FRIDAY, OCTOBER 11 Auditorium César Roux
07:30 Opening Ceremony
Prof. P. F. Leyvraz (Orthopedic Hospital, Lausanne)
07:40 Bioengineering at the Swiss Federal Institute of Technology
Prof. S. Catsicas (Vice-President, EPF-Lausanne)
08:00 Keynote Lecture: State of the art and perspective in total joint replacement FRIDAY, OCTOBER 11 Auditorium César Roux Auditorium Auguste Tissot 1a: Implant clinical studies 2a: Cartilage biology
09:00 Assessment of the impact of underly- Knee cartilage of spinal cord injured patients ing joint disease on the pathogenesis of displays progressive thinning in the absence of osteolysis and aseptic loosening of joint normal joint loading and movement prostheses
09:15 In vivo determination of knee kine- Mechanical loading modulates the sulfation matics for subjects implanted with a pattern of chondroitin sulfate from articular unicompartmental arthroplasty cartilage explants
K. Sauerland, A. H. K. Plaas, R.X. Raiss,
09:30 Detection of hip stem loosening by Early osteoarthritic changes of the femoral vibration analysis: a per-operative head cartilage subsequent to femoro-acetabu- case study lar impingement
09:45 Isoprostanes in monitoring the oxida- Enhanced expression of the human chitinase tive stressing patients following the 3-like 2 gene (chi3l2, ykl-39) in osteoarthritic total joint replacement cartilage
10:00 Cup inclination and serum metal levels Differential induction and regulation of in THA with metal-on-metal bearing matrix metalloproteinases in osteoarthritic tissue and fluid synoviocytes
B. Dankbar, A. Skwara, M. Bloch,W. Winkelmann, S. Fuchs
10:15 Surface analysis of early retrieved CD44H and the isoforms CD44v5 and acetabular polyethylene liners: a com- CD44v6 in the synovial fluid of the parison of conventional and highly osteoarthritic human knee joint crosslinked polyethylenes
S. Fuchs, B. Rolauffs, S. Arndt, C. O. Tibesku,
C. Bragdon, M. Jasty, A. Freiberg,D. Burke, W. Harris
Coffee Break FRIDAY, OCTOBER 11 Auditorium César Roux Auditorium Auguste Tissot 1b: Implant biomechanics 2b: Bone biology
11:00 The protective role of metal-on-metal Thermal stress and the heat shock response in bearing against dislocation after total osteoblasts and marrow stromal cells hip replacement
M. Hafez, O. Emohare, A. Sandison, J. Batten,
11:15 The in-vitro failure behavior of a novel Pulsed electromagnetic fields affect local fac- metaphyseal cemented hip prosthesis tor production and connexin 43 protein expression in mlo-y4 osteocyte-like cells and ros 17/2.8 osteoblast-like cells C. H. Lohmann, Z. Schwartz, Y. Liu, Z. Li, B. J. Simon, V. L. Sylvia, D. D. Dean, L. Bonewald, H. J. Donahue, B. D. Boyan
11:30 Simulation of systemic alendronate The effects of glutamate antagonists on bone treatment following a THA cell growth in vitro
11:45 Evolution of the biomechanical Stimulatory effects of creatine on metabolic strength of a skeletal reconstruction in activity, differentiation and mineralization of paediatric oncology using the finite ele- primary rat osteoblast-like cells in monolayer ment method: preliminary results and micromass cell culture
I. Gerber, I. A. Gwynn, M. Alini, T. Wallimann
12:00 Successful finite-element-based pre- Influence of extracorporeal shock wave appli- clinical testing of cemented THA stems cation on normal bone in an in-vivo animal trial - scintigraphic, magnetic resonance imaging and histopathological evaluations T. Tischer, S. Milz, C. Schmitz, M. Maier
12:15 Thermal bone necrosis at the bone- Analysis of growth, angiogenesis and micro- cement interface after cemented THA: circulation of primary and secondary bone a finite element analysis tumors: an experimental study in mice
