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Separation and Quantitation of R and SEnantiomers using Normal PhaseChromatography on an API 3000™LC/MS/MS System
Normal phase chromatography can
strates that it is possible to safely and
be used for the analysis of chiral
compounds using the API 3000™
Figure 1. Verapamil calibration curves for enantiomer R and S.
Figure 2. Methylphenidate calibration curves for enantiomer R and S.
APCI (Nitrogen gas used for all connections)
animals dosed with racemic mixtures.
the coronary vasodilator, verapamil.
Figure 3. Fluoxetine calibration curves for enantiomer R and S.
Figure 4. Verapamil, 0.1 ng/mL racemate concentration, extracted from
Figure 5. Methylphenidate, 0.1 ng/mL racemate concentration,
extracted from rat plasma.
Results and Discussion
centration range of 0–1,000 ng/mL.
separation, approximately 65 minutes.
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Figure 6. Fluoxetine, 100 ng/mL racemate concentration, extracted from rat
plasma and fluoxetine, 10 ng/mL racemate concentration, extracted from rat
plasma plus integrating a switching valve to overcome mobile phase incom-
patibility. Note that the intensity is comparable despite the ten-fold
decrease in analyte concentration.
Not for use in diagnostic procedures.
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Printed in the USA, 12/2000, BHLPublication 114AP12-01
British Journal of Haematology, 2002, 117, 768–774PROLONGED COMPLETE REMISSION IN TWO CASES OF ACUTE PROMYELOCYTIC LEUKAEMIATREATED WITH ATRA ALONEThe use of all-trans retinoic acid (ATRA) therapy forplatelet count was normal. On day 58, bone marrowinduction for acute promyelocytic leukaemia (APL) is wellshowed morphological remission, with normal cytogeneticsestablished and leads to a com
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