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If you’ve been on an antidepressant for at least 6 weeks and still feel depressed, adding ABILIFY (aripiprazole) to your current treatment could be right for you. To find out, review the questions below and discuss them with your doctor.
How might ABILIFY help treat my unresolved symptoms of depression?
Does adding ABILIFY mean I have to change my current treatment?
How is ABILIFY thought to work?
What side effects should I know about?
How soon might I start to see improvement in my symptoms?
Based on my overall health and current treatment, could ABILIFY be right for me?
ABILIFY is prescribed as an add-on treatment for adults with depression when an antidepressant alone is not enough.ImpOrTANT SAfeTy INfOrmATION:
elderly people with psychosis related to dementia (for example, an inability to perform daily activities as a result of increased memory loss),
treated with antipsychotic medicines including ABILIfy, are at an increased risk of death compared to placebo. ABILIfy is not approved for
the treatment of people with dementia-related psychosis (see Boxed WArNING).
Antidepressants may increase suicidal thoughts or behaviors in some children, teenagers, and young adults, especially within the first
few months of treatment or when the dose is changed. Depression and other serious mental illnesses are themselves associated with an
increase in the risk of suicide. patients on antidepressants and their families or caregivers should watch for new or worsening depression
symptoms, unusual changes in behavior, or thoughts of suicide. Such symptoms should be reported to the patient’s healthcare provider right
away, especially if they are severe or occur suddenly. ABILIfy is not approved for use in pediatric patients with depression
(see Boxed WArNING).
Please see continued IMPORTANT SAFETY INFORMAincluding Boxed WARNINGS
ImpOrTANT SAfeTy INfOrmATION (continued) for ABILIfy® (aripiprazole)
: Patients should not use ABILIFY if they are allergic to aripiprazole or any of the ingredients in ABILIFY. Allergic reactions have
ranged from rash, hives and itching to anaphylaxis, which may include difficulty breathing, tightness in the chest, and swelling of the mouth, face,
lips, or tongue.Serious side effects may include
■ An increased risk of stroke
and ministroke have been reported in clinical studies of elderly people with dementia-related psychosis
■ High fever, stiff muscles, confusion, sweating, changes in pulse, heart rate and blood pressure may be signs of a condition called neuroleptic
malignant syndrome (NmS)
, a rare and serious condition that can lead to death
■ Increases in blood sugar levels (hyperglycemia)
can happen in some people who take ABILIFY. Extremely high blood sugar can lead to coma
or death. If you have diabetes
, or risk factors (for example, obesity, family history of diabetes), or have the following symptoms: increases in
thirst, urination, or hunger, feel weak or tired, sick to your stomach, or confused (or breath smells fruity), your blood sugar should be monitored
■ Changes in cholesterol
and triglyceride (fat, also called lipids)
levels in the blood have been seen in patients taking medicines like ABILIFY
■ Weight gain
has been reported in patients taking medicines like ABILIFY so your weight should be checked regularly
■ ABILIFY and medicines like it have been associated with difficulty swallowing
which may lead to aspiration or choking
■ Uncontrollable movements of face, tongue, or other parts of body, as these may be signs of a serious condition called tardive dyskinesia (TD)
TD may not go away, even if you stop taking ABILIFY. TD may also start after you stop taking ABILIFY
■ Orthostatic hypotension (decreased blood pressure)
or lightheadedness or fainting when rising too quickly from a sitting or lying position has
■ Decreases in white blood cells (WBC; infection fighting cells) have been reported in some patients taking ABILIFY. Patients with a history of a
significant decrease in WBC count or who have experienced a low WBC count due to drug therapy should have their blood tested and monitored during the first few months of therapy
■ Seizures (convulsions)
have been reported with ABILIFY. Tell your healthcare provider if you have a history of or are at risk for seizures
■ ABILIFY and medicines like it can affect your judgment, thinking, or motor skills. You should not drive or operate hazardous machinery until you
■ Medicines like ABILIFY can impact your body’s ability to reduce body temperature; you should avoid overheating and dehydration
■ Tell your healthcare provider if you are pregnant or intend to become pregnant. Also tell your healthcare provider about any other medical
conditions you have and about all prescription and non-prescription medicines you are taking or plan to take since there are some risks for drug interactions
Most common side effects (≥10%) from all clinical trials involving adults:
■ Nausea, vomiting, constipation, headache, dizziness, an inner sense of restlessness or need to move (akathisia), anxiety, insomnia,
It is important to contact your healthcare provider if you experience prolonged, abnormal muscle spasms or contractions, which may be signs of a
condition called dystonia.
For patients who must limit their sugar intake, ABILIFY Oral Solution contains sugar.
For patients with phenylketonuria or PKU, ABILIFY DISCMELT® (aripiprazole) contains phenylalanine.If you have any questions about your health or medicines, talk to your healthcare provider.
including Boxed WArNINGS
Tablets manufactured by Otsuka Pharmaceutical Co., Ltd., Tokyo 101-8535, Japan or Bristol-Myers Squibb Company, Princeton, NJ 08543 USA. Distributed and marketed by Otsuka America Pharmaceutical, Inc., Rockville, MD 20850 USA.
2013 Otsuka America Pharmaceutical, Inc., Rockville, MD September 2013 03US13EC0077
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