F. Klenke, T. Merkle, M. M. Gebhard,V. Ewerbeck, A. Sckell
Boni Award Lecture (Auditorium César Roux) FRIDAY, OCTOBER 11 Keynote Lecture (Auditorium César Roux) Biofunctional surfaces trends in chemical and topographic patterning of surfaces to steer their biological response Auditorium César Roux Auditorium Auguste Tissot 3: Implant interface 4: Soft tissue biology
15:00 Micromechanics of the bone-implant- Distinct Expression of APO-1 and Caspase-8 interface measured by scanning in the human growth plate acoustic microscopy
E. Cetin, W. Girsch, G. Brand, E. M. Cetin,
15:15 Response of human macrophages to New in vivo animal model to create interverte- challenge with polyethylene wear bral disc degeneration and to investigate debris harvested during revision effects of therapeutic strategies to stimulate arthroplasty disc regeneration
M. Kroeber, F. Unglaub, H. Wang, C. Schmid,W. Richter, V. Ewerbeck
15:30 Numerical model of the fibrous tissue Activation of MMP-2 in intervertebral discs formation around implants during static loading
P. Büchler, D. Pioletti, L. Rakotomanana
15:45 Rinsing morselized allografts pH and inflammatory mediators modulate improves bone and tissue ingrowth nucleus pulposus cytokine secretion
P. Moroney, R.W. Watson, J. Burke, J. O'Byrne,
16:00 In vitro stability of distal femoral plugs Oral vitamin C reduces compartment syn- during cementation drome induced skeletal muscle injury
S. Kearns, C. Condron, D. Bouchier-Hayes,
16:15 How close does an uncemented hip Freeze-substitution shows that knee ligaments stem match the final rasp position? are tubular structures
Y. Gijssen, J. van Marle, R. van Noorden,
Poster session (Wine & Cheese) SATURDAY, OCTOBER 12 Keynote Lecture (Auditorium César Roux) Skeletal tissue engineering Auditorium César Roux Auditorium Auguste Tissot 5a: Tissue engineering 1 6a: Bone biomechanics
09:00 Tissue engineering strategies for inter- Investigation of bovine bone by resonant vertebral disc repair ultrasound spectroscopy
09:15 Efficient and uniform cell seeding of 3- Assessment of bone quality after experimental D scaffolds with a perfusion bioreactor limb allotransplantation
09:30 Characterization of fetal skeletal mus- Biomechanical and orally administrated bis- cle for tissue engineering phosphonate effects on bone remodeling: a theoretical approach
09:45 Prostaglandins modulate the rediffer- Macromolecular movement through cortical entiation of monolayer-expanded adult bone measured by quantitative fluorescence human articular chondrocytes microscopy: bone as a chemical engineering structure
G. Johnson-Ogubneke, I. D. McCarthy,C. P. Winlove, S. P. F. Hughes, A. Sandison,M. I. Hafez, E. R. Draper, J. Batten
10:00 Self-assembling peptide scaffold for Effects of low intensity pulsed ultrasound on cartilage tissue engineering: effects of fluid displacements in bone. First results using cyclic compression and culture condi- a novel 'ex vivo' model
10:15 Replacement of the knee meniscus by The influence of vertebral endplate porosity biodegradable porous polymer pros- on the compressive creep behaviour of inter- theses. A study in dogs vertebral discs
R. Heijkants, J. H. de Groot,A. J. Schouten, R. Veth
Coffee break SATURDAY, OCTOBER 12 Auditorium César Roux Auditorium Auguste Tissot 5b: Tissue engineering 2 6b: Soft tissue biomechanics
11:00 Cartilage-like gene expression in dif- High intensity focussed ultrasound heating of ferentiated human stem cell spheroids the intervertebral disc
J. Persson, I. Mårtenson, I.D. McCarthy,
11:15 Can the type and method of produc- Real-time imaging of solute transport in tion of collagen scaffolds influence the dynamically compressed cartilage quality of bio-engineered cartilage?
