Niperahm.edu.in
Dr. MANISH NIVSARKAR
B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Sarkhej-
Gandhinagar Highway, Thaltej, Ahmedabad-380054
Telephone: 91 79 27439375, Fax: 91 79 27450449
Current Position:
Director
……………………………………………………………………………………………………………
Joint Director, Head Department of Pharmacology and Toxicology: B. V. Patel PERD
Assistant Director, Head Department of Pharmacology and Toxicology: B. V. Patel
Scientist-C, Head Department of Pharmacology and Toxicology: B. V. Patel PERD
Scientist-B, Head Department of Pharmacology and Toxicology: B. V. Patel PERD
Scientist A: Department of Pharmacology and Toxicology: B. V. Patel PERD Centre,
Research Scientist: M.R.S. Hurkisondas Narrotamdas Hospital Mumbai, 1993-96
Research Associate (CSIR): School of Life Sciences
, Devi Ahilya University, Indore,
……………………………………………………………………………………………………………
Ph.D. (Life Sciences), Thesis title: “Biochemical mechanism behind the phototoxicity
of α-terthienyl: Its use as a mosquito control agent” - Devi Ahilya University Indore, 1988-
M. Sc. (Animal Sciences) - Rohilkhand University Bareilly, 1985-1987.
……………………………………………………………………………………………………………
Toxicology, Molecular Pharmacology, Drug Delivery, Biomarkers, Reproductive
Physiology, Diabetes and its complications and Inflammatory disorders.
……………………………………………………………………………………………………………
“New topical formulation of Berberine & its derivative tetrahydroberberine for post kala-
azar Leishmaniasis” Hemangi Bagadiya, Hitesh B. Jalani, Kamala K. Vasu,
Manish
Nivsarkar. Presented in
3rd CDRI-NIPER (RBL) Symposium on Medicinal Chemistry
and Pharmaceutical Sciences CDRI, Luknow, 3-5 March, 2011, (
This poster won the
1st prize).
Ranjeet Prasad Dash, Bhupendrasinh F. Chauhan, Sheetal Anandjiwala, Manish
Nivsarkar. Certificate of Merit - “
Dr. P.D. Sethi Annual Award for Best Paper in
Pharmaceutical Analysis”
2010.
Pradeep Dabhi, Sheetal Anandjiwala, Manish Nivsarkar.
1st Prize in 14th National
Convention of Society of Pharmacognosy, Hindu College of Pharmacy, Sonipat,
Nimesh Modi, Sheetal Anandjiwala, Manish Nivsarkar.
3rd Prize in 14th National
Convention of Society of Pharmacognosy, Hindu College of Pharmacy, Sonipat,
Baljinder Singh, Pankaj Mungara, Manish Nivsarkar, Sheetal Anandjiwala.
Certificate
of Appreciation - “Dr. P.D. Sethi Research Paper Annual Award on Application of
LC/HPTLC in Pharma, Herbal and Miscel aneous Analysis” 2009.
Baljinder Singh, Pankaj Mungara, Sheetal Anandjiwala, Manish Nivsarkar.
2nd Prize in
Gujarat State Pharmacy Paper Presentation-conducted by GUJCOST, Shri
Sarvajanik Pharmacy College Mehsana, Gandhinagar, January 2009.
Swati Pund, Amita K Joshi, Kamala K Vasu, Manish Nivsarkar.
2nd Prize in Gujarat
State Pharmacy Paper Presentation-conducted by GUJCOST, Shri Sarvajanik
Pharmacy College Mehsana, Gandhinagar, January 2009.
Aryamitra Banerjee and Manish Nivsarkar.
Govind Achari Prize. 40th Annual
Conference of Indian Pharmacological Society, NIPER-SAS Nagar, November 2007.
Aryamitra Banerjee and Manish Nivsarkar.
1st Prize in UGC-DSA Symposium on
“Recent Advances in Reproduction, Endocrinology & Development and
Associated Disorders”, The M. S. University of Baroda, Vadodara, January 2006.
Bhupendrasinh Chauhan and Manish Nivsarkar.
