Nitrkl.ac.in2

Curriculum Vitae
Dr. Sujit Kumar Bhutia
Department of Life Science
National Institute of Technology Rourkela
Rourkela - 769008
Odisha, India
Phone-91-661-2462686
Fax: 91-661-2462999
Email:
Education
PhD, Indian Institute of Technology, Kharagpur, India, 2009
MSc, Utkal University, Odisha, India, 2003
BSc, Govt College Angul, Utkal University, Odisha, India, 2001
Professional Experience
Assistant Professor, National Institute of Technology Rourkela, India, Since 2008
Postdoctoral fellow, Virginia Commonwealth University, USA, 2008-2010
Academic Awards/Honors
Rapid grant for young investigator (RGYI)-2010 supported by Department of Biotechnology,
India
National Doctoral Fellow-2005 (AICTE), Indian Institute of Technology, Kharagpur
Awarded CSIR-Junior research fellowship, 2004
Qualified GATE- 2004 with 99.25 percentile, All India rank-31
Research Interests
1) Role of autophagy in tumor therapy. What is the present state of our knowledge about the
role of autophagy in cancer development, and in response to therapy? And how can the
autophagic process are manipulated to improve anticancer therapeutics? Manipulation of
autophagy has the potential to improve anticancer therapeutics. When tumor cells induce
protective autophagy, inhibition of autophagy could sensitize tumor cells to the treatment by
activating apoptosis. On the other hand, induction of autophagic cell death can also have a
therapeutic value.
2) Targeting cancer stem/initiating cells for novel therapy. Prominent in the cancer field has
been the notion of the existence of a transformed population of cells with many of the properties
of stem cells that may be responsible for the origin and maintenance of tumors. These cancer
stem cells might play an important role in cancer establishment, progression, and resistance to
current treatments. Therapies aimed at targeting cancer stem cells may prove clinically relevant
in inducing long-term clinical remission of cancer.
Courses Taught at NIT Rourkela
1. Cell Biology 2. Cell signaling 3. Enzyme and metabolism 4. Cancer biology
Supervision of Students
Doctoral Students (PhD): 05 ongoing
Member:
American Association in cancer research
Indian Association in cancer research
Research Grant:
1. Deciphering role of cancer stem cells to therapy resistance in oral cancer, Govt of India
Sponsor: DST Govt. of. India (Aproved); Principal Investigator: Dr. S K Bhutia; Co- 2. Autophagic cell death induction with Abrus agglutinin; Sponsor: DBT Govt. of. India (2012- 2014); Principal Investigator: Dr. S K Bhutia; Co-investigator: Dr. S Paul Publications: 38
38. Bhutia SK, Behera B,Das DN, Mukhopadhaya S, Sinha N, Panda PK, Patra SK, Sarkar S,
Menezes M, Maiti TK, Das SK, Sarkar D, Fisher PB. Abrus Agglutinin induced antitumor effect
through caspase 8 activation by ROS generation and IGFBP-2 mediated angiogenesis inhibition
in breast cancer. PlosOne (press)
37. Azab B, Dash R, Das SK, Bhutia SK, Sarkar S, Shen XN, Quinn BA, Dent P, Dmitriev IP, Wang XY, Curiel DT, Pellecchia M, Reed JC, Sarkar D, Fisher PB. Enhanced prostate cancer gene transfer and therapy using a novel serotype chimera cancer terminator virus (Ad.5/3-CTV). J Cell Physiol (press) 36. Bhutia SK, Das SK, Azab B, Menezes M Dent P, Wang XY, Sarkar D, Fisher PB Targeting
breast cancer stem/initiating cells with melanoma differentiation associated gene-7/Interleukin-
24 (mda-7/IL-24). Int. J cancer (press)
35. Das SK, Bhutia SK, Azab B, Kegelman TP, Peachy L , Santhekadur PK, Dasgupta S, Dash
R , Dent P, Grant S, Emdad L, Pellecchia M, Sarkar D, Fisher PB. MDA-9/Syntenin and IGFBP-
2 Promote Angiogenesis in Human Melanoma. Cancer Res. 2013;73:844-54.
34. Venkatesan P, Bhutia SK, Singh AK, Das SK, Dash R, Chaudhury K, Sarkar D, Fisher PB,
Mandal M. AEE788 potentiates celecoxib-induced growth inhibition and apoptosis in human
colon cancer cells. Life Sci. 2012 Oct 22;91(15-16):789-99
33. Das SK, Bhutia SK, Sokhi UK, Azab B, Su ZZ, Boukerche H, Anwar T, Moen EL,
Chatterjee D, Pellecchia M, Sarkar D, Fisher PB. Raf Kinase Inhibitor RKIP Inhibits MDA-
9/Syntenin-Mediated Metastasis in Melanoma. Cancer Res. 2012 ;72:6217-26.