A. Gigante, C. Bevilacqua, A. Ricevuto,M. Marinelli, F. Greco
11:30 Addition of transforming growth fac- Effects of stress shielding on the biomechani- tor beta1 to a ceramic bone substitue cal properties of healing tissues in the patellar and its effect on bone formation in a tendon partially resected its central third model of revision arthroplasty
K. Hayashi, T. Hiro, Y. Kitamura, H. Tohyama,
11:45 Osteogenic properties of porous grad- Acute mechanical injury of cartilage: com- ed hydroxyapatite loaded with TGF-β parison with a fibril reinforced poroelastic finite element model EORS General Assembly (Auditorium César Roux) SATURDAY, OCTOBER 12 Keynote Lecture (Auditorium César Roux) Computer assisted orthopaedic surgery - basic concepts Auditorium César Roux Auditorium Auguste Tissot 7a: Biomaterials 8a: Fracture
15:00 A comparative study of the in vivo Effect of interfragmentary shear vs. compres- behaviour in rabbits of carbonate-sub- sion on the early phase of fracture healing stituted, silicate-substituted and phase
I. Tami, N. Bishop, E. Schneider, P. Regazzoni,
pure hydroxyapatite ceramics
N. Patel, S. Best, I. Gibson, K. Hing,P. Revell, W. Bonfield
15:15 Fracture toughness of novel bone Spatial distribution of bone blood flow in the cement containing triphenyl bismuth rabbit tibia after distraction osteogenesis
H. Eckardt, K. S. Christensen, M. Lind,E. S Hansen, I. Hvid
15:30 Degradation behaviour of hydroxyap- Subcapital neck of femur fracture fixation. A atite reinforced polylactides biomechanical study using synthetic femora
N. Theilgaard, N. Svensen, Y. Gauthier,R. Martinetti
15:45 Viscosupplementation of osteoarthritic A bio-mechanical study of dynamic compres- joints with a novel synthetic lubricant sion plate, limited contact dynamic compres- sion plate and the fixclips R. Vadivelu, A. Baker, T. Miles, J. Cunningham, D. Chetwynd
16:00 Influence of counterface roughness on Exchange of ilizarov external fixaton by the wear behaviour of two types of intramedullary nail, during callus consolida- UHMWPE measured on two inde- tion phase of limb lengthening. An experimen- pendent screening pin-on-disc devices tal sheep model
E. Sourgiadaki, A. Panagopoulos, M. Tyllianakis
16:15 Micro-raman study on ETO and Extravasation risk factors in bone augmenta- gamma sterilised UHMWPE acetabu- lar cups worn on a hip joint simulator
M. Bohner, G. Bigolin, B. Gasser, G. Baroud,
in the presence of third-body PMMA debris S. Affatato, G. Bersaglia, P. Taddei, A. Tinti, C. Fagnano, A. Toni Coffee break SATURDAY, OCTOBER 12 Auditorium César Roux Auditorium Auguste Tissot 7b: Implant 8b: Joint biomechanics
17:00 Validation of the use of digital radiog- Vertebral endplate marrow contact channel raphy for radiostereometric analysis of occlusions: a mechanism for intervertebral THR wear and an evaluation of two disc degeneration? RSA software systems using a phan-
L. Benneker, S. Anderson, P. Heini, M. Alini,
tom model
C. Bragdon, D. Estok, J. Veldhoven,X. Yuan, R. Bourne, H. Malchau,J. Kärrholm, W. Harris
17:15 Analysis of early retrieved acetabular A finite element model of the L5-S1 functional cups of hoghly crosslinked polyethyl- spinal unit: development and comparison with biomechanical tests in vitro
17:30 Per-operative evaluation of the place- Bi- and unipedicular cement augmentation in ment of the souter-strathclyde elbow an osteoporotic functional spinal unit: finite prosthesis element analyses
17:45 Does combined anterior and posterior Effect of ACL graft tension on anterior and spinal fixation confer advantages over rotatory stability posterior alone?
A. Jones, D. Dillon, S. Evans, C. Holt,J. Howes, P. Davies
18:00 The importance of the endplate for Prosthetic replacement of the medial menis- intervertebral cages in the lumbar cus in human cadaver knees; does the prosthe- spine: finite element analyses sis mimic the functional behavior of the native
A. Polikeit, S. J. Ferguson, L. P. Nolte,
meniscus?