3rd Prize in National Symposium on
Contemporary Developments in Life Sciences, Hemchandracharya North Gujarat
……………………………………………………………………………………………………………
Singh B., Nadkarni J.R., Vishwakarma R.A., Bharate S.B., Anandjiwala, S. and
Nivsarkar, M. (2012) The hydroalcoholic extract of
Cassia alata (Linn.) leaves and its
major compound rhein exhibits antiallergic activity
via mast cell stabilization and
lipoxygenase inhibition (Available Online)
Patil, S., Dash, R. P., Anandjiwala, S. and
Nivsarkar, M. (2012) Pharmacokinetic
study of berberine from
Rasont and implication of lysergol for its bioavailability
enhancement.
Journal of Liquid Chromatography and Related Technologies
Patil, S., Dash, R.P., Anandjiwala, S. and
Nivsarkar, M. (2011) Simultaneous
quantification of berberine and lysergol by HPLC-UV: Evidence that lysergol
enhances the oral bioavailability of berberine in rats.
Biomedical Chromatography
(Accepted).
Impact Factor: 1.545
Yadav, H., Mungara, P., Jivrajani, M.,
Nivsarkar, M and Anandjiwala S.
(2011) TLC-
Densitometric Quantification of Negundoside, Ursolic Acid, Eugenol, Lupeol and β-
sitosterol using HPTLC from Vitex negundo Leaves.
Journal of Liquid
Chromatography and Related Technologies (Accepted).
Impact Factor: 0.953
Pund S., Joshi, A., Vasu, K.,
Nivsarkar, M. and Shishoo, CJ
(2011) Gastroretentive
delivery of refampicin:
in vitro mucoadhesion and
in vivo gamma scintigraphy.
International Journal of Pharmaceutics 411(1-2), 106-112.
Impact Factor:
3.607
Patel, V., Chudasama, A.,
Nivsarkar, M., Vasu, K and Shishoo, CJS
(2011) Push-
Pull osmotic pump for zero order delivery of lithium carbonate: development and
in
vitro characterization.
Pharmaceutical Development and Technology (in press,
available online).
Impact Factor:
1.107
Banerjee, A., Vasu, K., Pancholi, H., Rajani, M. and
Nivsarkar, M (2011)
Detoxification of
Nerium indicum roots based on Indian System of Medicine:
Phytochemical and Toxicological Evaluation.
Acta Poloniae-Drug Research 68(6),
Banerjee, A., Padh, H and
Nivsarkar, M. (2011) Hormonal Crosstalk with calcium
channel blocker during implantation
Systems Biology in Reproductive Medicine
Vol. 57(4), 186-189.
Impact Factor:
0.800
Shep, D., Ojha, A., Patel, S.,
Nivsarkar, M, Jaiswal, V and Padh, H
(2011)
Bioequivalence and pharmacokinetic evaluation of two formulations of fenofibrate
145 mg in healthy Indian subjects.
Journal of Pharmaceutical and Biomedical
Research 7(7) 1-5.
Joshi, A., Pund SV.,
Nivsarkar, MA., Vasu KK and Shishoo, CJ
(2011) Exploring the
potential of polacrilin potassium as a novel superdistintegrant in microcrystalline
cellulose based pellets prepared by extrusion-spheronization.
Chronicles of Young
Scientists Vol. 2(2), 114-116.
Chudasama, A., Patel V., Nivsarkar, M., Vasu, K.K. and Shishoo, CJ
(2011) A novel
lipid based oral drug delivery system of Nevirapine.
International Journal of
Pharmaceutical Technology and Research. Vol. 3(2), 1159-1168.
Chudasama, A., Patel V., Nivsarkar, M., Vasu, K.K. and Shishoo, CJ
(2011)
Investigation of microemulsion system for transdermal delivery of itraconazole.
Journal of Advanced Pharmaceutical Technology and Research Vol. 2(1), 30-38.
Shep, D., Ojha, A., Patel, S.,
Nivsarkar, M, Jaiswal, V and Padh, H
(2011)
Comparative Bioavailability Study of a New Formulation of Injection of 75 Mg
Diclofenac Sodium in 1 Ml with the Conventional Injection of 75 Mg Diclofenac
Sodium Given in 3 Ml Volume
Current Clinical Pharmacology 6(1), 26-29.
Impact
Factor:
2.500
Vyas, T., Dash, R.P., Anandjiwala, S.,
Nivsarkar, M. (2011) Formulation and
pharmacokinetic evaluation of hard gelatin capsule encapsulating lyophilized
Vasa
Swaras for improved stability and oral bioavailability of vasicine.
