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Hemostasis, organism-specific biosystem; Nitric oxide stimulates guanylatecyclase, organism-specific biosystem; Platelet homeostasis, organism-specific biosystem; Purinemetabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; Function
3,5-cyclic-GMP phosphodiesterase activity; 3,5-cyclic-nucleotide phosphodiesterase activity; cAMPbinding; cGMP binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; REFERENCES
1. Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1Amutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype. Libé R, et al. J ClinEndocrinol Metab, 2011 Jan.
2. PDE11A associations with asthma: results of a genome-wide association scan. DeWan AT, et al. J Allergy Clin Immunol, 2010Oct.
3. Phosphodiesterase 11A (PDE11A) genetic variants may increase susceptibility to prostatic cancer. Faucz FR, et al. J ClinEndocrinol Metab, 2011 Jan.
Creative BioMart. All rights reserved
45-16 Ramsey Road Shirley, NY 11967, USA

Source: http://img.creativebiomart.net/pdf/CPBT-56268RH,PDE11A.pdf

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