32. Kar S, Deb M, Sengupta D, Shilpi A, Bhutia SK, Patra SK. Intricacies of hedgehog
signaling pathways: A perspective in tumorigenesis. Exp Cell Res. 2012;318:1959-72
31. Maiti S, Mallick SK, Bhutia SK, Behera B, Mandal M, Maiti TK. Antitumor effect of
culinary-medicinal oyster mushroom, Pleurotus ostreatus (Jacq.: Fr.) P. Kumm., derived protein
fraction on tumor-bearing mice models. Int J Med Mushrooms. 2011;13(5):427-40.
30. Das SK, Bhutia SK, Kegelman TP, Peachy L, Oyesanya RA, Dasgupta S, Sokhi UK, Azab
B, Dash R, Quinn BA, Kim K, Barral PM, Su ZZ, Boukerche H, Sarkar D, Fisher PB. MDA-
9/syntenin: a positive gatekeeper of melanoma metastasis. Front Biosci. 2012; 17:1-15.
29. Chen D, Yoo BK, Santhekadur PK, Gredler R, Bhutia SK, Das SK, Fuller C, Su ZZ, Fisher
PB, Sarkar D. Insulin-like Growth Factor-Binding Protein-7 Functions as a Potential Tumor
Suppressor in Hepatocellular Carcinoma. Clin Cancer Res 2011; 17:6693-701.
28. Azab B, Dash R, Das SK, Bhutia SK, Shen XN, Quinn BA, Sarkar S, Wang XY, Hedvat M,
Dmitriev IP, Curiel DT, Grant S, Dent P, Reed JC, Pellecchia M, Sarkar D, Fisher PB. Enhanced
delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the
Apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR
colorectal cancer cells. J Cell Physiol. 2011; 227(5):2145-5
27. Bhutia SK, Das SK, Kegelman TP, Azab B, Dash R, Su ZZ, Wang XY, Rizzi F, Bettuzzi S,
Lee SG, Dent P, Grant S, Curiel DT, Sarkar D, Fisher PB. mda-7/IL-24 differentially regulates
soluble and nuclear clusterin in prostate cancer. J Cell Physiol. 2011; 227(5):1805-13.
26. Bhutia SK, Das SK, Azab B, Dash R, Su ZZ, Lee SG, Grant S, Yacoub A, Dent P, Curiel
DT, Sarkar D, Fisher PB. melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-
24)-induced autophagy switches to apoptosis in prostate cancer cells. Autophagy 2011;7:1076-7.
25. Bhutia SK, Kegelman TK, Das SK, Azab B , Su ZZ, Lee SG, Sarkar D, Fisher PB.
Astrocytes elevated gene-1 activate AMPK in response to cellular metabolic stress and
associated with protective autophagy. Autophagy 2011;7:1076-7.
24. Mallick SK, Maiti S, Bhutia SK, Maiti TK. Activation of RAW 264.7cells by Astraeus
hygrometricus derived Heteroglucan through MAP kinase pathway. Cell Biol Int. 2011 35:617-
21.
23. Bhutia SK, Kegelman TK, Das SK, Azab B , Su ZZ, Lee SG, Sarkar D, Fisher PB.
Astrocyte elevated gene-1 induces protective autophagy. Proc Natl Acad Sci U S A. 2010;
107:22243-8.
22. Dash R, Bhutia SK, Azab B, Su ZZ, Quinn BA, Kegelmen TP, Das SK, Kim K, Lee SG,
Park MA, Yacoub A, Rahmani M, Emdad L, Dmitriev IP, Wang XY, Sarkar D, Grant S, Dent P,
Curiel DT, Fisher PB. mda-7/IL-24: A unique member of the IL-10 gene family promoting
cancer-targeted toxicity. Cytokine Growth Factor Rev 2010; 21(5):381-91.
21. Dent P, Yacoub A, Hamed HA, Park MA, Dash R, Bhutia SK, Sarkar D, Wang XY, Gupta
P, Emdad L, Lebedeva IV, Sauane M, Su ZZ, Rahmani M, Broaddus WC, Young HF, Lesniak
MS, Grant S, Curiel DT, Fisher PB. The development of MDA-7/IL-24 as a cancer therapeutic.
Pharmacol Ther. 2010; 128:375-84.