T. van Tienen, R. Heijkants, P. Buma,A. van Kampen, R. Veth, N. Verdonschot
18:15 Initial stability of ankle arthrodesis Anatomy and biomechanics of the posterior with internal fixation. Finite element transosseous capsulotendinous repair in total comparison of two methods of joint hip arthroplasty: a cadaver study. surface preparation. EORS Banquet, Boni + Selvik + Poster Awards (Le Montagnard) SUNDAY, OCTOBER 13 Keynote Lecture (Auditorium César Roux) Skeletal imaging: of mice and men Auditorium César Roux Auditorium Auguste Tissot 9a: Imaging and trabecular architecture 10a: Clinical studies 1
09:00 Mechanism of age-related changes in The UK national joint registry: where did it three-dimensional microarchitecture come from and where is it going? of bone and cartilage tissues in guinea pig spontaneous osteoarthrosis M. Ding, I. Hvid
09:15 Mechanical consequences of different Cemented versus cementless stem-to-bone fix- scenarios for simulated bone atrophy ation: a long term survival comparison with and recovery in the distal radius an identical prosthetic design and ceramic on ceramic coupling
A. Toni, F. Traina, B. Bordini, S. Stea,S. Paderni, A. Giunti
09:30 Micro-computer tomography scan- Multivariate analysis of factors predisposing ning of cortical bone development to dislocation after primary total hip arthro-
09:45 Trabecular level strain measurements The effect of traction on compartment pres- by means of a 3D image correlation sures during intramedullary nailing of tibial shaft fractures. A randomised prospective
S. Kutty, A. Laing, C.V. R. Prasad, J. P McCabe
10:00 Element based morphometric charac- Colles' fracture and subsequent hip-fracture terization of trabecular bone risk in men: a meta-analysis
P. Haentjens, P. Autier, J. Collins, B. Velkeniers,D. Vanderschueren, S. Boonen
10:15 The contribution of trabecular orien- Circulating levels of interleukin-6 and its solu- tation on the fixation of cancellous ble receptor in patients with head injury and bone screws fracture
C. Beeton, D. Chatfield, R. Brooks, N. Rushton
Coffee break SUNDAY, OCTOBER 13 Auditorium César Roux Auditorium Auguste Tissot 9b: Surgical techniques 10b: Clinical studies 2
11:00 Incorporation of a novel 3D fluoro- Salvage of RSA compromised by insufficient scope in surgical navigation
X. Yuan, J. Patel, R. McCalden, S. MacDonald,
11:15 Intraoperative assessment of the pri- Joint and segment angles of lower limbs in hip mary stability of cementless hip stems osteoarthitis and total hip replaced patients
L. Cristofolini, I. Pelgreffi, A. Cappello,
measured using physilog system
H. Dejnabadi, K. Aminian, B. Najafi,C. Trevisan, A. Telonio, C. Frigo, E. Pavah,E. C. Marinoni, Ph. Robert, P. F. Leyvraz
11:30 Force control for registration and Single limb stance adduction moment in medi- bone-machining in robot-assisted total al compartment osteoarthritis of the knee knee arthroplasty
W. Y. J. Kim, J. Richards, R. Chandru, A. Hegab
K. Denis, J. Bellemans, G. Van Ham,J. Vander Sloten, G. Fabry,J. De Schutter, R. Van Auderkercke,G. Van der Perre
11:45 C-arm based 3D-navigation in pedicle Variation in the orientation of the rotation screw and si-screw placement: experi- axis during elbow flexion mental evaluation and first clinical
A. Ericson, A. Arndt, A. Stark, P. Wretenberg,
E. Euler, S. M. Heining, C. Riquarts,W. Mutschler
Closing ceremony (Auditorium César Roux) EORS POSTER EXHIBIT Implant clinical studies Implant interface A novel stem design for anchorage of tumour Osseointegration of tetrapodic macrostruc- prostheses after massive resection - clinical tured short prosthetic stems - experimental results, 1 to 4 years after implantation - results in a canine model
G. U. Exner, H. A. C. Jacob, R. Bedzinski,
M. Oldenburg, C. Buschmann, R. T. Mueller
