Brcasymposium.ca

BRCA: Twenty Years of Advances
Fifth International Symposium on Hereditary
Breast and Ovarian Cancer
April 23-25, 2014
Centre Mont-Royal, Montréal
Wednesday, April 23, 2014
REGISTRATION & CONTINENTAL BREAKFAST. Foyer 4th Floor Welcome and Introduction to the Programme .Salon Mont-Royal
Harley Eisman, MD, Co-Founder, Hereditary Breast and
Ovarian Cancer Foundation, Montréal, QC, Canada
Words of Introduction:
Montréal, McGill and the BRCA Connection. Salon Mont-Royal
David Eidelman
, Dean, Faculty of Medicine, McGill University, Montréal, QC,
Canada
Overview of Today's Sessions .Salon Mont-Royal
William Foulkes, MBBS, PhD, Director, Program in Cancer Genetics,
McGill University, Montréal, QC, Canada
Session 1: Mutations, variants and databases
CHAIR: Peter Devilee, PhD, Leiden University Medical Centre, Leiden, The Netherlands

08:15 - 09:45

LECTURE . Salon Mont-Royal
The BIC Database: Calm in the center of the storm

Lawrence Brody, PhD, National Human Genome Research Institute,
National Institutes of Health, Bethesda, MD, USA LECTURE . Salon Mont-Royal
Variants of unknown significance: from identification to
validation

Alvaro Monteiro, PhD, H. Lee Moffitt Cancer Center, Tampa, FL, USA
PROFFERED PAPER 1 (S1-PP1) . Salon Mont-Royal
Incidence of BRCA1 and BRCA2 non-founder mutations
in patients of Ashkenazi Jewish ancestry
Eric Rosenthal
, PhD, ScM, Myriad Genetic Laboratories Inc., Salt Lake City, UT,
USA
PROFFERED PAPER 2 (S1-PP2) . Salon Mont-Royal
BRCA1 CIRCOS: A visualization resource for functional
analysis of missense variants
Ankita Jhuraney
, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL,
USA
BRCA: Twenty Years of Advances
Wednesday, April 23, 2014 (cont'd)
PROFFERED PAPER 3 (S1-PP3) . Salon Mont-Royal
CIGMA (Clinical Impact of Genetic Mutation Analysis): A novel
variant classification system for cancer predisposition genes
Clare Turnbull
, MD, PhD, Institute of Cancer Research, London, UK
Question and discussion period (all speakers) . Salon Mont-Royal
Session 2: Molecular pathology: new data and emerging concepts
CHAIR: David Huntsman, MD, PhD, BC Cancer Agency, Vancouver, BC, Canada

10:15 - 11:45

LECTURE . Salon Mont-Royal
Molecular pathology of breast cancer in carriers
of DNA repair gene mutations
Jorge Reis-Filho
, MD, PhD, Memorial Sloan-Kettering Cancer Center,
New York, NY, USA
LECTURE . Salon Mont-Royal
On the origin of high grade serous cancers in BRCA1/2 carriers
Christopher Crum
, MD, Brigham and Women's Hospital, Boston, MA, USA
PROFFERED PAPER 1 (S2-PP1) . Salon Mont-Royal
Identification and validation of an anthracycline /
cyclophosphamide-based chemotherapy response
assay in breast cancer
Jude Mulligan
, Almac Diagnostics, Craigavon, UK
PROFFERED PAPER 2 (S2-PP2) . Salon Mont-Royal
Screening formalin fixed and paraffin-embedded (FFPE)
archival tissue for mutations in BRCA1/2 - a new paradigm
in genetic counseling
Anders Bojesen
, MD, PhD, Vejle Hospital, Vejle, Denmark
PROFFERED PAPER 3 (S2-PP3) . Salon Mont-Royal
TBC

Question and discussion period (all speakers) . Salon Mont-Royal

LUNCH.Foyer 3rd Floor (one level down) BRCA: Twenty Years of Advances
Wednesday, April 23, 2014 (cont'd)
Session 3: Clinically relevant advances in molecular genetics

of BRCA1/2
CHAIR: Jorge Reis-Filho, MD, PhD, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
13:15 - 14:45

LECTURE . Salon Mont-Royal
Next generation sequencing of BRCA1/2 tumors:
what have we learnt?