Fitoterapia. 82(3),
446-453.
Impact Factor:
1.899
Shep, D., Ojha, A., Patel, S.,
Nivsarkar, M, Jaiswal, V and Padh, H.
(2010)
Pharmacokinetic profile of a new formulation of injection diclofenac in Indian
volunteers with BMI > 25.
Journal of Pain Research, 3, 235-240.
Shep, D., Ojha, A., Patel, S.,
Nivsarkar, M, Jaiswal, V and Padh, H.
(2010)
Bioequivalence and pharmackokinetic evaluation of two formulations of paracetamol
ER 650 mg: A single dose randomized two period crossover comparison in healthy
Indian adult volunteers.
International Journal of Current Pharmaceutical
Research Vol. 2(4) 28-31.
Dash, R.P., Chauhan, B.F., Anandjiwala
, S.,
Nivsarkar M. (2010) Comparative
pharmacokinetics profile of Vasa Swaras with vasicine and vasicinone.
Chromatographia. 71(7), 609-615.
Impact Factor:
1.438
Pund, S., Joshi, A., Vasu, K.,
Nivsarkar, M., Shishoo, C.J.
(2010) Multivariate
optimization of formulation and process variables influencing physico-mechanical
characteristics of site-specific release isoniazid pellets.
International Journal of
Pharmaceutics. 388, 64-72.
Impact Factor:
3.607
Dash R.P. and
Nivsarkar, M (2010) Current Perspectives in Bioavailability
Enhancement. In: Souvenir, 6th International Symposium on Pharmaceutical
Innovation in Science and Technology, Nov. 26-28th, 2010, Ahmedabad, India.
Thakur, S. and
Nivsarkar, M (2010) Applications of Bioinformatics. In: Souvenir, 6th
International Symposium on Pharmaceutical Innovation in Science and Technology,
Chauhan, B. and
Nivsarkar, M (2010) Future Prospects for CRO: Indian Capabilities.
Mahajan, S., Banerjee, A., Chauhan, B., Padh, H.,
Nivsarkar, M. and Mehta, A.
(2009) Inhibitory Effect of n-butanol fraction of
Moringa oleifera Lam. Seeds on OVA-
Induced Airway Inflammation in murine model of asthma.
International Journal of
Toxicology 28(6), 519-527.
Impact Factor:
1.243
Singh, B, Mungra, P.,
Nivsarkar, M and Anandjiwala, S
(2009) HPTLC densitometric
quantification of Glycyrrhizin, Glycyrrhetinic Acid, Apigenin, Kaempferol and
quercetin from Glycyrrhiza glabra.
Chromatographia 70, 1665-1672.
Impact Factor:
Nivsarkar, M and Banerjee, A
(2009) Establishing the probable mechanism of L-
DOPA in Alzheimer’s disease management.
Acta Polonica 66(5), 483-486.
Banerjee, A., Padh, H. and
Nivsarkar, M. (2009) Role of calcium channel in
blastocyst implantation: A novel contraceptive target
Journal of Basic and Clinical
Physiology and Pharmacology 20 (1) 43-53.
Ojha, A., Shep, D.,
Nivsarkar, M., Patel, S., Jaiswal, V and Padh, H
(2009)
Pharmacokinetic profile of a new formulation of injection diclofenac designed for
intradeltoid use.
Expert Opinion on Pharmacotherapy. 10(4) 517-522.
Impact
Factor:
2.018
Nivsarkar, M., Banerjee, A. and Padh, A
(2008) Cyclooxygenase inhibitors: A novel
direction for Alzheimer’s management.
Pharmacological Reports. 60, 692-698.
Chauhan, B, Patel, M.M., Padh, H. and
Nivsarkar, M. (2008) Combination
Therapeutic Approach for Asthma and Allergic Rhinitis.
Current Clinical
Pharmacology. 3(3), 185-197.
Impact Factor:
2.500
Joshi, A., Pund, S.,
Nivsarkar, M., Vasu, K. and Shishoo, C
(2008) Dissolution test
for site-specific release isoniazid pellets in USP Apparatus 3 (reciprocating cylinder):
European
Journal
Pharmaceutics and Biopharmaceutics 69(2), 769-775.
