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Drugs responsible for acute interstitial nephritis (AIN)
Antimicrobial agents:
Acyclovir, AMPICILLINab, Amoxicillin, Aztreonam, Carbenicillin, Cefaclor, Cefamandole, Cefazolin, Cephalexin, Cephaloridine, Cephalothin, Cephapirin, Cephradine, Cefixitin, Cefotetan, Cefotaxime, CIPROFLOXACIN, Cloxacillin, Colistin, Cotrimoxazoleb, Erythromycin, Ethambutol, Foscarnet, Gentamicin, Indinavir, Interferon, Isoniazid, Lincomycin, METHICILLINb, Mezlocillin, Minocycline, Nafcillin, Nitrofurantoinb, Norfloxacin, Oxacillinb PENICILLIN Gb, Piperacillin, Piromidic acid, Polymyxin acidb , Quinine, RIFAMPICINb , Spiramycineb , SULFONAMIDES, Teicoplanin, Tetracycline, Vancomycin NSAIDs including salicylates
Alclofenac, Azapropazone, ASPIRIN, Benoxaprofen, Diclofenac, Diffunisalb ,
Fenclofenac, FENOPROFEN, Flurbiprofen, IBUPROFEN, INDOMETHACIN,
Ketoprofen, Mefenamic acid, Meloxicam, MesaIazine (5-ASA), NAPROXEN,
Niflumic acid, Phenazone, PHENYLBUTAZONE, PIROXICAM, Pirprofen,
Sulfasalazine, Sulindac, Suprofen, TOLEMETIN, ZOMEPIRAC
Analgesics
Aminopyrine, Antipyrine, Antrafenin, Clometacinb, Floctafeninb , Glafeninb , Metamizol, Noramidopyrin Anticonvulsants
Carbamazepine, Diazepam, Phenobarbital, PHENYTOINb , Valproate sodium Diuretics
Indapamide, Tienilic acidb , Triamtereneb ALLOPURINOLb , Alpha-methyldopa, Azathioprine, Bethanidine, Bismuth salts, Captoprilb, Carbimazoleb, Chlorpropamide, Cyclosporine, CIMETIDINE, Clofibrate, Clozapine, Cyamethazineb, D-penicillamine, Fenofibrateb , Gold salts, Griseofulvin, Interferon, Interleukin-2, OMEPRAZOLE, PHENINDIONEb, Phenothiazine, Phenylpropanolamine, Probenecid, Propranolol, Propylthiouracil, Ranitidine, Streptokinase, Sulphinpyrazone, Warfarin a Drugs most commonly involved are shown in capitalletters b Drugs that can induce granulomatous AIN
BIBLIOGRAFIA
1. Kodner CM, Kudrimoti A. Diagnosis and Management of Acute Interstitial Nephritis.
American Family Physician 2003; 12: 2527-2534
2. Choudhury D, Ahmed Z. Drug-associated renal dysfunction and injury. Nature Clinical

3. Rossert J. Drug-induced acute interstitial nephritis. Kidney International 2001; 60: 804-817
4. Michielsen P. In memoriam “analgesic nephropathy“ (circa 1972-2006). Nephrology
Dialysis Transplantation 2007; 22: 999-1001
5. Reece RJ, Nicholls AJ. Ciprofloxacin-induced acute interstitial nephritis. Nephrology
Dialysis Transplantation 1996; 11(2)2: 393
6. Gauffre A et al. Autoantibodies against a kidney-liver protein associated with quinolone-
induced acute interstitial nephritis or hepatitis. Nephrology Dialysis Transplantation 1997;
12: 1961-1962

7. Hung Chi-Chih et al. Fluoroquinolone-induced acute interstitial nephritis in
immunocompromised patients: two case reports. Nephrology Dialysis Transplantation 2006;
21: 237-238

8. Solomon R. Contrast media nephropathy – how to diagnose and to prevent? Nephrology
Dialysis Transplantation 2007; 22: 1812-1815
9. McWilliam LJ. Drug-induced renal disease. Current Diagnostic Pathology 2007; 1: 25-31
10. Markowitz GS, Perazella MA. Drug-induced renal failure: a focus on tubulointerstitial
nephritis. Clinica Chimica Acta 2005; 351: 31-47

11. Baker RJ, Pusey CD. The changing profile of acute tubulointerstitial nephritis. Nephrology

12. Kelly JC, Neilson EG. Tubulointerstitial Diseases. In: The Kidney (Brenner & Rector’s) 2004;

13. Rose BD, Appel GB. Clinical manifestations and diagnosis of acute interstitial nephritis.

14. Kshirsagar AV, Falk RJ. Treatment of acute interstitial nephritis. UpToDate.com 15.9.2006
15. Lee G. Ashfaq A. Tubulointerstitial nephritis and uveitis (TINU syndrome). UpToDate.com

16. De Broe ME. Analgesic nephropathy. UpToDate.com 27.11.2007

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