Andrew P. Futreal, PhD, MD Anderson Cancer Center, Houston, TX, USA
LECTURE . Salon Mont-Royal
Haploinsufficiency for BRCA1
- the key to understanding tissue specificity?
David Livingston
, MD, Dana-Farber Cancer Institute, Boston, MA, USA
PROFFERED PAPER 1 (S3-PP1) . Salon Mont-Royal
A novel BRCA1-mRNA splicing complex is required
for efficient DNA repair and maintenance of genomic stability
Kienan Savage
, Centre for Cancer Research and Cell Biology,
Queen's University Belfast, Belfast, Co. Antrim, UK
PROFFERED PAPER 2 (S3-PP2) . Salon Mont-Royal
BRCA1 haploinsufficiency compromises the repair of stalled
replication forks and increases the risk of genomic instability
Shailja Pathania
, PhD, Dana-Farber Cancer Institute, Boston, MA, USA
PROFFERED PAPER 3 (S3-PP3) . Salon Mont-Royal
Chemotherapy depletes intratumoral PARP1 protein
in ovarian cancer patients
Maud Marques
, PhD, Lady Davis Institute, Montréal, QC, Canada
Question and discussion period (all speakers) . Salon Mont-Royal

Poster Session 1
POSTER SESSION 1 (WITH REFRESHMENTS) . Foyer 4th Floor
Round table: The causes and consequences of the US

Supreme Court ruling on the patenting of genes
ROUND TABLE . Salon Mont-Royal
MODERATOR: Alvaro Monteiro, PhD, H. Lee Moffitt Cancer Center & Research
DISCUSSANTS:
Lawrence Brody
, PhD, National Human Genome Research Institute, Bethesda,
MD, USA; E. Richard Gold, LLM, SJD, McGill University, Montréal, QC, Canada;
Robert Cook-Deegan, MD, Duke University, Raleigh, NC, USA
Question and discussion period (all speakers)
BRCA: Twenty Years of Advances

Thursday, April 24, 2014

CONTINENTAL BREAKFAST. Foyer 4th Floor Introduction to the Day's Proceedings .Salon Mont-Royal
Harley Eisman, MD, Co-Founder, Hereditary Breast and Ovarian Cancer
Foundation, Montréal, QC, Canada
William Foulkes, MBBS, PhD, Director, Program in Cancer Genetics,
McGill University, Montréal, QC, Canada
Session 4: Management of BRCA1/2 mutation carriers: where are
we in 2014?
CHAIR: Steven Narod, MD, FRCPC, Canada Research Chair in Breast Cancer, Women's College
Research Institute/University of Toronto, Toronto, ON, Canada

08:15 - 09:45

LECTURE . Salon Mont-Royal
Management of the woman at risk
Susan Domchek
, MD, University of Pennsylvania, Philadelphia, PA, USA
LECTURE . Salon Mont-Royal
Old and new treatments for hereditary breast
and ovarian cancer