Impact Factor:
4.304
Rani, S., Singh, G., Banerjee, A.,
Nivsarkar, M and Padh, H.
(2008) Single and
multiple dose toxicokinetics of rofecoxib in Sprague Dawley rats: Implication of drug
accumulation and sex differences.
Advances in Pharmacology and Toxicology 9
Rani, S., Banerjee, A.,
Nivsarkar, M., Singh, G., Patel, M and Padh, H.
(2008) Serial
and Sparse Sampling Approaches in Single and Multiple Dose Toxicokinetic Studies:
A comparison.
International Journal of Pharmacology and Biological Sciences.
Franklin, PX. Yerande, S., Sudarsanam, S., Padh, H.,
Nivsarkar, M. and Vasu, KK
(2008) 2 Amino-5-thazzolyl Motif: A novel scaffold for designing anti-inflammatory
agents of diverse structures.
European Journal of Medicinal Chemistry. 43 (1),
129-134.
Impact Factor:
3.193
Banerjee, A., Vaghasiya, R., Shrivastava, N., Padh, H. and
Nivsarkar, M. (2007)
Endometrial membrane response in
Mus musculus during implantation by
Vitex
negundo Linn.
Animal Reproduction 4, 46-50.
Banerjee, A., Dholakia, D.,
Nivsarkar, M (2007) Alterations in uterine Environment
by Adrenal Feedback Mechanism during Estrous Cycle.
Journal of Biological
Research. 8, 217-222.
Impact Factor:
0.583
Banerjee, A., Vaghasiya, R. and
Nivsarkar, M. (2007) Adrenalectomy
potentiates the
anti-inflammatory activity of a calcium channel blocker.
Journal of Basic and
Clinical Physiology and Pharmacology. 18(4), 299-306.
Shrivastava, N., Kothari, A., Patel, T and
Nivsarkar, M. (2007) Phytochemical
evaluation and radical scavenging activity of three members from family
asteraceae.
Indian Drugs 44(10), 751-756
.
Rathod, R., Prasad, L.P., Rani, S.,
Nivsarkar, M. and Padh, H
(2007) Estimation of
carvedilol in human plasma by using HPLC-fluorescence detector and its application
to pharmacokinetic study.
Journal of Chromatogr B Analytical Technology and
Biomedical Life Sciences. 857(2):219-23.
Impact Factor:
2.971
Vaghasiya, R., Banerjee, A., Shrivastava, N. and
Nivsarkar, M. (2007) Analgesic
and anti-inflammatory activity of hydroalcoholic extract of
Morus alba Linn
. Indian
Drugs 44(5), 364-367.
Chaula Patel, Patel, M., Rani, S.,
Nivsarkar, M. and Padh, H.
(2007) A new high
performance liquid chromatographic method for determination of atomoxetine in
human plasma and its application for pharmacokinetic study.
Journal of
Chromatography B. 850, 356-360.
Impact Factor:
2.971
Banerjee, A., Vaghasiya, R., Shrivastava, N., Padh, H. and
Nivsarkar, M.
(2006)
Anti-hyperlipidemic effect of
Carica papaya L in Sprague-Dawley rats.
Nigerian
Journal of Natural Products and Medicine. 10, 69-72.
Chauhan, B., Rani, S.,
Nivsarkar, M and Padh, H
(2006) A New Liquid-Liquid
Extraction Method for Determination of Montelukast in Small Volume Human Plasma
Samples Using HPLC with Fluorescence Detector.
Indian Journal of
Pharmaceutical Sciences. 68(4) 517-520.
Impact Factor:
0.630
Shrivastava, N., Srivastava, A., Banerjee, A and
Nivsarkar, M (2006) Anti-Ulcer
activity of
Adhatoda vasica Nees.
Journal of Herbal Pharmacotherapy. 6(2) 43-50.
Nivsarkar, M, Banerjee, A., Shah D., Trivedi, J., Patel, M., Bapu Cherian Padh, H.
(2006) Reduction in aluminum induced oxidative stress by meloxicam in rat brain: an
in vivo and
in vitro study.
Iranian Biomedical Journal. 10(3) 151-155.
Nivsarkar, M, Banerjee, A., Shah, D. and Kurani, S.P.
