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Cooperative Group Patient Representatives See Efforts Pay Off for Multiple Myeloma
Advocates have been working in the Cooperative Groups for more than 10 years. The primary activity
of these advocates is providing the patient perspective to the multi-centered research being designed
and conducted by these organizations. The Eastern Cooperative Oncology Group (ECOG) Patient
Representative Committee recently experienced a surprising and exciting outcome for their efforts.
More than three years ago they engaged multiple myeloma patients in a discussion about upcoming research with the leadership of the ECOG Multiple Myeloma Committee. The patients asked for the
addition of a low dose dexamethesone (Decodron®) arm to a trial the committee was planning using a
regimen of dexamethasone and lenalidomide (Revlimid®) for newly diagnosed patients. The
Committee listened to these patient concerns and E4A03 was designed with two treatment arms. In
arm one, patients received lenalidomide and dexamethasone at standard doses and arm two received
standard-dose lenalidomide and low-dose dexamethasone. The primary objective was to determine if the low-dose arm would have similar response rates and lower toxicity than the standard-dose arm.
Preliminary results have shown that use of low doses of dexamethasone, in combination with
lenalidomide is associated with improved survival when compared to a treatment regimen with
lenalidomide and a higher dose of dexamethasone. According to the National Cancer Institute press
release on the results of this trial, "Researchers found that patients in the study who received low-dose
dexamethasone and lenalidomide had a one-year survival of 96 percent compared to 86 percent for patients treated with the standard-dose of dexamethasone and lenalidomide. In addition, there were
fewer side effects associated with the low-dose dexamethasone and lenalidomide." The trial was
closed early by the data monitoring committee overseeing the trial because of the differences observed
According to Mike Katz, co-chair of the Patient Representative Committee and a member of the ECOG
Multiple Myeloma Committee, "It's rare to get this sort of opportunity/result as an advocate. We think
the impact on clinical practice could be huge since dexamethasone is currently included in so many
Research Advocacy Network 1 of 3 Network News, Volume 5, Issue 4
regimens at the higher dose. Hopefully, these results will provide impetus for other trials incorporating
dose questions." E4A03 was presented at the American Society of Clinical Oncology annual meeting held in Chicago, Ill.,
from June 1 to 5, 2007. To read the National Cancer Institute press release go to
Federal Health Leaders Unveil New Programs to Help Eliminate Disparities in Clinical Trials
On May 7, 2007, Baylor College of Medicine and the Intercultural Cancer Council (ICC), and officials
from the U.S. Department of Health and Human Services' Office of Minority Health and Office on
Women's Health and the National Institutes of Health's National Center on Minority Health and Health
Disparities held a news conference to announce two complementary projects -- CLAS-ACT (Culturally
and Linguistically Appropriate Standards And Clinical Trials) and BackPack (a set of tools for researchers) -- that are among the first to apply new ways to reduce the cultural and linguistic barriers
keeping many underserved patients from participating in clinical trials. This outgrowth of the
Eliminating Disparities in Clinical Trials (EDICT) project will provide new resources, examples and
models for those who design clinical trials and for those who work with minority and underserved
patients at the community level. News conference participants included George A. Strait Jr.,
communications director for the National Center on Minority Health and Health Disparities; Garth Graham, deputy assistant secretary for minority health for the U.S. Department of Health and Human
Services; and Wanda Kaye Jones, Deputy Assistant Secretary for Women's Health for the U.S.
Department of Health and Human Services.
A special edition of Network News to report on highlights from the ASCO
Annual Meeting and the Focus on Research participants and Research
Research Advocacy Network Publications
Tissue Donation for Research Education Booklets
Research Advocacy Network has developed booklets for prospective donors and institutional review
boards to understand the importance and implications of donating tissue for research purposes. These
booklets have been in high demand!!! Thanks to an unrestricted grant from Eli Lilly and Company our stock has been replenished and these are available to be shipped again. Please click here to access
. Genomics in Cancer: An Advocate's Guide
The Research Advocacy Network has introduced an education module for advocates interested in learning more about genetics and genomics and the role of this emerging field in cancer research. The
module covers the science behind genomics, including scientific concepts and examples of how
genomic technology is currently being incorporated into clinical research. To help bring this information
to life, the module also includes basic definitions, diagrams, and graphics - all in an effort to de-mystify
the science and technology. Genomics in Cancer: An Advocate's Guide was supported by an
educational grant and in-kind contributions from Genomic Health, Inc. Order your copy by completing
Research Advocacy Network 2 of 3 Network News, Volume 5, Issue 4
Research Advocacy Network Activities
Events of Interest to Research Advocates
May, June 2007
May 7-8, 2007 EDICT (Eliminating Disparities in Clinical Trials) Opportunity Team Leader
May 9-11 2007 Advocate Institute webinars on Understanding Clinical Trial Design for
Focus on Research and Indiana University Research Advocate Mentor Program
May 12, 2007 Hoosier Oncology Group Annual Meeting, Indianapolis, IN
May 15-17, 2007 Indiana University Breast Cancer Center of Excellence Research Advocate
Mentor Program Intensive, Indianapolis, IN June 1- 5, 2007 American Society of Clinical Oncology Annual Meeting, Chic
June 8- 10, 2007 Eastern Cooperative Oncology Group Spring Meeting, Washington, DC
June 11-13, 2007 NCCTG Patient Advocate Symposium, Rochester, MN
June 22-24, 2007 Radiation Therapy Oncology Group Spring Meeting, Philadelphia, PA
June 24-26, 2007 NCCN Breast Cancer Treatment Guidelines Committee, Virginia
**Some calendar items listed are by invitation only and listed only for your awareness. If you need
information about events listed here without a link to the sponsoring organization, please email
We need your help! Your Donation Makes a Difference! If you believe in the hope of research and the power of advocacy, you can help the Research Advocacy Network (RAN) by sending a donation. RAN is
an exempt 501 c 3 organization and dependent on your support to keep going.
PLEASE NOTE our new mailing address is: 6505 W. Park Blvd, Suite 305, PMB 220, Plano, TX 75093.
Research Advocacy Network Welcomes New Members!!!
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click on "Join." There are no dues for Network membership and this will assure that you receive all
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for funding support for Network News for 2007 through an unrestricted educational grant.
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Research Advocacy Network 3 of 3 Network News, Volume 5, Issue 4
http://learnenglish.britishcouncil.org/en/magazine/food Introduction This support pack accompanies the video magazine article: Food . To read or listen to the article online, go to: This support pack contains the following materials: • a pre-watching vocabulary activity; • the article; • a comprehension task Before you read / listen Match the words and phrases in th
蘇世斌 近 5 年著作 著 （ 2006-2012 ）： SCI 論文 論 ： (* Corresponding author) Shih-Bin Su , Jiang-Nan Wang, Chih-Wei Lu, How-Ran Guo. Reducing urinary tract infections among female clean room workers through health education and behavior modification. Journal of Women’s Health 2006, 15(7): 872-878 (SSCI2010-IF1.454; rank4/35 Women’s study) Shih-Bin Su , Kue