20. Dent P, Yacoub A, Hamed HA, Park MA, Dash R, Bhutia SK, Sarkar D, Gupta P, Emdad L,
Lebedeva IV, Sauane M, Su ZZ, Rahmani M, Broaddus WC, Young HF, Lesniak M, Grant S,
Curiel DT, Fisher PB. MDA-7/IL-24 as a cancer therapeutic: from bench to bedside. Anticancer
Drugs. 2010; 21:725-31.
19. Das SK, Sokhi UK, Bhutia SK, Azab B , Su ZZ, Sarkar D, Fisher PB. Human
polynucleotide phosphorylase selectively and preferentially degrades microRNA-221 in human
melanoma cells. Proc Natl Acad Sci USA 2010; 107:11948-53.
18. Mallick SK, Maiti S, Bhutia SK, Maiti TK. Immunostimulatory properties of a
polysaccharide isolated from Astraeus hygrometricus. J Med Food 2010;13:665-72.
17. Mallick SK, Maiti S, Bhutia SK, Maiti TK. Antitumor properties of a Heteroglucan isolated
from Astraeus hygrometricus on Dalton's Lymphoma bearing mouse. Food Chem Toxicol 2010;
48; 2115-21.
16. Dash R, Richards JE, Su ZZ, Bhutia SK, Azab B, Rahmani M, Dasmahapatra G, Yacoub A,
Dent P, Dmitriev IP, Curiel DT, Grant S, Pellecchia M, Reed JC, Sarkar D, Fisher PB.
Mechanism by which Mcl-1 regulates cancer-specific apoptosis triggered by mda-7/IL-24, an IL-
10-related cytokine. Cancer Res 2010;70:5034-45.
15. Bhutia SK, Dash R, Das SK, Azab B, Su ZZ, Lee SG, Grant S, Yacoub A, Dent P, Curiel
DT, Sarkar D, Fisher PB. Mechanism of autophagy to apoptosis switch triggered in prostate
cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24.
Cancer Res 2010;70:3667-76.
14. Bhutia SK, Mallick SK, Maiti TK. Tumour escape mechanisms and their therapeutic
implications in combination tumour therapy. Cell Biol Int 2010;34:553-63.
13. Dash R, Dmitriev I, Su ZZ, Bhutia SK, Azab B, Vozhilla N, Yacoub A, Dent P, Curiel DT,
Sarkar D, Fisher PB. Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus
(Ad.5/3) improves therapeutic efficacy in low CAR prostate cancer cells. Cancer Gene Ther
2010; 1-10.
12. Mallick SK, Bhutia SK, Maiti TK. Macrophage Stimulation by Polysaccharides Isolated
from
(Gasteromycetideae). International Journal of Medicinal Mushrooms 2009; 11: 237-48. 11. Bhutia SK, Mallick SK, Maiti S, Mishra D, Maiti TK. Abrus abrin derived peptides induce
apoptosis by targeting mitochondria in HeLa cells. Cell Biol Int 2009; 33:720-27.
10. Bhutia SK, Mallick SK, Maiti TK. In vitro immunostimulatory properties of Abrus lectins
derived peptides in tumor bearing mice. Phytomedicine. 2009; 16:776-82.
9. Ghosh D, Bhutia SK, Mallick SK, Banerjee I, Maiti TK. Stimulation of murine B and T
lymphocytes by native and heat-denatured Abrus agglutinin. Immunobiology. 2009;214:227-34.
8. Bhutia SK, Mallick SK, Maiti S, Maiti TK. Inhibitory effect of Abrus abrin-derived peptide
fraction against Dalton's lymphoma ascites model. Phytomedicine. 2009;16:377-385.
7. Bhutia SK, Maiti TK. Targeting tumors with peptides from natural sources. Trends
Biotechnol. 2008; 26:210-217.
6. Bhutia SK, Mallick SK, Maiti S, Maiti TK. Antitumor and proapoptotic effect of Abrus
agglutinin derived peptide in Dalton's lymphoma tumor model. Chem Biol Interact 2008;174:11-
18.
5. Maiti S, Bhutia SK, Mallick SK, Kumar A, Khargi N, Maiti TK. Antiproliferative and
immunostimulatory protein fraction from edible mushrooms. Environmental Toxicology and
Pharmacology 2008; 26; 187-191.
4. Bhutia SK, Mallick SK, Stevens SM, Prokai L, Vishwanatha JK, Maiti TK. Induction of
mitochondria-dependent apoptosis by Abrus agglutinin derived peptides in human cervical
cancer cell. Toxicol In Vitro. 2008;22:344-351.
3. Das T, Mallick SK, Paul D, Bhutia SK, Bhattacharyya TK, Maiti TK. Microcontact printing
of Concanavalin A and its effect on mammalian cell morphology. J Colloid Interface Sci 2007;
314:71-79.