(2006), Wound Healing
Activity of Hemolok (Sepgard) Gel in Sprague Dawley Rats.
Advances in
Pharmacology and Toxicology. 7(1), 21-23.
Banerjee, A., Shrivastava, N., Kothari, A., and
Nivsarkar, M (2005) Wound Healing
Activity Of
Tridax Procumbens.
Advances in Pharmacology and Toxicology. 6(1),
Rani, S., Guttikar, S., Zope, A., Rathod, R.
Nivsarkar, M. and Padh, H.
(2005)
Zafirlukast pharmacokinetics in healthy Indian male subjects: possibility of
interethenic variability.
The Indian Journal of Allergy, Asthma and Immunology.
Banerjee, A., Shrivastava, N., Padh, H and
Nivsarkar, M. (2005) Anti Ulcer Activity
of Methanolic Extract of
Sapindus Mukorossi.
Indian Drugs. 42(6), 380-383.
Rani, S.,
Nivsarkar, M, Rathod, R. Padh, H.
(2005) Comparative bioavailability of
micronised fenofibrate capsule with the newly developed formulation of fenofibrate
(FENO-TG) in healthy human volunteers.
Cardiology Update, (1) 29-32.
Rani, S.,
Nivsarkar, M, Rathod, R., Guttikar, S and Padh, H.
(2005) Bioequivalence
of fenofibrate tablet formulations in healthy Indian male subjects.
Indian Journal of
Pharmaceutical Sciences. 67(3), 297-301.
Impact Factor:
0.630
Nivsarkar, M, Patel, M., Padh, H., Cherian B. and Shrivastava, N.
(2005), Blastocyst
Implantation failure in mice due to “non receptive endometrium”: endometrial
alterations by
Hibiscus rosa sinnensis leaf extract.
Contraception 71(3), 227-230.
Impact Factor:
2.369
Banerjee, A., Shrivastava, N., Kothari, A., Padh H. and
Nivsarkar, M (2005) Anti
Ulcer Activity of Methanolic Extract of
Eclipta Alba. Indian Journal of
Pharmaceutical Sciences. 67(2), 169-172.
Impact Factor:
0.630
Banerjee, A. and
Nivsarkar M (2005) Search for new contraceptive targets. In:
Pharmaceutical Research and Technology, Nov. 25-29, 2005, Mumbai, India.
Padh, H., Rani, S. and
Nivsarkar, M (2005). Pharma Industry – Opportunities Post
2005. Proceedings of Seminar on Chemicals & Pharmaceuticals., Global Investors’
Shubha Rani, Guttikar, S., Rathod, R., Cherian, B.,
Nivsarkar, M and Padh, H.
(2004) Determination of oral meloxicam pharmacokinetic parameters in Asian
Indians: comparison with German population.
Saudi Arabian Journal of
Pharmaceutical Sciences. 12(4) 144-149.
Patel, M., Cherian, B., Padh, H and
Nivsarkar, M (2004) Olanzepine induced
thrombocythemia in Spargue-Daley rats.
Drug Chemical and Toxicology 27(4) 379-
387.
Impact Factor:
3.207
Nivsarkar M, Rathod, P.D., Vasu, K., Zope, A., Sudarsanam, V., Bapu, C. and Padh,
H.
(2004) Altered glucose tolerance by guanidinothiourea compound in Sprague-
Daley rats: possible mechanism(s) for hyperglycemia.
Indian Drugs 41(5) 294-297.
Cherian, B., Rathod, R., Guttikar, S.,
Nivsarkar M., Rani, S. and Padh, H
(2004) A
rapid selective and sensitive method for extraction and analysis of celecoxib in
Human Plasma.
Indian Drugs 41(4) 221-225.
Nivsarkar, M (2003) Modulation of platelet membrane by free radical induced lipid
peroxidation.
Indian Drugs. 40(8), 479-481.
Pillai, A.D., Rathod, P.R., Franklin, P.X., Patel, M.,
Nivsarkar, M, Vasu, K.V., Padh,
H. and Sudarsanam, V.
(2003) Novel designing approach for dual inhibitors as anti-
inflammatory agents: implication of pyridine template.
