Microsoft word - algo jul 2012 final

September 2012- Version n°22
ANRS - AC 11 : RESISTANCE GROUP
GENOTYPE INTERPRETATION: NUCLEOSIDE AND NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS
Mutations associated with resistance
Mutations associated with " possible resistance "
 T215Y/F
 T215A/C/D/E/G/H/I/L/N/S/V [1, 2, 3, 4]
 At least 3 mutations among : M41L, D67N, K70R, L210W,
T215A/C/D/E/G/H/I/L/N/S/V, K219Q/E [1, 2, 3, 4]
 Q151M
 Insertion at codon 69
 M184V/I
K65R [11, 12, 16]
Insertion at codon 69
 Q151M
 At least a score of + 2 among: M41L + T69D + 215Y/F + K219Q/E - K70R
 K65R [11, 12]
- M184 V/I [5, 14, 15, 17, 18]
 L74V/I [19]
 Q151M
 Insertion at codon 69
 V75A/M/S/T
 T215A/C/D/E/G/H/I/L/N/S/V [4, 7]
 T215Y/F [6]
 At least 3 mutations among : M41L, D67N, K70R, L210W,
T215A/C/D/E/G/H/I/L/N/S/V, K219Q/E [4, 7, 14, 15]
 K65R [30, 31, 32]
 Q151M
 Insertion at codon 69
 At least 4 mutations among : M41L, D67N, M184V/I, L210W, T215Y/F [8,
 3 mutations among : M41L, D67N, M184V/I, L210W,
T215Y/F [8, 19, 29]
K65R [9, 11, 12]
 L74V/I [24, 25, 26, 27, 28, 29]
 Y115F
 Q151M
 Insertion at codon 69
 At least 6 mutations among: M41L, E44D, D67N, T69D/N/S, L74V/I,
 3, 4 or 5 mutations among: M41L, E44D, D67N,
L210W, T215Y/F [13, 20, 33]
T69D/N/S, L74V/I, L210W, T215Y/F [13, 33]
K65R [9, 10, 11, 12]
 Insertion at codon 69
K70E [21, 22, 23]
ZDV: zidovudine, 3TC: lamivudine, FTC: emtricitabine, ddI: didanosine, d4T: stavudine, ABC: abacavir, TDF: tenofovir
September 2012- Version n°22
ANRS - AC 11 : RESISTANCE GROUP
GENOTYPE INTERPRETATION: NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
Mutations associated with resistance
Mutations associated with " possible resistance "
 L100I
 K101E
 K103H/N/S/T [1]
 V106M [2]
 E138K [12, 13]
 Y181C/I
 Y188C/L
 G190A/C/E/Q/S/T/V
 P225H
 M230L
 A98S (for HIV-1 subtype C only) [3]
 E138K [13]
 L100I
 K101E
 K103H/N/S/T [1]
 V106A/M [2]
 Y181C/I
 Y188C/H/L
 G190A/C/E/Q/S/T/V
 M230L
 At least 4 among: V90I, A98G, L100I,
 3 mutations among: V90I, A98G, L100I, K101E/H/I/P/R,
K101E/H/I/P/R, V106I, V179D/F/I/L/M/T, Y181C/I,
V106I, V179D/F/I/L/M/T, Y181C/I, G190A/S,M230L [4, 7, 8,
G190A/S,M230L [4, 7, 8, 9, 10, 11]
9, 10, 11]
E138K [12, 13]
 Y181V [5, 6]
 E138A/G/Q/R [5, 6, 7, 8]
 Y181C+H221Y [7]