Judy Garber, MD, Dana-Farber Cancer Institute, Boston, MA, USA
PROFFERED PAPER 1 (S4-PP1) . Salon Mont-Royal
The impact of oophorectomy on survival after breast cancer
in BRCA1 and BRCA2 mutation carriers
Kelly Metcalfe
, RN, PhD, University of Toronto, Toronto, ON, Canada
PROFFERED PAPER 2 (S4-PP2) . Salon Mont-Royal
Effect of germ-line BRCA mutations on response to
chemotherapy and outcome of recurrent ovarian cancer
Tamar Safra
, MD, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
PROFFERED PAPER 3 (S4-PP3) . Salon Mont-Royal
MRI volumetric analysis of breast fibroglandular
tissue to assess risk of the spared nipple in BRCA 1
and BRCA2 mutation carriers
John Semple
, MD, FRCSC, BSc(AAM), MSc(Path.), FACS, Women's College
Hospital, Toronto, ON, Canada
Question and discussion period (all speakers) . Salon Mont-Royal
BRCA: Twenty Years of Advances
Thursday, April 24, 2014 (cont'd)
Session 5: Other cancers in carriers: prostate and pancreas
CHAIR: George Zogopoulos, MD, PhD, McGill University, Montréal, QC, Canada
10:15 - 11:45

LECTURE . Salon Mont-Royal
Making an IMPACT on prostate cancer in BRCA1/2 carriers
Rosalind Eeles
, FMedSci, PhD, FRCR, FRCP, Institute of
Cancer Research, London, UK
LECTURE . Salon Mont-Royal
BRCA/PALB2 and other genes that increase the
risk for pancreatic cancer: problems and approaches

Alison Klein, PhD, MHS, Johns Hopkins Medical Institutes, Baltimore, MD, USA
PROFFERED PAPER 1 (S5-PP1) . Salon Mont-Royal
Effect of BRCA mutations on biochemical relapse and
survival after treatment for localized prostate cancer
Rosalind Eeles
, FMedSci, PhD, FRCR, FRCP, Institute of Cancer Research,
London, UK
PROFFERED PAPER 2 (S5-PP2) . Salon Mont-Royal
The impact of a BRCA2 mutation on mortality from
screen-detected prostate cancer
Mohammad R. Akbari
, MD, PhD, Women's College Research Institute/Dalla Lana
School of Public Health, Women's College Hospital/University of Toronto, Toronto,
ON, Canada
PROFFERED PAPER 3 (S5-PP3) . Salon Mont-Royal
Contribution of known and novel BRCA-mediated DNA repair
pathway genes to pancreatic cancer susceptibility
Alyssa Smith
, PhD, Goodman Cancer Research Centre, McGill University,
Montréal, QC, Canada
Question and discussion period (all speakers)….Salon Mont-Royal
LUNCH.Foyer 3rd Floor (one level down) Session 6: Risk communication
CHAIR: Nora Wong, MS, CCGC, Jewish General Hospital, Montréal, QC, Canada

13:15 - 14:45

LECTURE . Salon Mont-Royal
Mates & Dates: Communicating with partners about risk
Karen Hurley
, PhD, Private Practice and Memorial Sloan-Kettering
Cancer Center, New York, NY, USA
LECTURE . Salon Mont-Royal
Mother-child communication of test results:
how to, when to, who to tell

Andrea Farkas Patenaude, PhD, Dana-Farber Cancer Institute, Boston, MA, USA
BRCA: Twenty Years of Advances
Thursday, April 24, 2014 (cont'd)
PROFFERED PAPER 1 (S6-PP1) . Salon Mont-Royal
Access to genetic counseling and BRCA testing among a
population-based sample of young black women
Tuya Pal
, MD, Moffitt Cancer Center, Tampa, FL, USA
PROFFERED PAPER 2 (S6-PP2) . Salon Mont-Royal
Breast cancer risk estimation methods in a clinic-based
cohort of BRCA1/2 mutation carriers
Janet Vos
, University Medical Center Groningen, Groningen, Netherlands
PROFFERED PAPER 3 (S6-PP3) . Salon Mont-Royal
Kintalk.org: Helping families communicate their genetic
information
Megan Myers
, University of California, San Francisco, San Francisco, CA, USA
Question and discussion period (all speakers) . Salon Mont-Royal
Session 7: Special Interest Groups (SIGs) (Participants to choose ONE)
SIG 1 . Salon TBC
How to reduce mortality following breast cancer in BRCA
carriers
Steven Narod
, MD, FRCPC, Canada Research Chair in Breast Cancer, Women's
College Research Institute/University of Toronto, Toronto, ON, Canada

