Safety data sheet

SIGMA-ALDRICH
sigma-aldrich.com
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product identifiers
Product name
Relevant identified uses of the substance or mixture and uses advised against
: Laboratory chemicals, Manufacture of substances Details of the supplier of the safety data sheet
1 Science Park Road #02-14 The Capricorn Singapore Science Park Road II SINGAPORE 117528 SINGAPORE Emergency telephone number
HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Reproductive toxicity (Category 1B)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
May cause harm to the unborn child.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
May damage fertility or the unborn child. IF exposed or concerned: Get medical advice/ attention.
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
Sigma - F4381
Avoid exposure - obtain special instructions before use. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Other hazards - none
COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Synonyms
: 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid Furosemide
FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Indication of any immediate medical attention and special treatment needed
no data available
FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx), Sulphur oxides, Hydrogen chloride gas
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Sigma - F4381
Further information
no data available
ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure
adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.
HANDLING AND STORAGE
Precautions for safe handling
Avoid formation of dust and aerosols.Avoid exposure - obtain special instructions before use.
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Specific end uses
no data available
EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested
and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Body Protection
impervious clothing, The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face particle
respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering
controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use
respirators and components tested and approved under appropriate government standards such
as NIOSH (US) or CEN (EU).
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PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
Flammability (solid, gas) no data available Other safety information
no data available
STABILITY AND REACTIVITY
10.1 Reactivity
10.2 Chemical stability
10.3 Possibility of hazardous reactions
10.4 Conditions to avoid
10.5 Incompatible materials
10.6 Hazardous decomposition products
Other decomposition products - no data available Sigma - F4381
TOXICOLOGICAL INFORMATION
11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - rat - 2.600 mg/kg
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC, ACGIH, NTP, or EPA classification. 3 - Group 3: Not classifiable as to its carcinogenicity to humans (Furosemide) Reproductive toxicity
May cause congenital malformation in the fetus.
Presumed human reproductive toxicant
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation
May be harmful if inhaled. May cause respiratory tract irritation. Ingestion
May be harmful if absorbed through skin. May cause skin irritation. Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Additional Information
RTECS: CB2625000
ECOLOGICAL INFORMATION
12.1 Toxicity
12.2 Persistence and degradability
12.3 Bioaccumulative potential
12.4 Mobility in soil
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12.5 Results of PBT and vPvB assessment
12.6 Other adverse effects
DISPOSAL CONSIDERATIONS
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
professional waste disposal service to dispose of this material. Dissolve or mix the material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.
TRANSPORT INFORMATION
14.1 UN number
14.2 UN proper shipping name
14.3 Transport hazard class(es)
14.4 Packaging group
14.5 Environmental hazards
14.6 Special precautions for user
REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
15.2 Chemical Safety Assessment
OTHER INFORMATION
Further information
Copyright 2012 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held
liable for any damage resulting from handling or from contact with the above product. See www.sigma-
aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.
Sigma - F4381

Source: http://chem.pharmacy.psu.ac.th/chemical/msds/furosemide.pdf