2. Shah S, Ghosh D, Sarangi I, Mallick SK, Bhutia SK, Banerjee I, Maiti S, Maiti TK.
Immunomodulatory and Antitumor Activities of Water-Soluble Proteoglycan Isolated from the
Fruiting Bodies of Culinary-Medicinal Oyster Mushroom Pleurotus ostreatus (Jacq.: Fr.) P.
Kumm. (Agaricomycetideae). International Journal of Medicinal Mushrooms 2007; 9: 123-138
1. Sarangi I, Ghosh D, Bhutia SK, Mallick SK, Maiti TK. Antitumor and immunomodulating
effects of Pleurotus ostreatus mycelia-derived proteoglycans. Int Immunopharmacol
2006;6:1287-97.
Book chapter:
1. Bhutia SK and Maiti TK. Crabs Eye (Abrus precatorius) seed and its immunomodulatory and
antitumor properties. In: Preedy VR, Watson RR, Patel VB editor. Nuts and seeds in Health and
Disease Prevention. Academic Press 2011. P409-415
2. Bhutia SK, Mukhopadhaya S, Sinha N, Das DN, Panda PK, Patra SK, Maiti TK, Mandal M,
Dent P, Wang XY, Das SK, Sarkar D, Fisher PB. Autophagy: Cancer's Friend or Foe? Adv
Cancer Res. 2013;118:61-95
Conference:
International:
1. Bhutia SK, Dash R, Das SK, Azab B, Su ZZ, Lee SG, Grant S, Yacoub A, Dent P, Curiel DT,
Sarkar D, Fisher PB. Mechanism of Autophagy to Apoptosis Switch Triggered in Prostate
Cancer Cells by Antitumor Cytokine Melanoma Differentiation-Associated Gene 7/Interleukin-
24. 101th American Association of cancer research (2010).
2. Bhutia SK, Dash R, Das SK, Azab B, Su ZZ, Lee SG, Grant S, Yacoub A, Dent P, Curiel DT,
Sarkar D, Fisher PB. Azab B, Dash R, Bhutia SK, Sarkar D, Claudio PP, Fisher PB. In vivo
molecular delivery of therapeutic molecules ssing microbubbles and ultrasound. Cold Spring
Harbor (CSH) In vivo barriers to gene delivery conference (2009).
3. Bhutia SK, Das SK, Sarkar D, Fisher PB. Astrocyte elevated gene-1 activates AMPK in
response to cellular metabolic stress and promotes protective autophagy. Autophagy conference
2011.
National:
1. Bhutia SK, Maiti TK. In vitro and In vivo antitumor properties of Abrus agglutinin derived
peptides, 27th Annual convention of IACR (2008).
2. Bhutia SK, Ghosh D, Mallick SK, Viswanatha JK, Maiti TK. Immunomodulatory and
anticancer properties of tryptic peptides from Abrus agglutinin. First Indian peptide symposium
(2007).
3. Mallick SK, Bhutia SK, Maiti S, Maiti TK. Immunomodulatory and anticancer glucan from
Astraeus hygrometricus. 34th Indian Immunology Society (IIS) Conference (2007).
4. Ghosh D, Bhutia SK, Mallick SK, Maiti TK. Activation of murine B and T lymphocytes by
native and heat-denatured Abrus agglutinin, 33rd Indian Immunology Society (IIS) Conference
(2007).
5. Maiti S, Bhutia SK, Mallick SK, Kumar A, Khadgi N, Maiti TK. Exploring the
antiproliferative effect of edible mushroom fruiting body derived proteins on different tumor cell
lines. 26th Annual Convention of IACR & International Symposium on translational research in
cancer (2006).
6. Sarangi I, Ghosh D, Bhutia SK, Maiti TK. Immunomodulatory and anticancer effects of
Pleurotus ostreatus mycelia derived proteoglycans. 24th Annual Convention of IACR &
International Symposium on "HPV and Cervical Cancer" (2005).
1. Dr. Tapas K. Maiti
Professor
Department of Biotechnology
Indian Institute of Technology Kharagpur
Kharagpur-721302, West Bengal, India Tel: 0091-3222-283766; Fax: 0091-3222-255303 E-mail:2. Dr. Paul B. Fisher Professor and Department Head Director, VCU Institute of Molecular Medicine, Thelma Newmeyer Corman Chair in Cancer Research, VCU Massey Cancer Center Human and Molecular Genetics Molecular Medicine Research Building, 7-048 and 7-050 Richmond, VA 23298 Phone: 804-628-3506; Fax: 804-827-1124 E-mail:

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