Implant biomechanics Bonewelding: thermal and mechanical char- acterisation of the bone / polymer interface In-vitro tests on cemented femoral compo-
S. Ferguson, T. Beutler, T. Lanci, L. Torriani
nents should include resting periods to obtain realistic migration characteristics Evaluation of accuracy and precision of two radiographic regimes for use with the martell computer assisted method of measuring Optomising the biomechanical environment acetabular wear of impaction bone graft in revision hip sur-
C. Bragdon, J. Martell, J. Veldhoven, D. Estok,
gery, the role of femoral stem taper angle
J. Heal, S. Gheduzzi, I. Learmonth, A. Miles
Biomaterials A new bone model for mechanical testing of Long-term in vivo degradation and bone reac- flexible intramedullary nails tion to resorbable implants from poly(l/dl)- lactide 80/20% and 70/30% P. Büchel, B. Rahn, R. Wieling, S. Gogolewski
P5 In vitro study of the influence of stem inser- tion rate and stem temperature on cement The effect of sevoflurane on poly methyl meth mantle porosity in cemented hip replacements acrylate. Implications at the bone cement inerface in joint arthroplasty. An in vitro study
S. Kutty, A. Devitt, A. Fanning, D. Mulcahy,
A comparison of deviatoric & volumetric bone remodelling signal predictions applied to the thrust plate prosthesis
M. Schmitz, S. Clift, W. Taylor, D. Hertig,
Sterilization of ceramics EORS POSTER EXHIBIT The TMT porous tatalum biomaterial: Do zoledronate and titanium particles have a ultrastructural characterization synergetic effect on osteoblasts? Cartilage biology Suramin affects human osteosarcoma cells An alternate non angiogenic function for VEGF Effects of hyperthermia on osteosarcoma cells Soft tissue biology The influence of ion channel modulators on the cd44 expression of human chondrocytes Oral acorbate supplementation reduces skele- tal muscle reperfusion injury S. Kearns, A. Daly, C. Condron, The significance of MIA/CD-RAP in the diag- nosis and monitoring of cartilage degradation N-acetyl cysteine protects skeletal muscle from compartment syndrome induced injury S. Kearns, C. Condron, D. Bouchier-Hayes, Bone biology
P18 Compartimental bone morphometry in the Cytokines and growth factors in the protrud- ed intervertebral disc of the lumbar spine N. Specchia, A. Pagnotta, A. Toesca, Effects of experimentally-induced periosteal alterations on longitudinal bone growth Expression of nerve growth factor and its receptors in human mature cartilaginous tis- sues A. Gigante, C. Bevilacqua, A. Pagnotta, N. Specchia, F. Greco EORS POSTER EXHIBIT Tissue engineering The influence of ovariectomy, low protein diet, Association between SF-36 scores and progno- and treatment with essential amino acids on sis for autologous chondrocyte implantation the nanomechanical properties of rat verte- of the knee
B. Le Gros, S. Hengsberger, P. Ammann,P. Zysset
P28 Age-related changes in yield, proliferation, and tissue forming capacity of human articu- The cause of subchondral bone cysts in lar chondrocytes osteoarthritis: a finite element analysis
H. R. Dürr, H. Martin, C. Pellengahr, V. Jansson
O. Démarteau, M. Koerner, P. Mainil-Varlet,I. Martin
Imaging and trabecular architecture Feasibility of novel clinical-CT and micro- DNA fragmentation and KI-67 expression in finite element techniques for mechanical eval- matrix associated chondrocyte transplanta- uation of human vertebrae tion (MACT)
J. Gille, B. Martens, M. Russlies, P. Behrens
Mechanically regulated bone-cell metabolism Effects of a porous graded hydroxyapatyte explains post-menopausal osteoporosis purely loaded with TGF-b on growth and differentia- as a response to increased osteoclast activation tion of human osteoblast-like cells frequency
N. Specchia, A. Pagnotta, M. Cappella, F. Greco
R. Ruimerman, P. Hilbers, B. van Rietbergen,R. Huiskes