SIG 2 . Salon TBC
Variants of unknown significance workshop

Lawrence Brody, PhD, National Human Genome Research Institute, Bethesda,
MD, USA; Alvaro Monteiro, PhD, H. Lee Moffitt Cancer Center & Research
Institute, Tampa, FL, USA

SIG 3 . Salon TBC
Risk assessment in the clinic: improving on the models
Antonis Antoniou
, PhD, University of Cambridge, Cambridge, UK; Jacques
Simard
, PhD, Laval University, Québec, QC, Canada

SIG 4 . Salon TBC
Beyond BRCA1/2: panels, exomes and genomes
Marc Tischkowitz
, MD, PhD, University of Cambridge, Cambridge, UK;
Peter Devilee, PhD, Leiden University Medical Centre, Leiden, The Netherlands;
Talia Donenberg, MS, CGC, University of Miami, Miami, FL, USA
BRCA: Twenty Years of Advances
Thursday, April 24, 2014 (cont'd)
Session 8: Tubes and tests
TOPIC A . Salon Mont-Royal
Removing the fallopian tubes as way to reduce ovarian cancer
incidence

CHAIR: Marc Tischkowitz, MD, PhD, University of Cambridge, Cambridge, UK
DISCUSSANTS:
Huntsman, MD, PhD, BC Cancer Agency, Vancouver, BC, Canada;
Narod, MD, FRCPC, Canada Research Chair in Breast Cancer, Women's
College Research Institute/University of Toronto, Toronto, ON, Canada TOPIC B . Salon Mont-Royal
Gene panels for breast and ovarian cancer susceptibility
CHAIR: William Foulkes
, MBBS, PhD, McGill University, Montréal, QC, Canada

DISCUSSANTS:

Steven Keiles, MS, CGC, Ambry Genetics, Aliso Viejo, CA, USA;
Brian A. Allen, MS, Myriad Genetic Laboratories, Salt Lake City, UT, USA;
Nazneen Rahman, MD, PhD, Institute of Cancer Research, London, UK
Poster Session 2
POSTER SESSION 2. Foyer 4th Floor
BRCA: Twenty Years of Advances

Friday, April 25, 2014

CONTINENTAL BREAKFAST. Foyer 4th Floor Introduction to the Day's Proceedings
and Housekeeping
.Salon Mont-Royal
Harley Eisman, MD, Co-Founder, Hereditary Breast and Ovarian
Cancer Foundation, Montréal, QC, Canada
William Foulkes, MBBS, PhD, Director, Program in Cancer Genetics,
McGill University, Montréal, QC, Canada
Session 9:
Old genes and new genes for breast and ovarian
cancer

CHAIR: Patricia N. Tonin, PhD, The Research Institute of the McGill University Health Centre,
Montréal, QC, Canada
08:15 - 09:45

LECTURE . Salon Mont-Royal
New genes for breast cancer
Nazneen Rahman, MD, PhD, Institute of Cancer Research, London, UK
LECTURE . Salon Mont-Royal
New genes for ovarian carcinoma
Elizabeth Swisher, MD, University of Washington, Seattle, WA, USA
PROFFERED PAPER 1 (S9-PP1) . Salon Mont-Royal
Bi-allelic BRCA1 mutations identified through whole-exome
sequencing in a patient with intellectual disability, short stature,
microcephaly and early-onset breast cancer
Sarah Sawyer
, PhD, MD, Children's Hospital of Eastern Ontario, Ottawa, ON,
Canada
PROFFERED PAPER 2 (S9-PP2) . Salon Mont-Royal
PALB2 is a high-risk breast cancer susceptibility gene:
A kin-cohort analysis of 154 families
Marc Tischkowitz
, MD, PhD, University of Cambridge, Cambridge, UK
PROFFERED PAPER 3 (S9-PP3) . Salon Mont-Royal
Identification and validation of familial breast cancer
susceptibility genes using targeted sequencing
Ella Thompson
, PhD, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
Question and discussion period (all speakers) . Salon Mont-Royal
Note: Due to unforeseen circumstances, Dr. Charis Eng, Genomic Medicine Institute, Cleveland Clinic, will not be available to present her lecture entitled "PTEN, CDH1, STK11 and TP53: What you need to know in the clinic" which was to have been part of this session. 09:45 - 10:15 BRCA: Twenty Years of Advances
Friday, April 25, 2014 (cont'd)