Biochemical and Biophysical
Research Communications. 301(1), 183-186
. Impact Factor:
2.548
Cherian, B., Sood, P.P. and
Nivsarkar, M (2003) Organelle specific enzyme markers
as indicators of methylmercury neurotoxicity and antidotal efficacy in mice.
Biometals 16, 279-284.
Impact Factor:
3.172
Nivsarkar, M, Shrivastava, N., Patel, M., Padh, H. and Cherian, B.
(2002) Sperm
membrane
modulation
by Sapindus mukorossi during sperm maturation.
Asian
Journal of Andrology. 4(3), 233-235.
Shubha Rani, Guttikar, S., Zope, A., Cherian, B.,
Nivsarkar, M and Padh, H.
(2002)
Pharmacokinetics of olanzepine in Asian Indians and comparison with other
population: possibility of inter ethnic differences.
Indian Drugs 39(11) 583-588.
Nivsarkar, M, Mukherjee, M. Patel, M., Padh, H and Cherian, B
(2002) Launaea
nudicaulis leaf juice exhibits anti-inflammatory action in acute and chronic
inflammation models in rats.
Indian Drugs, 39(5), 290-292.
Nivsarkar M, Sethi, A., Cherian, B., Patel, M. and Padh, H.
(2001) Involvement of
endometrial membrane sulphydryl groups in blastocyst implantation: sulphydryl
groups as a potential target for contraceptive research.
Contraception 64(4) 255-
259.
Impact Factor:
2.369
Nivsarkar M, De, P., Patel, K.B., Katewa, A, Padh, H. and Bapu, C.
(2001) Sub
acute toxicity of meloxicam a selective COX-2 inhibitor in mice.
Advances in
Pharmacology and Toxicology. 2(2), 27-31.
Nivsarkar, M, Cherian, B. and Padh, H.
(2001) Alpha-terthienyl: a plant derived new
generation insecticide.
Current Science 81(6), 667-672.
Impact Factor:
0.567
Bapu, C., De, P., Patel, K.B., Katewa, A.,
Nivsarkar, M and Padh, H.
(2001) Sub-
acute toxicity study of meloxicam a selective COX-2 inhibitor in rats.
Indian Journal
of Toxicology. 8(2), 163-168.
Nivsarkar, M and Padh, H
(2001) Pulse of Indian Pharma Sector: Issues and
opportunities. In: Indian Pharma Industry Issues and Options. PP: 37-54.
Nivsarkar, M, (
2000), Improvement in circulating superoxide dismutase levels: role
of nonsteroidal anti-inflammatory drugs is rheumatoid arthritis.
Biochemical and
Biophysical Research Communications. 270, 714-716.
Impact Factor:
2.548
Nivsarkar, M, (
1999) Identification of alpha-terthienyl radical
in vitro: a new aspect in
alpha-terthienyl phototoxicity.
Current Science, 76(10), 1391-1393.
Impact Factor:
Nivsarkar, M, Cherian, B. and Patel, S.
(1998) A regulatory role of sulphydryl groups
in modulation of sperm membrane conformation by heavy metals: sulphydryl groups
as markers for infertility assessment.
Biochemical and Biophysical Research
Communications. 247, 716-718.
Impact Factor:
2.548
Nivsarkar, M, Patel, R.Y. and Mokal, R.
(1996) Modulation of sperm membrane
confirmation by pentoxifylline in oligopsermia: a biophysical investigation of sperm
membrane
in vitro.
Biochemical and Biophysical Research Communications.
225, 791-795.
Impact Factor:
2.548
Nivsarkar, M, Desai, A. and Mokal, R.
(1996) Free radical induced biophysical
modification of membrane lipids: a novel mechanism proposed for the
haemorheological alteration by 4,5,8’ trimethyl psoralen.
Biochemistry and
Molecular Biology International. 38, 325-333
.
Nivsarkar, M, Kumar, G.P. and Laloraya, M.
(1996) Metal binding and resultant loss
of phototoxicity of alfa-terthienyl: metal detoxification versus alpha-terthienyl
inactivation.
Bulletin of Environmental Contamination and Toxicol. 15, 183-189.
Impact Factor:
0.992
Nivsarkar, M, Kumar, G.P. and Laloraya, M.
