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Microsoft word - 2011 04 26 mgc trg programma v2ves.doc

MGC-AIO course:
Transgenesis, Gene Targeting and in
vivo Imaging
Leiden, LUMC,
A: Basic course
Building 1, lecture hall 2 (K1-S)
May 9-11, 2011
B: International Innovative Mouse Model workshop
Building 3, Buruma hall
May 12-13, 2011
Organizers: Sjef Verbeek, Els Robanus Maandag and Riccardo Fodde Program and Additional Information
Monday, May 9
Lecture hall 2 (K1-S)
N.B. Lunches will be provided throughout the week to all participants free of charge Tea / Coffee will be provided between 3-4 p.m. Afternoon
Lecture hall 2 (K1-S)
Tuesday, May 10
Lecture hall 2 (K1-S)
Parallel sessions in vivo imaging Afternoon
Lecture hall 2 (K1-S)
Wednesday, May 11
Morning:
Lecture hall 2 (K1-S)
Afternoon:
Lecture hall 2 (K1-S)
Discussion forum: Which animal model is the best? 6th Workshop on
Innovative Mouse Models
Leiden University Medical Center, Leiden, the Netherlands
Topics
rAAV directed gene targeting, recombineering, Zinc-finger nuclease assisted gene targeting,
Epigenetic programming in iPS cells, ES cell derivation and culture,
Meganuclases, TALE nucleases,
Invited speakers
Tomas Cermak
Engineered TAL effector nucleases: new tools for genome

Ivo Huijbers

Fast track production of complex tumor models starting
from GEMM-derived embryonic stem cells

