Unit P9, 13/F, Kwun Tong Industrial Centre, Phase 1, 472-484 Kwun Tong Road, Kln. Euromi Peeling with TCA: The Step Peel concept Step Peel is a specific and progressive peel concept. It is recommended that you use European Pharmacopoeia quality trichloroacetic acid in a solution with ultra pure distilled water in a mass and mass concentration in a glass bottle opaque to light. The bottle must have a stopper with dropper tube in order not to contaminate the solution with a cotton stick swab. Recommended concentrations: 18% - 21% - 24% - 27% - 30%. = research for the optimum concentration from week to week. Aqueous solutions of trichloroacetic acid are very acid. The pH of an aqueous solution with a 0.1 molar rate is 1.2. In aesthetic dermatology, the practitioner generally prefers to use solutions with a concentration of 35% and sometimes even higher. The pH of these solutions becomes formidable. This is why it is important to test the cutaneous reaction with solutions of increasing concentration. A reminder of indications: the clinical aspect of skin treated with a solution of trichloroacetic acid depends on the concentration used and on the strength and time of application. In the Step Peel concept, the operator will try not to go past the frosting or perhaps bleaching stage. The practice of chemical peeling shows that the weekly repetition of a peel at low concentration produces a number of impressive long-term aesthetic effects, while assuring the patient comfort, safety and a continuation of social activity. By using various concentrations of trichloroacetic acid, the Step Peel concept is the best way of finding out the patient's sensitivity, tolerance and limit of acceptance of a particular peel. Once these parameters are known, the rule must be "For each patient, his optimum concentration". = the different areas of the face do not react in the same way to the same concentration of trichloroacetic acid. Thanks to the variety of concentrations the practitioner will be able to establish a true mapping of the cutaneous reaction of the face and neck according to the concentration of trichloroacetic acid used. Once this mapping is determined, the rule will be "For each zone, its maximum concentration". This research for the minimum effective concentration is the 1st reason for the The 2nd phase of the Step Peel concept is the cream mask. This should be applied as soon as the frosting or bleaching Target: Protect the skin with 17 components judiciously chosen for total efficacy. Moisturizing, soothing, firming up, lightening, healing, anti-age and antioxidant action. (Muscat rose oil, Ac Kojic, Salix Alba, Methylsilanol Manuronnate, Boswellia Serreta extract, Vitamin K, Ribes Nigrum, Karite butter, Allantoïn, Wheat germ oil, The cream mask is the 2nd reason for the decrease in side effects of TCA. Every product in the GLY KO LINE offers maximum efficacy with minimum irritation in the treatment of the different skin diseases, offering the patient a more reliable and clinically proven solution. The higher the pH, the more the possibility of irritation decreases. Damage caused by U.V. rays appear to be repaired more rapidly when the GLY KO LINE formula is applied daily, 24 hours after exposure to the sun (3-4).All the products of the GLY KO LINE have a concentration between 15 and 20% of the glycolic compound. The choice of a pH of 3.8 for each product assures patients an effective treatment for a healthier skin The GLY KO LINE is a complete system. There are a variety of combinations to respond to any kind of skin disease. The ability of Alpha Hydroxy Acids to reduce hyperkeratosis, to increase hydration and to act as liberating agents represents an important advance in skincare. Most of the major studies concentrate on the most effective of all the AHAs, glycolic acid. It plays a vital role by helping to normalise skin disorders. Compound products of glycolic acid can favourably influence the treatment of a number of skin diseases such as cutaneous ageing, hyperpigmentation, dry skin, greasy skin, acne, lesions The formula chosen is accepted as the most effective. This formula is based on the following principle: the potential irritation of AHAs is much more dependent on pH than on concentration. Since normal skin pH varies from 4.2 to 5.6, the formulas containing free acids (1-2) in which pH is low can be extremely irritating for the skin, even in low concentration. These free acids can even damage the epidermis, due to their corrosive nature. The higher the pH, the lesser the risk of significant irritation. Instead of limiting the concentrations of glycolic acid in the formulas of free acids, we have buffered the acid, which allows higher concentrations of acid, and results in an increase in efficacy without irritation (1-2). Several journals have demonstrated that this formula can help repair damage caused by U.V. rays on the skin and that the process of exfoliation does not appear to compromise or to increase the risk of damage to skin by U.V. rays (3-4). 1. DiNardo JC, Grove GL, Moy LS. 12 % ammonium lactate vs 8 % glycolic acid. J Geriatric Derm. 1995;3:144-147. 2. DiNardo JC, Grove GL, Moy LS. Clinical and histological effects of glycolic acid at different concentrations and pH levels. Derm Surg and Onc. Accepted for publication, May 1995. 3. Elson M. The utilization of glycolic acid in photoaging. Cos Derm. 1992; 5:12-15. 4. Ridge JM, Siegle RJ, Zuckerman J. Use of alpha hydroxy acids in the therapy for photoaged skin. J Amer Acad Derm. 1990. 5. DiNardo JC. A comparison of salicylic acid, salicylic acid with glycolic acid and benzoyl peroxide in the treatment of acne. 6. Murad H, et al. Study shows that acne improves with glycolic acid regimen. Cos Derm. 1992:32-35. 7. Rubin MG, Becker F, Speelman P. Comparative safety and efficacy of glycolic acid peels with various pH levels. If you have any enquiry to Euromi TCA peeling products just contact to our Sales, Ms Viola Tsang / Contact no: 9148 7406 Unit P9, 13/F, Kwun Tong Industrial Centre, Phase 1, 472-484 Kwun Tong Rd, Kln



Field testing of a fish bioconcentration model proposed for risk assessment of human pharmaceutical residues in aquatic environments Jeffrey N. Brown†, Nicklas Paxéus*, Lars Förlin‡ and D.G. Joakim Larsson† † Institute for Neuroscience and Physiology, the Sahlgrenska Academy at Göteborg University, Sweden. * Environmental Chemistry, Gryaa

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