(1994) Photophysical alterations of
erythrocyte membrane by 4, 5, 8’ trimethyl psoralen: membrane response towards
Biochemical
and
Biophysical
Research
Communications. 199, 1413-1421.
Impact Factor:
2.548
Nivsarkar, M, Kumar, G.P., Laloraya, M. and Laloraya, M.M.
(1993) Effect of
ultraviolet light activated alpha-terthienyl upon anal gills of mosquito larvae: a spin
label study.
Biochemical Systematics and Ecology. 21, 441-447.
Impact Factor:
Nivsarkar, M, Kumar, G.P., Laloraya, M. and Laloraya, M.M.
(1992) Generation of
superoxide anion radical by alpha-terthienyl in the anal gills of mosquito larvae of
aedes aegypti: a new aspect in alpha-terthienyl phototoxicity.
Archives of Insect
Biochemistry and Physiology. 19, 261-270.
Impact Factor:
1.381
Nivsarkar, M, Kumar, G.P., Laloraya, M. and Laloraya, M.M.
(1991) Superoxide
dismutase inactivation by alpha-terthienyl: a novel observation in thiophene
photochemistry.
Pesticide Biochemistry and Physiology. 41, 53-59.
Impact
Factor:
1.719
Nivsarkar, M, Kumar, G.P., Laloraya, M. and Laloraya, M.M.
(1991) Superoxide
dismutase in the anal gills of mosquito larvae of
Aedes aegypti: its inhibition by
alpha-terthienyl.
Archives of Insect Biochemistry and Physiology. 16(4), 249-255.
Impact Factor:
1.381
Kumar, G.P., Sinha, S., Laloraya, M. and
Nivsarkar, M (1991) Enhanced axial
symmetry at the Fe (II) heme center of peroxidase by ascorbate: the basis for
ascorbate dependent peroxidase action.
Biochemical and Biophysical Research
Communications. 180, 597-601.
Impact Factor:
2.548
Singh, A., Kumar, G.P., Laloraya, M., Verma, S. and
Nivsarkar, M (1991)
Superoxide dismutase activity regulation by spermine: a new dimension in spermine
biochemistry and sperm development.
Biochemical and Biophysical Research
Communications. 177, 420-426.
Impact Factor:
2.548
Verma, S., Kumar, G.P., Laloraya, M.,
Nivsarkar, M and Singh, A.
(1991)
Superoxide dismutase activation in thyroid and suppression in adrenal: novel pituitary
regulatory routes.
FEBS Letters, 282, 310-312.
Impact Factor:
3.541
Kumar, G.P., Seervani, N., Laloraya, M.,
Nivsarkar, M, Verma, S. and Singh, A.
(1990) Superoxide dismutase as a regulatory switch in mammalian testicular
steroidogenesis.
Biochemical and Biophysical Research Communications. 173,
302-308.
Impact Factor:
2.548
Kumar, G.P., Seervani, N., Laloraya, M.,
Nivsarkar, M, Verma, S. and Singh, A.
(1990) Superoxide anion radical induces lipid phase transitions that mimics
temperature induced phase transition phenomenon of membrane lipids.
Biochemical and Biophysical Research Communications. 172, 601-607.
Impact
Factor:
2.548
Verma, S., Kumar, G.P., Laloraya, M., Singh, A.,
Nivsarkar, M and Bharti, S.
(1990)
Discovery of a novel and alternate hydrogen peroxide generation machinery in the
mammalian thyroid gland that modulates iodization of tyrosine.
Biochemical and
Biophysical Research Communications. 169, 1-7.
Impact Factor:
2.548
Laloraya, M., Kumar, G.P.,
Nivsarkar, M and Laloraya, M.M.
(1990) Localization of
superoxide dismutase in the ovary and uterus of mice during pregnancy with special
reference to luteal steroidogenesis and implantation.
Acta Histochemica et
Cytochemica. 23, 271-279.
Impact Factor:
1.600
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Oral gastro retentive fixed dose pharmaceutical compositions for the treatment of
tuberculosis and process for preparation thereof’ Indian Patent Application No: 2829/MUM/2009.
……………………………………………………………………………………………………………
Government:
2007-2010, Awarded by the Department of Biotechnology (DBT), India for “Drug Delivery
and Drug Targeting using therapeutic nano particles”.
