CV of Zhiren Zhang Curriculum Vitae Personal information Birthday Nationality Telephone Education 09/1993 - 06/1998
Tongji Medical University, Wuhan, P.R. China.
Certificate: Bachelor Degree of Medicine 09/1998 - 06/2001
Tongji Medical School, Huazhong University of Science and
Certificate: Master Degree of Medicine 09/2001 - 06/2004
Tongji Medical School, Huazhong University of Science and
Certificate: PhD Degree of Biochemistry and Molecular 10/2002 - 06/2004
Institute of Brain Research, Tuebingen University, Tuebingen,
Guest student 07/2004 - 07/2006
Institute of Brain Research, Tuebingen University, Tuebingen,
Certificate: Dr. sc. hum.
10/2002 - 02/2006
Scholar in the Graduate College of " Cell Biological
Mechanisms of Immune-associated Processes", Graduate
CV of Zhiren Zhang Working experiences 08/2006 - 12/2009 Research Scientist
Institute of Brain Research, Tuebingen University, Tuebingen,
1/2010 - till now Professor
Institute of Immunology, Third Military Medical University of
Research interest: macrophage polarization, traumatic brain injury, EAN, EAE Current project:
Effects of M2 macrophages on the self-recovery of EAN (National Natural Science
Functional macrophage polarization in brain following traumatic brain injury (Natural
Science Foundation Project of CQ CSTC, No. 2010BB5025).
Epigenetic regulation of functional macrophage polarization (Intramural project of
Third Military Medical University of PLA ).
Honours and scholarship
Chinese Government Award for Outstanding Self-financed
09/2002-02/2004 Scholarship for a Ph.D. student within the Graduate College of
"Cell Biological Mechanisms of Immune-associated Processes"
CV of Zhiren Zhang List of publications
Zhang ZY, Zhang Z, Schluesener HJ. 2010. MS-275, an histone deacetylase
inhibitor, reduces the inflammatory reaction in rat experimental autoimmune
neuritis. Neuroscience. 169, 370-377.
Zhang Z., Zhang Z.Y., and Schluesener H.J. 2009. Compound A, a plant origin
ligand of glucocorticoid receptor, increases regulatory T cells and M2-type
macrophages to attenuate experimental autoimmune neuritis with reduced side
effects. The Journal of Immunology. 183, 3081-3091.
Zhang Z.Y., Zhang Z., Fauser U., and Schluesener H.J. 2009. Improved
outcome of EAN, an animal model of GBS, through amelioration of peripheral
and central inflammation by minocycline. Journal of Cellular and Molecular
Zhang Z.Y., Zhang Z., Fauser U., and Schluesener H.J. 2009. Expression of
interleukin-16 in sciatic nerves, spinal roots and spinal cords of experimental
autoimmune neuritis rats. Brain Pathology. 19, 205-213.
Zhang Z., Zhang Z.Y., Fauser U., and Schluesener H.J. 2009. Distribution of
Foxp3+ T-regulatory cells in experimental autoimmune neuritis rats.
Experimental Neurology. 216, 75-82.
Zhang Z.Y., Zhang Z., and Schluesener H.J. 2009. Toll-like receptor-2, CD14
and heat-shock protein 70 in inflammatory lesions of rat experimental
autoimmune neuritis. Neuroscience. 159, 136-142.
Zhang Z.Y., Zhang Z., Artelt M., Burnet M., and Schluesene H.J. 2009.
FTY720 influences interleukin-17+ cell localization in experimental
autoimmune neuritis rats. Neuropathology and Applied Neurobiology. 159, 136-
CV of Zhiren Zhang
Li X.B., Zheng H., Zhang Z., Li M., Huang Z.Y., Schluesener H.J., Xu S.Q.
2009. Peripheral administration of nano-scale aluminium oxide induces glia
activation in rat brains. Nanomedicine-Nanatechnology Biology and Medicine.
Li X.B., Zheng H., Zhang Z., Li M., Huang Z.Y., Schluesener H.J., Xu S.Q.
