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Microsoft word - euglumide.doc
Each tablet contains 5mg of glibenclamide.
Such hypoglycemic episodes are nearly always promptly
relieved by the intake of sugar. The occurrence of
hypoglycemic episodes must be immediately reported to
Glibenclamide, the active ingredient of Euglumide tablets, is an oral
hypoglycemic agent belonging to the sulfonylureas. It lowers raised
The treatment of diabetes requires regular checks until
blood sugar and reduces or eliminates sugar excretion in the urine.
optimal control is achieved, or when changing from one
Euglumide 5 mg is used to treat certain forms of diabetes.
product to another, or when tablets not taken regularly.
When situation of unusual stress arise ( e.g. emergency,
surgery, febrile infections ), a temporary change to insulin
Non-insulin-dependent diabetes mellitus ( type II, maturity-onset
diabetes mellitus ) , if the metabolism cannot be satisfactorily
controlled by a suitable diet, exercise or weight reduction alone.
This drug could be useful in certain cases of diabetes
Dosage and Administration:
mellitus, it should not be used except under continuous
Initial stabilization on Euglumide must be undertaken by a
strict medical supervision and should not be dispensed
It is recommended that treatment be started with half a tablet of
Euglumide (2.5 mg ) taken immediately, before breakfast.
If necessary, the dose is increased in increments of 2.5 mg
Drugs which may potentiate the hypoglycemic action of
Euglumide preferably at one week intervals, until the blood sugar is
controlled. As a rule the maximum effect is attained with 3 tablets
Beta-receptor blockers, bezafibrate, biguanides,
per day, in exceptional cases with 4 tablets daily.
chloramphenicol, clofibrate, coumarin derivatives,
The maximum single dose is 2 tablets of Euglumide and should not
fenfluramin, MAO-inhibitors, pentoxifylline (high
be exceeded. It is to be taken before breakfast, if excess is needed, it
dosage, parenteral ), phenylbutazone, phenyramidol,
phosphamides salicylates, sulphinpyrazone,
The dosage scheme can be adjusted according to the dietary habits
sulphonamides and tetracycline compounds.
Drugs which may attenuate the hypoglycemic action of
Abuse of laxatives, corticosteroids, nicotinic acid (high
- Insulin-dependent diabetes mellitus ( type I, juvennile diabetes ).
dosage), estrogens, gestagens, phenothiazine derivatives,
- Diabetic coma, diabetic decompensation ( i.e. keto-acidosis ).
- Severe renal impairment, hypersensitivity to glibenclamide.
In some patients, skin rash or fever may develop. Rarely,
Compliance to diet and regular tablet intake are of utmost
importance to preserve the efficiency of treatment and to avoid
constipation, diarrhea and anorexia may occur.
The simultaneous intake of alcohol might lead to an unwanted
potentiation or attenuation of the hypoglycemic action of
Euglumide. Hypoglycemic reactions may be provoked by
overdosage of glibenclamide and interacting drugs or improper
Hypoglycemic manifestations are: headache, irritability, restlessness,
profuse sweating, insomnia, tremors, impairment of performance
Chemipharm Pharmaceutical Industries
6th October City - Egypt
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