2006-2008, Awarded by the Indian Council of Medical Research (ICMR) for “Study on
antioxidative property of
Kalemgh Andrographis paniculata on experimental cataract”.
2004-2007, Awarded by the Department of Biotechnology (DBT), India for “Clinical trials
of a standardized preparation of
Terminalia arjuna in patients with left ventricular
2004-2006, Awarded by the Indian Council of Medical Research (ICMR) for “Chemical
chromatographic evaluation of ayurvedic herbal drugs pre and post shodhana process”.
2004-2005 Awarded by Gujarat Council on Science and Technology (GUJCOST)
Ministry of Science and Technology, Gujarat for “The use of laboratory animals in
toxicokinetic studies using sparse sampling approach”.
2002-2003, Awarded by Gujarat Council on Science and Technology (GUJCOST)
Ministry of Science and Technology, Gujarat for “Reducing the use of laboratory animals
in toxicokinetic studies using sparse sampling: a model dependent approach”.
2002-2004, Awarded by Gujarat Council on Science and Technology (GUJCOST)
Ministry of Science and Technology, Gujarat for “Evaluation of new herbal anti-
inflammatory drugs from family asteraceae”.
2002-2004, Awarded by Gujarat Council on Science and Technology (GUJCOST)
Ministry of Science and Technology, Gujarat for “A new role of anti-inflammatory drugs in
the treatment of neuro-inflammatory diseases”.
2011-2013, Awarded by the Gujarat State Biotechnology Mission (GSBTM), Ministry of
Science and Technology , Gujarat for “A non viral vector for inducing pluripotency”
2011-2013, Awarded by the Department of Biotechnology (DBT): Ministry of Science and
Technology, India for “Pharmacokinetics of
Picrorhiza kurroa”.
2009-2012, Awarded by the Department of Biotechnology (DBT): Ministry of Science and
Technology, India for “Novel Time modulated release drug delivery system of FDC of
Rifampicin and Isoniazid for improved bioavailability and stability”
Industries:
Toxicity studies (> 130) such as Acute, Sub-Acute, Chronic, Sub-Chronic for chemical
and herbal compounds, efficacy studies for herbal formulations, Bioequivalence and
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Invited lectures/conferences/symposia (2010 onwards):
The “6th International Symposium on Innovations in Pharmaceutical Sciences &
Technology” held at Cambay Grand, Ahmedabad in November 2010.
Key roles in the organization of workshops and conducting continuing education
programs for the benefit of doctoral and post doctoral students and staff from industry
Presently teaching faculty for common courses like basis of drug action, spectral
analysis, separation techniques and specialized topics for natural product students and
courses in medicinal chemistry for MS (pharmaceutical science) at NIPER Ahmedabad
As Invited speaker delivered lectures on various topics related to Toxicity, Good
Laboratory Practices, Pharmacology, Documentation, Data generation and experimental
design at various Universities and Organizations.
……………………………………………………………………………………………………………
Member of the editorial board for the International Journal of Pharmacology and
Ethics committee member – Dr. Jivraj Mehta Hospital Ahmedabad.
Visiting faculty at Iladevi Cataract Centre.
Reviewed a number of papers from various national and international journals like
Progress in Neuro-Psychopharmacology & Biological Psychiatry, Life Sciences, Natural
Product Radiance, Indian Journal of Pharmaceutical Sciences and many more.
Have been an external expert to a number of students for their Ph.D. defence and M.
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Source: http://www.niperahm.edu.in/pdf/perd-cv/dr-manish.pdf
Potassium Potassium testing is frequently ordered, along with other , as part of a routine physical. It is used to detect concentrations that are too high ( ). The most common cause of hyperkalemia is , but many drugs can decrease potassium excretion Background: from the body and result in this condition. Hypokalemia can occur if you have diarrhea and vomiting or if you are swea
PROGRAMA DE LA VISITA DE UNA DELEGACIÓN DEL LÍBANO A LA AEAT, Madrid 26, 27 y 28 de julio Martes 26 de julio Hora y lugar: 9:15 h. Paseo de la Castellana 106-108. Salón de Actos de la Delegación Central de Grandes Contribuyentes (DCGC). 9:15 – 9:30 horas: Recepción de los participantes Dña. Amparo Avelló , Jefa de la Unidad de Recursos Humanos de la Delegación Centra