 K101E/P [9, 13]
 E138A/G/K/Q/R/S [12, 13, 14]
 V179L [9]
 Y181C/I/V [13]
 Y188L [9]
 H221Y [13]
 M230I/L/V [9]
 L100I + K103N [9]
EFV: efavirenz, NVP: nevirapine, ETR: etravirine, RPV : rilpivirine
September 2012- Version n°22
ANRS - AC 11 : RESISTANCE GROUP
GENOTYPE INTERPRETATION: PROTEASE INHIBITORS
Mutations associated with resistance
Mutations associated with " possible resistance "
 M46I/L
V82A/F/M/S/T [11]
 I84A/V [8]
 L90M and at least 2 among : K20M/R, L24I, V32I, M36I,
I54V/L/M/T, A71V/T, G73S/A, V77I
 At least 4 mutations among: L10F/I/M/R/V, I15A/V, K20I/M/R/T,
 3 mutations among: L10F/I/M/R/V, I15A/V, K20I/M/R/T, L24I,
1000/100 mg
L24I, I62V, G73S/T, V82A/F/S/T, I84V, L90M [9]
I62V, G73S/T, V82A/F/S/T, I84V, L90M [9]
V82A/F/S/T and at least 2 among: L10I, M36I, M46I/L,
I84A/V [8]
I54V/L/M/T, A71V/T, V77I [1]
 L90M
 I50V
 V32I and I47A/V [2, 13, 14]
700/100 mg BID
At least 4 mutations among: L10F/I/V, L33F, M36I,
I54A/L/M/S/T/V, I62V, V82A/C/F/G, I84V, L90M [2, 20]
 At least 6 mutations among : L10F/I/R/V, K20M/R, L24I, L33F,
 4 or 5 mutations among: L10F/I/R/V, K20M/R, L24I, L33F,
M46I/L, I50V, F53L, I54M/L/T/V, L63P, A71I/L/V/T, V82A/F/S/T,
M46I/L, I50V, F53L, I54M/L/T/V, L63P, A71I/L/V/T,
I84V, L90M [3, 4, 5, 21]
V82A/F/S/T, I84V, L90M [3, 4, 5, 21]
 I47A [15, 16]
 L76V [18, 19]
 I50L [6]
300/100 mg QD
 N88S [28,29,30]
 At least 3 mutations among: L10F/I/V, G16E, L33F/I/V, M46I/L,
D60E, I84V, I85V, L90M [7, 12, 22]
 At least a score of + 3* : 36I/L/V - 53L/W/Y + 58E +
 A score of + 2* : 36I/L/V - 53L/W/Y + 58E + 69I/K/N/Q/R/Y +
69I/K/N/Q/R/Y + 89I/M/R/T/V [10, 23]
89I/M/R/T/V [10, 23]
500/200 mg BID
 At least 4 mutations among: V11I, V32I, L33F, I47V, I50V,
 3 mutations among: V11I, V32I, L33F, I47V, I50V, I54L/M,
I54L/M, T74P, L76V, I84V, L89V [17, 24, 25, 26]
T74P, L76V, I84V, L89V [17, 24, 25, 26]
600/100 mg BID
September 2012- Version n°22
IDV: indinavir, SQV: saquinavir, NFV: nelfinavir, RTV: ritonavir, FPV: fosamprenavir, LPV: lopinavir, ATV:atazanavir, TPV: tipranavir,
DRV : darunavir

* Insufficient data for HIV-1 subtype non-B
September 2012- Version n°22
ANRS - AC 11 : RESISTANCE GROUP
GENOTYPE INTERPRETATION: FUSION INHIBITOR
Mutations associated with resistance
 G36A/D/E/S/V [1, 2, 3, 4, 5, 6, 7]
 V38A/E/K/M
 Q40H/K/P/T
 N42D/T
 N43D/H/K/S
 L45Q/M
ENF (T20): enfuvirtide
September 2012- Version n°22
ANRS - AC 11 : RESISTANCE GROUP
GENOTYPE INTERPRETATION: INTEGRASE INHIBITORS
Mutations associated with resistance
Mutations associated with " possible resistance "
 T66K [10]
 E92Q [1, 2]
 G118R [10]
 F121Y [10]
 G140A/S [7]
 Y143C/G/H/R/S [1, 3, 4, 5, 8]
 Q148E/G/H/K/R [1, 2]
 V151L [9]
 N155H/S/T [1, 2, 9]
 E157Q [2]
 T66I/A/K [6]
 E92Q [6]
 F121Y [9]
 E138K
 G140C/S
 P145S [9]
 S147G
 Q148H/R/K [6]
 V151L [9]
 N155H/S/T [6,9]
 E157Q [11]
 G118R [12,13]
 T66K [9]
 V151L [9]
 S153F
 S153Y
 T66K + L74M
 E92Q + N155H
 E138A/K + Q148H/K/R
 G140C/S + Q148H/K/R
 Q148R + N155H
RAL: raltegravir, EVG: elvitegravir, DTG: dolutegravir
September 2012- Version n°22
ANRS - AC 11 : RESISTANCE GROUP
GENOTYPE INTERPRETATION FOR HIV-2
NUCLEOSIDE AND NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS

 K65R : resistance to ddI, TDF, ABC [1]
 Q151M : all NRTI except 3TC and FTC [1]
 M184V : resistance to 3TC/FTC [1]
 S215A/C/F/L/P/Y : resistance to AZT and d4T [1]
NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

 Naturally resistant to all NNRTI [2, 3]

PROTEASE INHIBITORS

 Naturally resistant to APV and fosAPV [2, 3]
Contradictory data for ATV , TPV [2, 4]

FUSION INHIBITOR

 Naturally resistant to T20 [2, 3]
INTEGRASE INHIBITORS

 Y143C/H/R : resistance to raltegravir [7]
 Q148K/R : resistance to raltegravir [5]
 N155H : resistance to raltegravir [6]
September 2012- Version n°22
REFERENCES
Nucleoside and Nucleotide Reverse Transcriptase Inhibitors
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