EMEA COMMITTEE FOR VETERINARY MEDICINAL PRODUCTS, PRAZIQUANTEL, A study to evaluate the bioequivalence in horses of ivermectin formulated as an oral paste and ivermectin formulated as an oral Xiao SH et al. (1992) Plasma pharmacokenetics and therapeutic efficacy of praziquantel and 4-hydroxypraziquantel in Schistosoma japonicum-infected rabbits after oral, rectal, and intramuscular administration H. Bj rklund et al. (1987) Absorption, distribution and excretion of the anthelmintic praziquantel ( Droncit ) in rainbow trout K Patzschke et al. (1979) Serum concentrations and renal excretion in humans after oral administration of praziquantel - results of Eur J Drug Metab Pharmacokinet. 1979, No3, 149-156 KU B hring et al. (1978) Metabolism of praziquantel in man Eur J Drug Metab Pharmacokinet. 1978, 179-190 G Leopold et al. (1978) Clinical pharmacology in normal volunteers of praziquantel, a new drug against Schistosomes and Europ J clin Pharmacol. 1978, (14), 281-291 H Jung et al. (1991) Clinical pharmacokinetics of praziquantel Proc West Pharmacol Soc. 1991, (34), 335-340 Praziquantel - Acute toxicity study in rats after oral administration Acute dermal toxicity study in rabbits (limit test) EMBAY 8440 Test of subacute toxicity in rats in oral administration (4-week study) EMBAY 8440 Subacute toxicity test in dogs with oral administration (4-week test) EMBAY 8440 Subchronic toxicity study on dogs with oral administration (13-week trial) M Ketkar et al. (1982) A chronic study of praziquantel in Syrian golden hamsters and Sprague-Dawley rats EMD 29810 Chronic studies with praziquantel in Sprague-Dawley rats EMD 29810 Long-term studies with praziquantel in Syrian golden hamsters EMBAY 8440 Tests for fertility and general reproductive capability in rats after oral administration EMBAY 8440 (EMD 29810 ) Testing for teratogenic effect in rats after oral administration EMBAY 8440 (EMD 29810 ) Test for teratogenic effect in rats after oral administration EMBAY 8440 (EMD 29810 ) Tests for perinatal toxicity in rats - Section 2 - raising and breeding of F1 animals EMD 29810 ( EMBAY 8440 ) Test for teratogenic effects in rabbits after oral administration EMBAY 8440 (EMD 29810 ) Trial for teratogenic effect in Himalayan rabbits after oral administration EMBAY 8440 (EMD 29810 ) Trial for mutagenic potential in bacteria with and without added metabolizing system Investigation of EMBAY 8440 for mutagenic effect in the NMRI mouse. Dominant lethal test in treatment of female animals EMBAY 8440 Micronucleus test in the mouse for mutagenicity testing Mutagenicity studies with praziquantel, a new anthelmintic drug, in mammalian systems Results of Toxicological studies on praziquantel Review of the genotoxicity and carcinogenicity of antischistosomal drugs; is there a case for a study Anwar WA et al. (1993) Reduction in chromosomal damage in schistosomiasis patients after treatment with praziquantel Anwar WA (1993) Praziquantel ( antischistosomal drug): is it clastogenic, co-clastogenic or anticlastogenic? Mutation at the HPRT locus in patients with neurocysticercosis treated with praziquantel Acute dermal irritation study in rabbits Skin sensitization study in guinea pigs using the modified Buehler method Report of the WHO informal consultation on the use of praziquantel during pregnancy/lactation and albendazole/mebendazole in children under 24 months.
Promotion of rat hepatocarcinogenesis by praziquantel Jpn. J. Cancer Res. 1991, (82), 1085-1088

Source: http://www.fsc.go.jp/hyouka/hy/hy-tuuchi-hadaclean170607.pdf

Altitude advice

Information on High Altitude Trekking This document will introduce you to the effects of high altitude trekking and the importance of acclimatization; the process of the body adjusting to the decreased availability of oxygen in high altitudes. All of our guides and staff are trained to identify and treat altitude sickness. However, it is still important to read this packet so you will


FREZ-ART Chi è Massimiliano Frezzato? via Ozanam 7 (int. cortile), Torino 13 - 24 aprile 2012 Inaugurazione venerdì 12 aprile in presenza dell’artista ore 18-21 dal martedì al sabato, 15.30 – 19.15 mostra a cura di Sergio Pignatone La Little Nemo Art Gallery presenta, in esposizione e vendita, tavole originali, illustrazioni e dipinti di Massimiliano Frezzato

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