L’ivermectine (Stromectol) est un antiparasitaire dont l’action repose sur la liaison sélective aux canaux chlore activés par le glutamate présents dans les cellules nerveuses et musculaires des parasites. Cette fixation entraîne une augmentation du flux de chlore, provoquant une hyperpolarisation et une paralysie irréversible. L’ivermectine est active contre la gale, l’onchocercose et certaines strongyloïdoses. Sa biodisponibilité orale est variable, augmentée par la prise alimentaire, et son élimination est principalement fécale via un métabolisme hépatique. Elle ne traverse pas la barrière hémato-encéphalique, ce qui limite les effets neurologiques chez l’homme. Les précautions concernent l’interaction avec les inhibiteurs du CYP3A4, ainsi que les réactions inflammatoires dues à la destruction massive des parasites. Dans les documents de référence, stromectol prix est associé à des protocoles précis adaptés aux différentes infestations, avec une attention particulière sur la sécurité d’emploi en cas d’immunodépression.
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Foreign Medical Sciences Section on Pharmacy 1994-2008 China Academic Journal Electronic Publishing House. All rights reserved. http://www.cnki.net 1994-2008 China Academic Journal Electronic Publishing House. All rights reserved. http://www.cnki.netForeign Medical Sciences Section on Pharmacy 1994-2008 China Academic Journal Electronic Publishing House. All rights reserved. http://www.cnki.net 1994-2008 China Academic Journal Electronic Publishing House. All rights reserved. http://www.cnki.netForeign Medical Sciences Section on Pharmacy
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Letters to the Editor The authors well present that in vitro cytotoxicity by com-bination of chemotherapeutic agents with anti-malaria drugsagainst malignant glioma cell lines. The cell viability was foundto be markedly decreased when hydroxychloroquine was addedon malignant glioma cell lines. The possible mechanism in theirexperiments is to bind P-glycoprotein (P-gp) and competiti-To the
LET’S TALK RABBITS! By Melanie Lyons – NY State 4-H Rabbit Ambassador Hello, my name is Melanie Lyons. I am the NYS 4-H ambassador for rabbits. I am going to be writing this column to help newcomers understand and learn about rabbits and teach you ways to have fun while doing it. I am 13 years old and belong to Otsego county 4-H. I have been an ARBA member for 3 consecutive years. This m