P31 A gene therapy approach to accelerate frac- ture healing - evaluation of gene expression Investigation of microcracks in trabecular and host immune response in a sheep model bone using synchrotronradiation based micro-computed tomography (srµCT)
P. Thurner, M. Stampanoni, J. A. Hubbell,R. Mueller
Bone biomechanics Soft tissue biomechanics Multiaxial loading of a synthetic foam model for trabecular bone Relocation of the maximal stresses and strains in the articular cartilage after meniscectomy W. Wilson, C. van Donkelaar, B. van Rietbergen, R. Huiskes EORS POSTER EXHIBIT Development of a method for measurement of Reinforcement of the proximal femur with anisotropic and inhomogeneous solute diffu- cortoss bone cement. An in vitro study sion in compressed cartilage
P. Heini, J. Beckmann, A. Butscher, B. Gasser
Surgical techniques Mechanically induced electrical potentials in Optimal positioning of total hip implants for articular cartilage - what is the significance of maximal range of motion in computer-assist- polarisation potentials? ed orthopaedic surgery Joint biomechanics Intra-operative force measurement of Kinematics of the knee after anterior cruciate impaction allografting ligament reconstruction and the abolition of
K. Phipps, J. Saksena, S. Muirhead-Allwood,
pivot shift Clinical studies Knee joint reactive force after tibial lengthen- 10 year follow up of the Furlong HA coated ing and its relevance to the distracted muscle total hip replacement A possible role of fibrocartilage in rotator cuff The three-dimensional anatomy of the hip in congenital hip dysplasia. Radiographic and CT-scan analysis of 312 cases
J. N. Argenson, X. Flecher, E. Ryembault,P. H. Valloton, J. M. Aubaniac
P44 Mathematical description of the interrelation- ship of the deltoid and supraspinatus muscles Prolonged enoxaparin therapy to prevent in shoulder abduction in the scapular plane venous thromboembolism after primary hip or knee replacement: a cost-effectiveness analysis Fracture
P45 An in vivo experimental comparison of stain- less steel and titanium schanz screws in exter- nal fixation A. Ganser, R. Thompson, I. Tami, A. Steiner, K. Ito EORS POSTER EXHIBIT
P53 A new modality to reduce post acute ankle edema in ankle sprains K. Moholkar, R. Kumar, P. Borton, H. Smyth, G. Fenelon
P54 Effect of hyaluronic acid in the facet joint - a controlled, masked-observer, unicentric study of hyaluronic acid versus cortisone injections S. Fuchs, T. Erbe, H. L. Fischer, C.O. Tibesku
P55 Is there a role for androgen receptors in Dupuytren contracture? A. Pagnotta, N. Specchia, A. Medici
P56 Interpretation of EMG signals in children with cerebral palsy supported by fuzzy logic B. Schmidt-Rohlfing, C. Disselhorst-Klug, S. Ziegler, G. Rau, F.U. Niethard
P57 On an aditional practical gait assessment after total hip arthroplasty L. Angelova, Y. Toshev, B. Vladimirov
P58 Sagittal axis translation in normal and anteri- or cruciate deficient knees S. Scott, J. Moorehead, S. Montgomery
P59 The trunk stabilizing reactions of walking horse rider M. Vilimek, A. Donat, B. Nohavova
Help for your patients who suffer from specific Unlike other anxiety disorders, specific phobias Specific phobias are the most prevalent and primordial of anx- iety disorders. Long lists of phobias with myriad Greek rootsare often cited in consumer press articles on anxiety, but generally do not respond these terms are of little use to clinicians. The research and clinical literat
Prevention and Management of GastroesophagealVarices and Variceal Hemorrhage in CirrhosisGuadalupe Garcia-Tsao,1 Arun J. Sanyal,2 Norman D. Grace,3 William Carey,4 and the Practice Guidelines Committee ofthe American Association for the Study of Liver Diseases, the Practice Parameters Committeeof the American College of GastroenterologyThis guideline has been approved by the American Asso-st