2009. Apoptosis induced by titanium dioxide nanoparticles in cultured murine
microglia N9 cells. Chinese Science Bulletin. 54, 3830-3836.
Zhang Z., Zhang Z.Y., and Schluesener H.J. 2008. Oligodeoxynucleotide
uptake in primary rat and human hematopoietic cells is different. Cellular and Molecular Life Science. 65, 1237-1247.
Zhang Z., Zhang Z.Y., Fauser U., and Schluesener H.J. 2008. Valproic acid
attenuates inflammation in experimental autoimmune neuritis. Cellular and Molecular Life Science. 65, 4055-4065.
Zhang Z., Zhang Z.Y., Fauser U., and Schluesener H.J. 2008. Mechanical
allodynia and spinal up-regulation of P2X4 receptor in experimental
autoimmune neuritis rats. Neuroscience. 152, 495-501.
Zhang Z., Zhang Z.Y., and Schluesener H.J. 2008. FTY720 ameliorates
Experimental Autoimmune Neuritis by inhibition of lymphocyte and monocyte
infiltration to peripheral nerves. Experimental Neurology. 210, 681-690.
Zhang Z., Artelt M., Burnet M., Fauser U., Schluesener H.J. 2008.
Dexamethasone Suppresses Infiltration of RhoA+ Cells into Early Lesions of Rat
Traumatic Brain Injury. Acta Neuropathology (Berl). 115, 335-343.
Zhang Z., Schittenhelm J., Meyermann R., Schluesener H.J. 2008. Lesional
expression of RhoA in brains of experimental autoimmune encephalomyelitis
and multiple sclerosis. Neuropathology and Applied Neurobiology. 34, 231-240.
CV of Zhiren Zhang Zhang Z., Fauser U., Schluesener H.J. 2008. Early Attenuation of Lesional
Interleukin-16 Up-regulation by Dexamethasone and FTY720 in Experimental
Traumatic Brain Injury. Neuropathology and Applied Neurobiology. 34, 330-
Zhang Z., Fauser U., Schluesener H.J. 2007. Expression of RhoA by
inflammatory macrophages and T cells in rat experimental autoimmune neuritis.
Journal of Cellular and Molecular Medicine. 11, 111-119.
Zhang Z.Y., Zhang Z., Artelt M., Burnet M., and Schluesene H.J. 2007.
Dexamethasone attenuates early expression of molecules associated with
microglia/macrophages activation following rat traumatic brain injury. Acta Neuropathology (Berl). 113, 675-678. (Equal first author).
Zhang Z. and Schluesener H.J. 2007. FTY720: a most promising
immunosuppressant modulating immune cell functions. Mini Reviews in
Zhang Z.Y., Zhang Z., Artelt M., Burnet M., and Schluesene H.J. 2007.
macrophages/microglia in early lesions of rat traumatic brain injury. Journal of Cellular and Molecular Medicine. 11, 307-314.
Zhang Z.Y., Zhang Z., Fauser U., Artelt M., Burnet M., Fauser U., Schluesener
H.J. 2007. Early but Transient Attenuation of Lesional Accumulated
Endostatin/Collagen XVIII+ Microglia/Macrophages by Dexamethasone in
Experimental Traumatic Brain Injury. Neuroscience. 147, 720-726.
Yang Y., Yang D.L., Schluesener H.J., Zhang Z. 2007. Advances in SELEX
And Application of Aptamers in The Central Nervous System. Biomolecular
Zhang Z.Y., Zhang Z., Fauser U., Artelt M., Burnet M., Fauser U., Schluesener
HJ. 2007. Injury-induced Hypomethylation Defines a Sub-population of
CV of Zhiren Zhang
Reactive Microglia/Macrophages in Experimental Traumatic Brain Injury.
Zhang Z., Artelt M., Burnet M., Trautman K., and Schluesene H.J. 2006.
Lesional accumulation of P2X4 receptor+ monocytes after experimental brain
injury. Experimental Neurology. 197, 252-257.