Rob Howes

rAAV mediated gene targeting in human and animal cells
Cambridge

Samer Hussein

Genetic mosaicism and selection during reprogramming
to pluripotency

Ralf Kühn Zinc finger nuclease assisted gene targeting
Munchen

Guillermo Montoya

Molecular scissors for in situ cellular repair
Madrid

Jennifer Nichols

Manipulating pathways to improve ES cell culture and
derivation

Francis Stewart

Advanced transgenesis and genome engineering using
recombineering and site-specific recombinases
Suggestions for further reading
Size matters: use of YACs, BACs and PACs in transgenic animals (Review) Patricia Giraldo & Lluís Montoliu; Transgenic Res 10, 83–103, 2001.
Generating transgenic mice from bacterial artificial chromosomes: transgenesis efficiency, integration Margaret L. Van Keuren et al .; Transgenic Res (2009) 18, 769–785
Transposon-mediated genome manipulation in vertebrates (Review) Zoltán Ivics et al.; Nature Meth (2009) 6, 415-422
The impact of site-specific recombinases on genetic analyses in mice (Review) Catherine S. Branda and Susan M. Dymecki; Dev Cell (2004), 6, 7–28,
Engineering chromosomal rearrangements in mice (Review) Yuejin Yu and Allan Bradley; Nat Rev Genet (2001), 2, 780-790
Contemporary approaches for modifying the mouse genome (Review) David J. Adams and Louise van der Weyden; Physiol Genomics (2008), 34, 225-238
The mouse ascending: perspectives for human-disease models (Review) Nadia Rosenthal and Steve Brown; Nat Cell Biol (2007), 9, 993-999
Non-germline genetically engineered mouse models for translational cancer research (Review) Joerg Heyer et al.; Nat Rev Cancer (2010), 10, 470-480
F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate William T Poueymirou, et al ; Nat Biotech (2007), 25, (1), 91-99
A mouse knockout library for secreted and transmembrane proteins Tracy Tang et al., Nat Biotech (2010), 28, 749-755
Toward simpler and faster genome-wide mutagenesis in mice Sen Wu1 et al., Nat Genet (2007), 39, 922-930
Efficient generation of germ line transmitting chimeras from C57BL/6N ES cells by aggregation with Marina Gertsensteinet al.; PLoS ONE (2011), 5 (6), e11260
A practical summary of site-specific recombination, conditional mutagenesis, and tamoxifen induction Anastassiadis K et al.; Methods Enzymol (2010), 477,109-23
Imaging in the era of molecular oncology (Review) Ralph Weissleder & Mikael J. Pittet Nature (2008), 452, 580-589
Nagy, A.; Gersenstein, M.; Vintersten, K.; Behringer R., Cold Spring Harbor Laboratory Press 2002 Practical Approach Oxford University Press 2006 Mammalian and Avian Transgenesis New Approaches WEBSITES OF RESOURCES
A. International Knockout Mouse Consortia
(Cell 2007; 128: 9-13 and Cell (2007), 129: 235) http://www.komp.org/
EUCOMM (Europe): http://www.eucomm.org/
NorCOMM (Canada): http://www.norcomm.org/index.htm
http://www.tigm.org/
Portal: The International Knockout Mouse Consortium (IKMC): http://www.knockoutmouse.org/about
resources
International Mouse Strain Resources (IMSR): global searchable catalog of mouse strain resources http://www.findmice.org/index.jsp
JAX Mice (The Jackson Laboratory): mouse product list, technical support, mice: http://jaxmice.jax.org/index.html
Induced Mutant Resource (IMR): genetically engineered mice, The Jackson Laboratory http://www.jax.org/imr/index.html
Mutant Mouse Regional Resource Centers (MMRRC): mouse strain and ordering information from NCRR's regional mutant mouse repositories: http://www.mmrrc.org/
Mammalian Genetics Unit (MGU): mouse stock list, mouse Embryo Bank, MRC, Harwell (UK) http://www.har.mrc.ac.uk/
European Mouse Mutant Archive (EMMA): repository for transgenic mouse lines (Italy): http://www.emmanet.org/
Oak Ridge National Laboratory (ORNL): mouse mutant stocks, Oak Ridge National Laboratory http://www.nih.gov/science/models/mouse/resources/ornl.html
Neuromice.org: database and repository of mouse neurological mutants: http://www.neuromice.org/
Wellcome Trust Sanger Institute Cambridge UK (MICER) http://www.sanger.ac.uk/resources/mouse/
C. Mouse and expression data bases
Mouse Atlas of Gene Expression (Canada): http://www.mouseatlas.org/data/mouse/project_tissue_view
http://www.brain-map.org/
Gene Expression Database (GXD) (MGI): http://www.informatics.jax.org/expression.shtml
D. Anatomy
The Anatomy of the Laboratory Mouse Margaret J. Cook http://www.informatics.jax.org/cookbook/
E. Cre transgenic mouse strains
The CREATE (Coordination of resources for conditional expression of mutated mouse alleles) project http://www.creline.org.
Cre-X-Mice: a database of Cre transgenic lines http://nagy.mshri.on.ca/cre_new/index.php
F. General
http://www.ensembl.org/Mus_musculus/Info/Index/
The “International Society for Transgenic Technologies (ISTT)” is a non-profitmaking Society http://www.transtechsociety.org/
WHO IS WHO
Faculties
Organizers/ Lecturers
Prof. Riccardo Fodde
Experimental Pathology, Erasmus MC, Rotterdam.
Tel.: 010-4088490
E-mail: r.fodde@erasmusmc.nl
Dr. Els Robanus Maandag
Dept. of Human and Clinical Genetics, LUMC, Leiden
Tel.: 071-5269511
E-mail: e.c.robanus@lumc.nl
Dr. Sjef Verbeek
Dept. of Human and Clinical Genetics, LUMC, Leiden
Tel.: 071-5269410
E-mail: j.s.verbeek@lumc.nl
Lecturers
Cor Breukel
Dept. of Human and Clinical Genetics, LUMC, Leiden
Tel.: 071-5269414
E-mail: c.breukel@lumc.nl
Dr. Lee Fradkin
Dept. of Molecular Cell Biology, LUMC, Leiden
Tel: 071-5269228
E-mail: l.g.fradkin@lumc.nl
Prof. Jeroen den Hertog
Hubrecht Institute, NIOB KNAW, Utrecht
Tel: +31 30 2121800
E-mail: j.denhertog@niob.knaw.nl
Dr. Jos Jonkers
Div. of Molecular Biology, NKI, Amsterdam
Tel.: 020-5122000
E-mail: j.jonkers@nki.nl
Dr. Eric Kaijzel
Dept. of Endocrinology and Metabolic Diseases, LUMC, Leiden
Tel.: 071-5263076
E-mail: e.l.kaijzel@lumc.nl
Dr. Rik Korswagen
Hubrecht Institute, NIOB KNAW, Utrecht
Tel.: 030-2121981
E-mail: rkors@niob.knaw.nl
Dr. Nicolas Legrand
AIMM Therapeutics, Amsterdam
Tel.: 020-5666488
E-mail: nlegrand@aimmtherapeutics.com
Prof. Hein te Riele
Div. of Molecular Biology, NKI, Amsterdam
Tel.: 020-5122084
E-mail: h.t.riele@nki.nl
Dr. Catherine Robin
Dept. of Cell Biology, Erasmus MC, Rotterdam
Tel.: 010-7044795
E-mail: c.robin@erasmusmc.nl
Dr. Daniela Salvatori
Animal Facility (PDC), LUMC, Leiden
Tel.: 071-5269688
E-mail: d.c.f.salvatori@lumc.nl
Dr. Margriet Snoek
Div. of Molecular Genetics, NKI, Amsterdam
Tel.: 020-5122001
E-mail: snoek@nki.nl
Dr. Marcel Veltrop
Dept. of Human and Clinical Genetics, LUMC, Leiden
Tel.: 071-5269427
E-mail: m.h.a.m.veltrop@lumc.nl
Prof. Arn van den Maagdenberg
Dept. of Human and Clinical Genetics, LUMC, Leiden
Tel.: 071-5269460
E-mail: a.m.j.m.van_den_maagdenberg@lumc.nl
Dr. Harald Mikkers
Dept. of Molecular Cell Biology, LUMC, Leiden
Tel: 071-5269668
E-mail: h.mikkers@lumc.nl
Dr. Marc van de Wetering
Hubrecht Institute, NIOB KNAW, Utrecht
Tel.: 030-2121848
E-mail: m.vandewetering@hubrecht.eu
Dr. Joop Wiegant
Dept. of Molecular Cell Biology, LUMC, Leiden
Tel: 071-5269222
E-mail: j.c.a.g.wiegant@lumc.nl

Source: http://www.medgencentre.nl/transgenesis/2011%2004%2026%20MGC%20Trg%20programma%20v2vES.pdf

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