Session 10: Whole genome approaches to risk
CHAIR: Marc Tischkowitz, MD, PhD, University of Cambridge, Cambridge, UK
LECTURE . Salon Mont-Royal
Identifying modifiers of penetrance of BRCA1/2 mutations

Antonis Antoniou, PhD, University of Cambridge, Cambridge, UK

LECTURE
Whole exome sequencing for breast cancer susceptibility:
the state of play

Devilee,
PhD, Leiden University Medical Centre, Leiden, The Netherlands PROFFERED PAPER 1 (S10-PP1) . Salon Mont-Royal
Clinical impact of a multiple gene sequencing panel for
hereditary breast cancer families
James Ford
, MD, Stanford University School of Medicine, Stanford, CA, USA
PROFFERED PAPER 2 (S10-PP2) . Salon Mont-Royal
Identifying the missing genetic risk in ovarian cancer
Ian Campbell
, PhD, Peter MacCallum Cancer Centre, East Melbourne, VIC,
Australia
PROFFERED PAPER 3 (S10-PP3) . Salon Mont-Royal
Common genomic variants and the risk of breast cancer in
BRCA1 and BRCA2 mutation carriers: evidence for a broad
modifying effect
Paul James
, MBChB, DPhil, FRCAP, Familial Cancer Centre, Peter MacCallum
Cancer Centre, Melbourne, VIC, Australia
Question and discussion period (all speakers) . Salon Mont-Royal
Closing Session: The Marla Miller Memorial Lecture
Introductory Remarks . Salon Mont-Royal
William Foulkes
, MBBS, PhD, Director, McGill University Program in Cancer
Genetics, Montréal, QC, Canada

LECTURE
Breast cancer susceptibility: the knowledge gained
and the challenges that remain
Douglas Easton
, PhD, University of Cambridge, Cambridge, UK
Presentation by the Miller Family .Salon Mont-Royal
Closing Remarks . Salon Mont-Royal
Harley Eisman
, MD, Co-Founder, Hereditary Breast and Ovarian Cancer
Foundation, Montréal, Québec, Canada

Source: http://www.brcasymposium.ca/pdfs/Symposium%20Agenda_BRCA2014.pdf

N oral communications

1- ORAL PRESENTATIONS I : LOWER LIMB 01 Recurring synovitis as a possible reason for aseptic loosening of knee endoprostheses in patients with rheumatoid arthritis B.FINK(1*), I.BERGER(2*), C.SIEGMÜLLER(1*), W.RÜTHER(1*) (1* HAMBURG, GERMANY) (2* MAINZ, GERMANY) Periprosthetic mineralisation around cemented titanium total hip stems M.LENGSFELD, D.GÜNTHER, T.PRESSEL, R.LEPPEK,

Modifying clopidogrel maintenance doses according to vasodilatorstimulated phosphoprotein phosphorylation index improves clinical outcome in patients with clopidogrel resistance

Address for correspondence: Yan Lai, MM Clinical Investigation Department of CardiologyShanghai East HospitalTongji University School of MedicinePhosphoprotein Phosphorylation IndexImproves Clinical Outcome in PatientsWith Clopidogrel ResistanceXiao-dong Wang, MD; Dai-fu Zhang, MM; Shao-wei Zhuang, MD; Yan Lai, MMDepartment of Cardiology, Shanghai East Hospital, Tongji University School

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