Zhang Z., Trautman K., Artelt M., Burnet M., and Schluesene H.J. 2006. Bone
morphogenetic protein-6 up-expression in early-activated astrocytes following
traumatic brain injury. Neuroscience. 138, 47-53.
Zhang Z., Weinschenk T. and Schluesener H.J. 2006. siRNA binding proteins
of microglial cells: PKR is an unanticipated ligand. Journal of Cellular Zhang Z., Trautman K., Artelt M. and Schluesene H.J. 2006. Early infiltration
of CD8+ microglia/macrophages to lesion locates following traumatic brain
injury. Neuroscience. 141, 627-644.
Li XB, Zhang Z, Schluesener HJ, Xu SQ. 2006. Exosome and its applications in
tumor immunotherapy. Journal of Cellular and Molecular Medicine. 10, 364-
Zhang Z., Fauser U., Trautmann K., Schluesener HJ. 2006. PolyG motif
increases cellular oligonucleotide uptake in brain cortex. Neuroreport. 17, 1579-
Zhang Z., Schittenhelm J., Guo K., Buhring H.J., Trautmann K., Meyermann R.,
and Schluesener H.J. 2006. Frizzled 9 (FZD9) is upregulated in human
astrocytomas. Neuropathology and Applied Neurobiology. 32, 615-624.
Zhang Z., Schluesener HJ. 2006. Mammalian toll-like receptors: A new bridge
from innate immunity to tissue regeneration, Cellular and Molecular Life CV of Zhiren Zhang
Su Y.H., Zhang Z., Trautman K. and Schluesener H.J. 2005. TLR and NOD2
ligands induce cell proliferation in the rat intact spinal cord. Journal of Neuropathology and Experimental Neurology 64, 991-997. Zhang Z., Trautman K. and Schluesener H.J. 2005. Microglia activation in rat
spinal cord by systemic injection of TLR 3 and TLR7/8 agonists. Journal of Zhang Z., Trautman K. and Schluesener H.J. 2005. Repeated ip injection of
poly (I:C) activates spinal cord microglia and astrocyte in rat. Neuroreport 16,
Zhang Z., Guo K.T. and Schluesener H.J. 2005. The immunostimulatory
activity of CpG-oligonucleotides on microglia cells is affected by polyguanosine
motif. Journal of Neuroimmunology 161, 68-77.
Zhang Z., Weinschenk T. and Schluesener H.J. 2005. Uptake, Intracellular
Oligodeoxynucleotides in Microglial Cells. Journal of Neuroimmunology 160,
Zhang Z. and Schluesener H.J. 2005. Protein pigpen is one of the cellular
binding proteins of therapeutic oligonucleotides. Cytotherapy 7, 186-194.
Zhang Z., Weinschenk T. and Schluesener H.J. 2005. Uptake, Intracellular
Oligodeoxynucleotides in Glioblastom Cells. Molecular and Cellular
Li X., Zhang Z., Beiter T., Schluesener H.J. 2005. Nanovesicular vaccines:
exosomes. Arch Immunol Ther Exp (Warsz). 53, 329-335.
Zhang Z., Blank M. and Schluesener H.J. 2004. Nucleic Acid Aptamers in
Human Viral Disease. Arch. Immunol. Ther. Exp. (Warsz). 52, 307-315.
CV of Zhiren Zhang Zhang Z., Xu S.Q., et al. 2003. Characteristics and application of established
luciferase hepatoma cell line that responds to dioxin-like chemicals. World Journal of Gastroenterology. 9, 1460-1464.
Zhang Z., Xu S.Q., et al. 2002. Improvement of chemically-activated luciferase
gene expression bioassay for detection of dioxin-like chemicals. Biomedical Environmental Science. 15, 58-66.
Xu S.Q., He M., Yu H.P., Wang X.Y., Tan X.L., Lu B., Sun X., Zhou Y.K., Yao
Q.F., Xu Y.J., Zhang Z.R. 2002. Bioluminescent Method for Detecting
Telomerase Activity. Clinical Chemistry. 48, 1016-1020.
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