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Girl power: estrogen promotes hsc self-renewal
Girl Power: Estrogen Promotes HSC Self-Renewal
Esther and Susan 1Immune Receptors of the Innate and Adaptive System Team, Institut d’Investigacions Biome`diques August Pi i Sunyer, Centre EstherKoplovitz, Rossello´, 149À153, 08036 Barcelona, Spain2Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA*Correspondence:
Although some hematopoietic cell types are known to respond to sex hormones, hematopoietic stem cells(HSCs) are generally thought to function similarly in both sexes. Recently in Nature, show that HSCs respond to higher levels of estrogen in females, resulting in enhanced self-renewal andincreased erythropoiesis.
and increase their self-renewing divisions
nificant increase in HSC and MPP cycling.
levels of estrogens in females, particularly
during pregnancy, lead to sex differences
diol. Alternately, increased HSC division
males. HSCs do express low levels of pro-
gesterone receptor (PR), but injection of
in contrast, estradiol stimulates dendritic
cycling is not driven by testosterone in fe-
their progression to erythroid cells. This
) and the more selectively expressed
in erythroid cell precursors by inhibiting
). Nakada et al. show that female
GATA-1; however, it is possible that eryth-
and male HSCs express Esr1
, but not
. ERa is necessary for the estradiol-
more BrdU-labeled HSCs after 10 days.
ERa and use of germline Esr1
correlates with increases in spleen cellu-
specific estriol may promote this process.
HSC cycling to levels seen in males.
estradiol administration. Rigorous pheno-
1 week and yielding serum estradiol levels
recent achievement, and this is the first
subsets. One intriguing possibility is that
Cell Stem Cell 14
, February 6, 2014 ª2014 Elsevier Inc. 137
S.K. was supported by NIH AI92511. E.C. wassupported by a BIOTRACK postdoctoral fellow-
genitors that retain long-term repopulat-
Band, A.M., and Laiho, M. (2011). J. MammaryGland Biol. Neoplasia 16
Challen, G.A., Boles, N.C., Chambers, S.M., andGoodell, M.A. (2010). Cell Stem Cell 6
ability to give rise to long-term self-renew-
ing HSCs upon serial transplantation.
Copley, M.R., Beer, P.A., and Eaves, C.J. (2012).
Cell Stem Cell 10
of TGFb have been implicated in the regu-
strate if estradiol alters this property of
Illing, A., Liu, P., Ostermay, S., Schilling, A., de
HSCs, an earlier report showed that rela-
Haan, G., Krust, A., Amling, M., Chambon, P.,
Schinke, T., and Tuckermann, J.P. (2012). Haema-tologica 97
in estradiol-treated mice is less quiescent
and yields superior immune reconstitution
Kovats, S., Carreras, E., and Agrawal, H. (2010).
Sex steroid receptors in immune cells. In SexHormones and Immunity to Infection, S.L. Klein
and C.W. Roberts, eds. (New York: Springer),
sooner, since their serial transplant even-
Medina, K.L., Garrett, K.P., Thompson, L.F., Rossi,
tually leads to reduced numbers of granu-
M.I., Payne, K.J., and Kincade, P.W. (2001).
allow subsequent MEP differentiation.
Nakada, D., Oguro, H., Levi, B.P., Ryan, N., Kitano,
A., Saitoh, Y., Takeichi, M., Wendt, G.R., and
Morrison, S.J. (2014). Nature 505
Notta, F., Doulatov, S., and Dick, J.E. (2010). Blood
Schuettpelz, L.G., and Link, D.C. (2013). Front
Yamamoto, R., Morita, Y., Ooehara, J., Hamanaka,
S., Onodera, M., Rudolph, K.L., Ema, H., and
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138 Cell Stem Cell 14
, February 6, 2014 ª2014 Elsevier Inc.
Pediatrisk Endokrinologi 2008;22:64-69 Behandling av fedme hos barn og unge Helena M. V. Jørgensen1, Therese Knag2, Yngvild Danielsen3, Pétur B. Júlíusson4,5 1Det medisinsk-odontologiske fakultet, Universitetet i Bergen; 2Avdeling for klinisk ernæring, Haukeland Universitetssykehus; 3Avdeling for samfunnspsykologi, Universitetet i Bergen; 4Barneklinikken, Haukeland Universitetssykeh
Club Information Manual Section 3.7 Dec 2001 ANTI-DOPING POLICY Operational Manual 4.2 What is the Federation ’s Position on Doping?Investigation of a Doping Offence and Referral to HearingHow wil the Federation Enforce Sanctions?Review of a Finding of a Doping Offence or a SanctionIn this Policy: "AIS" means the Australian Institute of Sport. "ADCO" means the An